Results 51 to 60 of about 5,406 (212)

ThePlasmodiumrhoptry associated protein complex is important for parasitophorous vacuole membrane structure and intraerythrocytic parasite growth [PDF]

, 2017
Plasmodium parasites must invade erythrocytes in order to cause the disease malaria. The invasion process involves the coordinated secretion of parasite proteins from apical organelles that include the rhoptries.
Kit Kennedy, Matthews, K, Paul Sanders, Tania F. de Koning-Ward, Sreejoyee Ghosh, de Koning-Ward, TF, Stuart A. Ralph, Kennedy, K, Counihan, NA, Ghosh, S, Kathryn Matthews, Sanders, P, Natalie A. Counihan, Ralph, SA   +13 more
core   +1 more source

Data_Sheet_1_Functional Characterization of the Thrombospondin-Related Paralogous Proteins Rhoptry Discharge Factors 1 and 2 Unveils Phenotypic Plasticity in Toxoplasma gondii Rhoptry Exocytosis.zip

, 2022
To gain access to the intracellular cytoplasmic niche essential for their growth and replication, apicomplexan parasites such as Toxoplasma gondii rely on the timely secretion of two types of apical organelles named micronemes and rhoptries.
Mario Falchi (120130), Furio Spano (12842189), Lucia Bertuccini (182719), Manlio Di Cristina (814508), Matteo Lunghi (814511), Lorenzo Tramontana (12842186), Chiara Nicastro (12842183), Simona Cherchi (6081008), Alessia Possenti (3335781), Federica Piro (5680772), Valeria Messina (318557)   +10 more
core   +1 more source

Recombinant expression of the rhoptry protein Clag3.1 as a green fluorescent chimeric protein in Plasmodium falciparum [PDF]

Delta Journal of Science, 2013
Like all members of Apicomplexa, the motile form of Plasmodium, the merozoite, possesses anelaborate apical complex composed of 3 organelles; micronemes, rhoptries and dense granules.Invasion of erythrocytes by Plasmodium merozoites is a tightly ...
Ahmed M. Ghoneim
doaj   +1 more source

Members of the Low‐Molecular‐Mass Rhoptry Protein Complex of Plasmodium falciparum Bind to the Surface of Normal Erythrocytes

, 2007
International audienceThe destruction of erythrocytes is one of the most frequently observed causes of severe malarial anemia. Recently, we showed that tagging normal erythrocytes and cells of erythroid precursors with rhoptry-derived proteins can ...
Lepolard, C., Sterkers, Y., Scheidig, C., Scherf, Artur, da Rocha, M., Gysin, J.   +5 more
core   +1 more source

Proteome analysis of rhoptry-enriched fractions isolated from Plasmodium merozoites.

, 2004
The rhoptries of Plasmodium species participate in merozoite invasion and modification of the host erythrocyte. However, only a few rhoptry proteins have been identified using conventional gene identification protocols.
Yates, John R., Wang, Tongmin, Carucci, Daniel J., Raine, J. Dale, Sinden, Robert, Sam-Yellowe, Tobili Y., Florens, Laurence   +6 more
core   +1 more source

The C-terminus of Toxoplasma RON2 provides the crucial link between AMA1 and the host-associated invasion complex. [PDF]

PLoS Pathogens, 2011
Host cell invasion by apicomplexan parasites requires formation of the moving junction (MJ), a ring-like apposition between the parasite and host plasma membranes that the parasite migrates through during entry.
Jessica S Tyler, John C Boothroyd
doaj   +1 more source

Identification of novel rhoptry proteins in Neospora caninum by LC/MS-MS analysis of subcellular fractions

, 2011
Apicomplexan parasites possess an apical complex that is composed of two secretory organelles recognized as micronemes and rhoptries. Rhoptry contents are secreted into the parasitophorous vacuole during the host cell invasion process.
G. Álvarez-García, Alvarez-Garcia, G., A. Hemphill, Hemphill, A., Marugan-Hernandez, V., L.M. Ortega-Mora, Tomley, F., J. Regidor-Cerrillo, F. Tomley, Regidor-Cerrillo, J., V. Marugán-Hernández, Ortega-Mora, L.M.   +11 more
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Toxoplasma gondii rhoptry discharge factor 3 is essential for invasion and microtubule-associated vesicle biogenesis.

PLoS Biology
Rhoptries are specialized secretory organelles conserved across the Apicomplexa phylum, essential for host cell invasion and critical for subverting of host cellular and immune functions.
Rouaa Ben Chaabene, Matthew Martinez, Alessandro Bonavoglia, Bohumil Maco, Yi-Wei Chang, Gaëlle Lentini, Dominique Soldati-Favre   +6 more
doaj   +1 more source

Functional Analysis of the Rhoptry Kinome during Chronic Toxoplasma gondii Infection

mBio, 2016
Toxoplasma gondii is one of the most common parasitic infections of humans worldwide. Once exposed, humans remain infected with T. gondii for life, and there are no therapeutics capable of eliminating a chronic infection.
Laura J. Knoll
doaj   +1 more source

4-Bromophenacyl bromide specifically inhibits rhoptry secretion during Toxoplasma invasion. [PDF]

PLoS ONE, 2009
Toxoplasma gondii is a eukaryotic parasite of the phylum Apicomplexa that is able to infect a wide variety of host cells. During its active invasion process it secretes proteins from discrete secretory organelles: the micronemes, rhoptries and dense ...
Sandeep Ravindran, Melissa B Lodoen, Steven H L Verhelst, Matthew Bogyo, John C Boothroyd   +4 more
doaj   +1 more source