Results 41 to 50 of about 5,406 (212)

The Mechanism of Action of Ursolic Acid as a Potential Anti-Toxoplasmosis Agent, and Its Immunomodulatory Effects

Pathogens, 2019
This study was performed to investigate the mechanism of action of ursolic acid in terms of anti-Toxoplasma gondii effects, including immunomodulatory effects. We evaluated the anti-T. gondii effects of ursolic acid, and analyzed the production of nitric
Won Hyung Choi, In Ah Lee
doaj   +1 more source

Ferlins and TgDOC2 in Toxoplasma Microneme, Rhoptry and Dense Granule Secretion

Life, 2021
The host cell invasion process of apicomplexan parasites like Toxoplasma gondii is facilitated by sequential exocytosis of the microneme, rhoptry and dense granule organelles. Exocytosis is facilitated by a double C2 domain (DOC2) protein family.
Daniel N. A. Tagoe, Allison A. Drozda, Julia A. Falco, Tyler J. Bechtel, Eranthie Weerapana, Marc-Jan Gubbels   +5 more
doaj   +1 more source

Roles of the RON3 C-terminal fragment in erythrocyte invasion and blood-stage parasite proliferation in Plasmodium falciparum

Frontiers in Cellular and Infection Microbiology, 2023
Plasmodium species cause malaria, and in the instance of Plasmodium falciparum is responsible for a societal burden of over 600,000 deaths annually. The symptoms and pathology of malaria are due to intraerythocytic parasites.
Daisuke Ito, Yoko Kondo, Eizo Takashima, Hideyuki Iriko, Amporn Thongkukiatkul, Motomi Torii, Hitoshi Otsuki   +6 more
doaj   +1 more source

The Rhoptry Pseudokinase ROP54 Modulates Toxoplasma gondii Virulence and Host GBP2 Loading

mSphere, 2016
Toxoplasma gondii uses unique secretory organelles called rhoptries to inject an array of effector proteins into the host cytoplasm that hijack host cell functions.
Elliot W. Kim, Santhosh M. Nadipuram, Ashley L. Tetlow, William D. Barshop, Philip T. Liu, James A. Wohlschlegel, Peter J. Bradley   +6 more
doaj   +1 more source

In situ ultrastructures of two evolutionarily distant apicomplexan rhoptry secretion systems

, 2021
International audienceParasites of the phylum Apicomplexa cause important diseases including malaria, cryptosporidiosis and toxoplasmosis. These intracellular pathogens inject the contents of an essential organelle, the rhoptry, into host cells to ...
Chen, William, David, Guérin, Amandine, Martinez, Matthew, Lebrun, Maryse, Mageswaran, Shrawan, Kumar, Striepen, Boris, Chang, Yi-Wei, Theveny, Liam, M   +7 more
core   +2 more sources

Plasmodium falciparum parasites deploy RhopH2 into the host erythrocyte to obtain nutrients, grow and replicate

eLife, 2017
Plasmodium falciparum parasites, the causative agents of malaria, modify their host erythrocyte to render them permeable to supplementary nutrient uptake from the plasma and for removal of toxic waste.
Natalie A Counihan, Scott A Chisholm, Hayley E Bullen, Anubhav Srivastava, Paul R Sanders, Thorey K Jonsdottir, Greta E Weiss, Sreejoyee Ghosh, Brendan S Crabb, Darren J Creek, Paul R Gilson, Tania F de Koning-Ward   +11 more
doaj   +1 more source

A rhoptry protein, localizing in the bulb region of rhoptries, could induce protective immunity against Eimeria tenella infection

Frontiers in Immunology, 2023
BackgroundRhoptry organelle proteins (ROPs) secreted by apicomplexan parasites play important roles during parasites invasion and survival in host cells, and are potential vaccine candidates against apicomplexan diseases. Eimeria tenella (E. tenella) is one of the most noteworthy apicomplexan species, which causes hemorrhagic pathologies.
Tuan-yuan Shi, Si-han Zhou, Si-han Zhou, Ya-ru Kong, Ya-ru Kong, Yuan Fu, Yan Liu, Wen-chao Yan, Yong-xue Zhou, Liang Zhang, Li-li Hao, Hong-chao Sun   +11 more
openaire   +3 more sources

The persistence of naturally acquired antibodies and memory B cells specific to rhoptry proteins of Plasmodium vivax in patients from areas of low malaria transmission

Malaria Journal, 2019
Background Rhoptries are the large, paired, secretory organelles located at the apical tip of the malaria merozoite that are considered important for parasite invasion processes.
Piyawan Kochayoo, Siriruk Changrob, Kittikorn Wangriatisak, Seong Kyun Lee, Patchanee Chootong, Eun-Taek Han   +5 more
doaj   +1 more source

mAb 2A7 recognizes a rhoptry neck protein.

, 2012
(A) Co-immunofluorescence-staining on intracellular tachyzoites with the rhoptry bulb marker anti-ROP1, the rhoptry neck marker RON2 and mAb 2A7. Scale bar = 5 µm. (B) Electron microscopy of T.
Gaelle Lentini (179295), Alexander W. Pfaff (179297), Julien Papoin (179290), Ermanno Candolfi (179298), Maryse Lebrun (24550), Jean-François Dubremetz (111711), Mauld H. Lamarque (156490), Anne-Laure Finizio (179292)   +7 more
core   +1 more source

Characterisation of an electron lucent rhoptry in an intracellular or invading sporozoite.

, 2022
A: Slice from a Transmission electron microscopy image illustrating an invading or intracellular sporozoite with an electron lucent rhoptry (ELR) (box and A: inset) close to a host cell nucleus (30 min post-infection sample) scale bar 1μm; A: inset ...
Alana Burrell (6314069), Virginia Marugan-Hernandez (3445442), Flavia Moreira-Leite (5924531), Sue Vaughan (20216), Richard Wheeler (4449133), Fiona M. Tomley (7381571), David J. P. Ferguson (7484639)   +6 more
core   +1 more source