Results 11 to 20 of about 5,406 (212)

Identification of rhoptry trafficking determinants and evidence for a novel sorting mechanism in the malaria parasite Plasmodium falciparum. [PDF]

PLoS Pathogens, 2009
The rhoptry of the malaria parasite Plasmodium falciparum is an unusual secretory organelle that is thought to be related to secretory lysosomes in higher eukaryotes.
Dave Richard, Lev M Kats, Christine Langer, Casilda G Black, Khosse Mitri, Justin A Boddey, Alan F Cowman, Ross L Coppel   +7 more
doaj   +3 more sources

Functional Characterization of the Thrombospondin-Related Paralogous Proteins Rhoptry Discharge Factors 1 and 2 Unveils Phenotypic Plasticity in Toxoplasma gondii Rhoptry Exocytosis

Frontiers in Microbiology, 2022
To gain access to the intracellular cytoplasmic niche essential for their growth and replication, apicomplexan parasites such as Toxoplasma gondii rely on the timely secretion of two types of apical organelles named micronemes and rhoptries.
Alessia Possenti, Manlio Di Cristina, Chiara Nicastro, Matteo Lunghi, Valeria Messina, Federica Piro, Lorenzo Tramontana, Simona Cherchi, Mario Falchi, Lucia Bertuccini, Furio Spano   +10 more
doaj   +2 more sources

Identification of a novel rhoptry protein expressed predominantly in Plasmodium sporozoites [PDF]

Frontiers in Cellular and Infection Microbiology
The infective stages of apicomplexan protozoans, such as the malaria parasite Plasmodium, possess apical organelles rhoptries and micronemes, which contain secretory proteins required for host cell invasion.
Sunti Oundavong, Takashi Sekine, Motomi Torii, Tatsuhiko Ozawa, Tatsuhiko Ozawa, Hidetaka Kosako, Naoaki Shinzawa, Tomoko Ishino   +7 more
doaj   +2 more sources

The rhoptry proteome of Eimeria tenella sporozoites

International Journal for Parasitology, 2013
Proteins derived from the rhoptry secretory organelles are crucial for the invasion and survival of apicomplexan parasites within host cells. The rhoptries are club-shaped organelles that contain two distinct subpopulations of proteins that localise to separate compartments of the organelle.
Oakes, Richard D., Kurian, Dominic, Bromley, Elizabeth V., Ward, Chris, Lal, Kalpana, Blake, Damer P., Reid, Adam James, Pain, Arnab, Sinden, Robert E., Wastling, Jonathan M., Tomley, F. M. M Fiona   +10 more
core   +7 more sources

Cryptosporidium parvum CpARO marks rhoptry envelope remnants associated with feeder organelle formation [PDF]

Virulence
Apicomplexans encode a single armadillo repeat-only (ARO) protein, exemplified by TgARO and PfARO, that anchors to the rhoptry envelope through N-terminal acylation and supports rhoptry positioning through interaction with an ARO-interacting protein (AIP)
Ying Zhang, Chenchen Wang, Xin Zhao, Xiaodong Wu, Jigang Yin, Guan Zhu   +5 more
doaj   +2 more sources

Plasmodium RON11 triggers biogenesis of the merozoite rhoptry pair and is essential for erythrocyte invasion. [PDF]

PLoS Biology
Malaria is a global and deadly human disease caused by the apicomplexan parasites of the genus Plasmodium. Parasite proliferation within human red blood cells (RBCs) is associated with the clinical manifestations of the disease.
David Anaguano, Opeoluwa Adewale-Fasoro, Grace W Vick, Sean Yanik, James Blauwkamp, Manuel A Fierro, Sabrina Absalon, Prakash Srinivasan, Vasant Muralidharan   +8 more
doaj   +3 more sources

A lipid-binding protein mediates rhoptry discharge and invasion in Plasmodium falciparum and Toxoplasma gondii parasites [PDF]

Nature Communications, 2019
Plasmodium and Toxoplasma parasites rely on rhoptry exocytosis for invasion, but the underlying mechanism is not known. Here, Suarez et al. characterize rhoptry apical surface proteins (RASP) that localize to the rhoptry cap and bind charged lipids, and ...
Catherine Suarez, Gaëlle Lentini, Raghavendran Ramaswamy, Marjorie Maynadier, Eleonora Aquilini, Laurence Berry-Sterkers, Michael Cipriano, Allan L. Chen, Peter Bradley, Boris Striepen, Martin J. Boulanger, Maryse Lebrun   +11 more
doaj   +2 more sources

Clustering of host N-glycans by the microneme MIC1/4/6 complex licenses Toxoplasma rhoptry discharge [PDF]

The EMBO Journal
To initiate the process of invasion, apicomplexan parasites must discharge the contents of specialized organelles called rhoptries into host cells. This process requires prior recognition and binding of the host cell by proteins released from another set
Dylan Valleau, Mudita Goyal, Justin M Roberts, Frances Male, Gary E Ward, Sebastian Lourido   +5 more
doaj   +2 more sources

PfCERLI1 is a conserved rhoptry associated protein essential for Plasmodium falciparum merozoite invasion of erythrocytes [PDF]

Nature Communications, 2020
Rhoptries are essential organelles for invasion of erythrocytes by Plasmodium. Here, the authors characterize the rhoptry-associated protein CERLI1 using quantitative super-resolution microscopy, showing that it is important for parasite invasion and ...
Benjamin Liffner, Sonja Frölich, Gary K. Heinemann, Boyin Liu, Stuart A. Ralph, Matthew W. A. Dixon, Tim-Wolf Gilberger, Danny W. Wilson   +7 more
doaj   +2 more sources

Unraveling the Elusive Rhoptry Exocytic Mechanism of Apicomplexa

Trends in Parasitology, 2021
Apicomplexan parasites are unicellular eukaryotes that invade the cells in which they proliferate. The development of genetic tools in Toxoplasma, and then in Plasmodium, in the 1990s allowed the first description of the molecular machinery used for motility and invasion, revealing a crucial role for two different secretory organelles, micronemes and ...
Sparvoli, Daniela, Lebrun, Maryse
openaire   +4 more sources