Results 81 to 90 of about 5,406 (212)

Is Toxoplasma gondii‐secreted Protein With an Altered Thrombospondin Repeat (TgSPATR) a Potential Candidate for Immunisation? An Immunoinformatics‐Based Analysis

Veterinary Medicine and Science, Volume 12, Issue 1, January 2026.
Toxoplasma gondii‐secreted protein with an altered thrombospondin repeat was computationally characterised as an immunogenic, non‐allergenic protein carrying multiple B‐ and T‐cell epitopes. Structural validation and immune simulation suggest its strong potential as a vaccine candidate against toxoplasmosis.
Masoud Foroutan, Elaheh Karimzadeh‐Soureshjani, Fatemeh Ghaffarifar   +2 more
wiley   +1 more source

Isolation and Proteomic Analysis of Rhoptry-Enriched Fractions from Cryptosporidium parvum

Iranian Journal of Public Health, 2015
Background: Rhoptries are unique secretory/excretory organelles that are found exclusively in the Apicomplexa, and their contents are discharged at the time of invasion and are critical in the establishment of productive infection.
Yan HUANG, Rongsheng MI, Wei CAO, Peng ZHOU, Kai SHI, Xiaojiao YANG, Xiaojuan WANG, Xiangpei WANG, Zhaoguo CHEN   +8 more
doaj  

Toxoplasma gondii: humoral and cellular immune response of BALB/c mice immunized via intranasal route with rTgROP2 Toxoplasma gondii: avaliação da resposta imune humoral e celular de camundongos BALB/c imunizados pela via nasal com rTgROP2

Revista Brasileira de Parasitologia Veterinária, 2010
TgROP2 is an intracellular protein associated with rhoptries of Toxoplama gondii and an antigen component of a candidate vaccine for toxoplasmosis. The purpose of the present study was to evaluate the efficacy of rTgROP2 to stimulate humoral and cellular
Michelle Igarashi, Dauton Luiz Zulpo, Ivo Alexandre Leme da Cunha, Luiz Daniel Barros, Vanessa Figueredo Pereira, Alessandra Taroda, Italmar Teodorico Navarro, Odilon Vidotto, Marilda Carlos Vidotto, Mark Christopher Jenkins, João Luis Garcia   +10 more
doaj   +1 more source

Toxoplasmosis: Epidemiological Significance, Economic Burden, and Emerging Directions in Drug Discovery and Artificial Intelligence

International Journal of Microbiology, Volume 2026, Issue 1, 2026.
Toxoplasmosis, a parasitic disease caused by Toxoplasma gondii, affects a wide range of warm‐blooded hosts and remains most prevalent in tropical regions, with distribution shaped by climate, cultural practices, and environmental conditions. Clinical severity varies across susceptible populations, generating substantial economic burdens through medical
Albert Fynn Aiduenu, Blessing Kwabena Gayi, Aboagye Kwarteng Dofuor, Susanna Awinsongya Anovunga, William Ekloh, Joseph Harold Nyarko Osei, Christopher Nii Laryea Tawiah-Mensah, Juliet Ama Mawusi Koudonu Seglah, Jennifer Afua Afrifa Yamoah, Angelina Akomea, Andy Asafu-Adjaye, Shih Keng Loong   +11 more
wiley   +1 more source

Rhoptry secretion system structure and priming in Plasmodium falciparum revealed using in situ cryo-electron tomography

, 2022
Apicomplexan parasites secrete contents of the rhoptries, club-shaped organelles in the apical region, into host cells to permit their invasion and establishment of infection. The rhoptry secretory apparatus (RSA), which is critical for rhoptry secretion,
Guérin, Amandine, Martinez, Matthew, Lebrun, Maryse, Mageswaran, Shrawan Kumar, John, Audrey R. Odom, Chang, Yi-Wei, Chen, William David, Molnár, Petra, Cova, Marta Mendonça, Chen, William, David, John, Audrey, R Odom, Mageswaran, Shrawan, Kumar, Cova, Marta, Mendonça, Matthew Martinez, Audrey R. Odom John, Maryse Lebrun, Yi-Wei Chang, Petra Molnár, Marta Mendonça Cova, Shrawan Kumar Mageswaran, William David Chen, Amandine Guérin   +21 more
core   +1 more source

Inhibition of protein N-myristoylation blocks Plasmodium falciparum intraerythrocytic development, egress and invasion.

PLoS Biology, 2021
We have combined chemical biology and genetic modification approaches to investigate the importance of protein myristoylation in the human malaria parasite, Plasmodium falciparum.
Anja C Schlott, Ellen Knuepfer, Judith L Green, Philip Hobson, Aaron J Borg, Julia Morales-Sanfrutos, Abigail J Perrin, Catherine Maclachlan, Lucy M Collinson, Ambrosius P Snijders, Edward W Tate, Anthony A Holder   +11 more
doaj   +1 more source

Evidence for the Nucleo-Apical Shuttling of a Beta-Catenin Like Plasmodium falciparum Armadillo Repeat Containing Protein. [PDF]

PLoS ONE, 2016
Eukaryotic Armadillo (ARM) repeat proteins are multifaceted with prominent roles in cell-cell adhesion, cytoskeletal regulation and intracellular signaling among many others.
Pallabi Mitra, Enna Dogra Gupta, Tajali Sahar, Alok K Pandey, Poonam Dangi, K Sony Reddy, Virander Singh Chauhan, Deepak Gaur   +7 more
doaj   +1 more source

Nanoparticle‐Based Vaccines Against Toxoplasma gondii: Immunological Rationale, Platform Strategies, and Translational Challenges

Transboundary and Emerging Diseases, Volume 2026, Issue 1, 2026.
Toxoplasma gondii is a widely distributed zoonotic pathogen with detrimental impacts on both human health and livestock production. No vaccine is available for humans, and the only licensed veterinary vaccine, Toxovax, has limitations related to safety, stability, and large‐scale production.
Xiaoyu Sang, Yutong Zhang, Fangqi Sun, Yanting Jin, Hua Zhang, Ying Feng, Hany M. El-Wahsh, Sara Farag, Ebtesam Al-Olayan, Beniamino Cenci Goga, Na Yang, Saeed El-Ashram, Xiangrui Li   +12 more
wiley   +1 more source

Cryogenic electron tomography reveals novel structures in the apical complex of Plasmodium falciparum

mBio
Intracellular infectious agents, like the malaria parasite, Plasmodium falciparum, face the daunting challenge of how to invade a host cell. This problem may be even harder when the host cell in question is the enucleated red blood cell, which lacks the ...
Stella Y. Sun, Li-av Segev-Zarko, Grigore D. Pintilie, Chi Yong Kim, Sophia R. Staggers, Michael F. Schmid, Elizabeth S. Egan, Wah Chiu, John C. Boothroyd   +8 more
doaj   +1 more source

Toxoplasma gondii KCR is a Noncanonical Modulator of CSF2 Signaling that Targets the CSF2Rα–JAK2/STAT5 Axis

Transboundary and Emerging Diseases, Volume 2026, Issue 1, 2026.
Toxoplasma gondii establishes infection in hosts by deploying effector proteins that reprogram cytokine‐driven immunity. While protozoan parasite‐encoded macrophage migration inhibitory factor (MIF) homologs exemplify cytokine mimicry, whether T. gondii targets additional host cytokine axes remains unclear. Here, we identify a T.
Jie Mei, Xianglin Pu, Mengkai Zhang, Yue Liu, Chuang Meng, Lixin Xu, Xiaokai Song, Ruofeng Yan, Xiangrui Li, Mingmin Lu, Linzhu Ren   +10 more
wiley   +1 more source