Results 71 to 80 of about 5,406 (212)

Erythrocyte Membrane Protein 3 (EMAP3) Is Exposed on the Surface of the Plasmodium berghei Infected Red Blood Cell

open access: yesMolecular Microbiology, Volume 125, Issue 3, Page 233-249, March 2026.
Erythrocyte membrane protein 3 (EMAP3) is a novel Plasmodium berghei protein that is trafficked to the outer membrane surface of the infected red blood cell (iRBC). EMAP3 is not critical for parasite growth or sequestration but offers a new scaffold for displaying Plasmodium falciparum proteins on iRBCs.
Sophia Raine C. Hernandez   +13 more
wiley   +1 more source

Clathrins Are Involved in the Endocytosis of Host Cytosol in the Malaria Parasite

open access: yesTraffic, Volume 27, Issue 1, March 2026.
This study characterized clathrin function in hemoglobin uptake from host red blood cells via the malaria parasite's specific endocytosis machinery, cytostome. Clathrin heavy chain, clathrin light chain, and AP‐1 γ subunit were found associated with certain proteins known to be involved in cytostome function, and they were localized at the collars of ...
Jun Miao   +10 more
wiley   +1 more source

Targeting Aurora Kinases as Essential Cell‐Cycle Regulators to Deliver Multi‐Stage Antimalarials Against Plasmodium Falciparum

open access: yesAngewandte Chemie, Volume 137, Issue 51, December 15, 2025.
In this study, we repurposed human Aurora kinase‐specific inhibitors to identify potential antimalarial agents. Two inhibitors, hesperadin and TAE684, exhibited sub‐micromolar activity across multiple parasite stages, with hesperadin demonstrating significant potency and selectivity by specifically targeting PfArk1.
Henrico Langeveld   +23 more
wiley   +2 more sources

Molecular and Structural Characterization of Foam Proteins from Mahanarva spectabilis (Distant, 1909) (Hemiptera: Cercopidae) Nymphs Reveals Adaptive Features and Potential Targets for Pest Control

open access: yesArchives of Insect Biochemistry and Physiology, Volume 121, Issue 2, February 2026.
Nymphs of Mahanarva spectabilis produce a protective foam that supports survival, reduces plant damage, and contributes to adult population establishment. Proteomic profiling combined with protein sequencing and structural modeling revealed foam proteins enriched in functional domains associated with environmental resilience.
Angelo José Rinaldi   +9 more
wiley   +1 more source

Model of TgDHHC7 and TgARO function in rhoptry biogenesis.

open access: yes, 2013
TgDHHC7 is positioned in the rhoptry membrane with the catalytic DHHC-CRD domain in the cytosol where it recruits TgARO to the cytosolic face of the rhoptries by palmitoylation.
Peter J. Bradley (225949)   +6 more
core   +1 more source

Identification of a new rhoptry neck complex RON9/RON10 in the Apicomplexa parasite Toxoplasma gondii. [PDF]

open access: yesPLoS ONE, 2012
Apicomplexan parasites secrete and inject into the host cell the content of specialized secretory organelles called rhoptries, which take part into critical processes such as host cell invasion and modulation of the host cell immune response.
Mauld H Lamarque   +7 more
doaj   +1 more source

Optimisation of freeze substitution protocols for the examination of malaria parasite structure by volumetric electron microscopy

open access: yesJournal of Microscopy, Volume 301, Issue 2, Page 168-186, February 2026.
Abstract Malaria is one of the deadliest infectious diseases in the world, annually responsible for over 400,000 deaths. It is caused by parasites of the genus Plasmodium, which undergo remarkable structural changes during their development within different cells across various hosts.
Rachel Rachid   +3 more
wiley   +1 more source

Cellular Hallmarks From Volume Electron Microscopy Reveal Developmental Progression of Plasmodium Ookinetes

open access: yesAdvanced Science, Volume 13, Issue 4, 19 January 2026.
This article presents a detailed ultrastructural cell atlas of Plasmodium ookinete development using advanced volume electron microscopy (v) techniques. It defines seven distinct developmental stages, revealing complex organelle interactions and offering new insights into parasite differentiation.
Nedal Darif   +12 more
wiley   +1 more source

A Glycosylphosphatidylinositol-Anchored Carbonic Anhydrase-Related Protein of Toxoplasma gondii Is Important for Rhoptry Biogenesis and Virulence

open access: yesmSphere, 2017
Carbonic anhydrase-related proteins (CARPs) have previously been described as catalytically inactive proteins closely related to α-carbonic anhydrases (α-CAs).
Nathan M. Chasen   +6 more
doaj   +1 more source

Molecular Characterization and Immunological Evaluation of Truncated Babesia microti Rhoptry Neck Protein 2 as a Vaccine Candidate

open access: yesFrontiers in Immunology, 2021
Babesia microti is a protozoan that infects red blood cells. Babesiosis is becoming a new global threat impacting human health. Rhoptry neck proteins (RONs) are proteins located at the neck of the rhoptry and studies indicate that these proteins play an ...
Yu chun Cai   +31 more
doaj   +1 more source

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