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Transboundary and Emerging Diseases, Volume 2026, Issue 1, 2026.Toxoplasmosis is a globally significant infectious disease, affecting approximately one‐third of the world’s population. Ocular toxoplasmosis (OT) is a major and vision‐threatening clinical manifestation. However, its pathogenesis remains elusive, and effective targeted therapies are unavailable. This study demonstrates that Toxoplasma gondii infection
Lingling Song +10 more
wiley +1 more source
Transboundary and Emerging Diseases, Volume 2026, Issue 1, 2026.Toxoplasma gondii (T. gondii) is a protozoan parasite that lives inside cells and causes zoonotic diseases in the vast majority of homeothermic vertebrates, such as humans. Despite the critical biological roles of TgGRA47 and TgGRA72 in the determination of T.
Zihan Zhou +5 more
wiley +1 more source
The
mBio, 2016 Ingestion of the obligate intracellular protozoan parasite Toxoplasma gondii causes an acute infection that leads to chronic infection of the host. To facilitate the acute phase of the infection, T.
Barbara A. Fox +6 more
doaj +1 more source
Memorias do Instituto Oswaldo Cruz, 2000 The PyAG1 gene, identified by the screening of a Plasmodium yoelii genomic DNA library with a rhoptry-specific Mab, encodes a protein with a zinc finger structure immediately followed by the consensus sequence of the Arf GAP catalytic site.
Rémi Hienne +3 more
doaj +1 more source
Key Regulators of Parasite Biology Viewed Through a Post‐Translational Modification Repertoire
PROTEOMICS, Volume 25, Issue 21-22, Page 253-276, November 2025.ABSTRACT Parasites are the leading causes of morbidity and mortality in both humans and animals, imposing substantial socioeconomic burdens worldwide. Controlling parasitic diseases has become one of the key issues in achieving “One Health”. Most parasites have sophisticated life cycles exhibiting progressive developmental stages, morphologies, and ...
Naiwen Zhang, Ning Jiang, Qijun Chen
wiley +1 more source
International Journal for ParasitologyProteins released by the club-shaped, apically located, specialized secretory organelles called rhoptries play an essential role in host cell invasion and intracellular survival of apicomplexans. Sarcocystis neurona, the apicomplexan responsible for equine protozoal myeloencephalitis (EPM), lacks rhoptries in its asexual developmental stages, viz ...
Annapoorani, Jegatheesan +5 more
openaire +2 more sources
, 2020 The malaria parasite Plasmodium falciparum invades, replicates within and destroys red blood cells in an asexual blood stage life cycle that is responsible for clinical disease and crucial for parasite propagation.
Ellen Knuepfer (122373) +6 more
core
, 1990 Rhoptry proteins of Plasmodium falciparum merozoites, of 140, 130, and 110 kDa, identified by co-precipitation with Mab.1B9, bind selectively to mouse erythrocytes and reticulocytes.
Perkins, Margaret E. +1 more
core +1 more source
Structuraland antigenic analysis of a new Rhoptry Pseudokinase Gene (ROP54) in Toxoplasma gondii
, 2017 is defined as an obligate intracellular apicomplexan parasite and influences approximatelyone-third of the human all over the world.
Aihua H. Zhou +10 more
core +1 more source
Acidic compartments and rhoptry formation in Toxoplasma gondii
Parasitology, 1998 DAMP (3-(2,4-dinitroanilino)-3′amino-N-methyldipropylamine), which differentially accumulates in acidic compartments, was used to identify such compartments in Toxoplasma gondii tachyzoites at the electron microscope level. In both free tachyzoites and dividing intracellular parasites the only sites of DAMP accumulation were mature and forming ...
M K, Shaw, D S, Roos, L G, Tilney
openaire +2 more sources