Results 61 to 70 of about 5,406 (212)
A Genetically Encoded Marker for Imaging of Internal Plasmodium Membranes
Molecular Microbiology, Volume 126, Issue 4, Page 462-472, October 2026.IMMP is a peptide‐based marker that labels internal membranes across multiple stages and species of the malaria‐causing parasite Plasmodium. It works in both live and fixed samples and supports long‐term live‐cell imaging. ABSTRACT Fluorescence microscopy is a powerful tool to analyze the subcellular architecture, and long‐term live‐cell imaging ...
Leah Zink +9 more
wiley +1 more source
Babesia bigemina: Isolation and Characterization of Merozoite Rhoptries
Experimental Parasitology, 1993 Babesia bigemina apical membrane polypeptide p58, encoded by a multigene family with homologues in other Babesia spp. and sequence similarity to rhoptry proteins in other apicomplexan parasites, was identified within merozoite rhoptries using immunoelectron microscopy. To identify additional B.
Machado, Rosangela Z. +4 more
openaire +4 more sources
Rhoptry antigens asToxoplasma gondiivaccine target [PDF]
Clinical and Experimental Vaccine Research, 2019 Toxoplasmosis is a cosmopolitan zoonotic infection, caused by a unicellular protozoan parasite known as Toxoplasma gondii that belongs to the phylum Apicomplexa. It is estimated that over one-third of the world's population has been exposed and are latently infected with the parasite.
Masoud Foroutan +4 more
openaire +2 more sources
TgDHHC7 is required for apical rhoptry docking.
, 2013 (A–C) IFA detecting the rhoptry body protein ROP2/3/4 and rhoptry neck protein RON11. (A) During normal rhoptry biogenesis, 6–14 rhoptries are generated, each with a polarized morphology consisting of a posterior, bulbous body and tapered anterior neck ...
Peter J. Bradley (225949) +6 more
core +1 more source
Plasmodium Actin‐Like Proteins 3 and 5a Are Required for Subsequent Steps of Mosquito Infection
Molecular Microbiology, Volume 126, Issue 4, Page 451-461, October 2026.Actin‐like proteins (Alps) are highly conserved, apicomplexan‐specific members of the actin superfamily. Using reverse genetics, we have identified that Alp3 and Alp5a are required at separate steps of transmission of the malaria parasite to its mosquito host.
Caroline Busse +5 more
wiley +1 more source
Protection against Toxoplasma gondii cysts in pigs immunized with rROP2 plus Iscomatrix
Revista Brasileira de Parasitologia Veterinária, 2020 This study aimed to evaluate the humoral immune response in pigs immunized intranasally and intramuscularly with recombinant Toxoplasma gondii rROP2 protein in combination with the adjuvant Iscomatrix. Twelve mixed breed pigs divided into three groups (n=
Ivo Alexandre Leme da Cunha +7 more
doaj +1 more source
A Toxoplasma palmitoyl acyl transferase and the palmitoylated armadillo repeat protein TgARO govern apical rhoptry tethering and reveal a critical role for the rhoptries in host cell invasion but not egress. [PDF]
PLoS Pathogens, 2013 Apicomplexans are obligate intracellular parasites that actively penetrate their host cells to create an intracellular niche for replication. Commitment to invasion is thought to be mediated by the rhoptries, specialized apical secretory organelles that ...
Josh R Beck +6 more
doaj +1 more source
ChemMedChem, Volume 21, Issue 15, 14 August 2026.A structure‐informed, fragment‐based approach was used to identify non‐peptidomimetic inhibitors of plasmepsin V. Pyrrolidine, piperidine, and piperazine containing fragments showed activity in a FRET assay. The optimization of the pyrrolidine scaffold resulted in N‐sulfonamide analogs with potency up to ~10 µM, establishing a promising scaffold for ...
Marija Skvorcova +4 more
wiley +1 more source
Molecular Ecology Resources, Volume 26, Issue 5, July 2026.ABSTRACT Avian malaria, caused by Plasmodium parasites, poses a significant threat to bird populations worldwide, particularly in vulnerable island ecosystems. Yet, progress in understanding avian malaria transmission dynamics has been hampered by the lack of molecular tools to quantify and sex the transmissible stages of the parasite: the male and ...
A. Berthomieu +5 more
wiley +1 more source
Distinct external signals trigger sequential release of apical organelles during erythrocyte invasion by malaria parasites. [PDF]
PLoS Pathogens, 2010 The invasion of erythrocytes by Plasmodium merozoites requires specific interactions between host receptors and parasite ligands. Parasite proteins that bind erythrocyte receptors during invasion are localized in apical organelles called micronemes and ...
Shailja Singh +4 more
doaj +1 more source