Results 91 to 100 of about 16,795 (248)

Synchrotron XRF Imaging Reveals Manganese Accumulation in the Golgi and Post‐Synapses of Neurons and Enhanced Uptake in Astrocytes

Advanced Science, EarlyView.
Despite widespread exposure, the mechanisms of manganese neurotoxicity remain poorly understood. Using correlative cryogenic fluorescence and synchrotron X‐ray fluorescence imaging techniques, we show that the Golgi apparatus is the primary accumulation site for manganese in both neurons and astrocytes, and that manganese targets the neuronal ...
Ines Kelkoul, Aiyarin Kittilukkana, Luis C. C. Huarte, Hiram Castillo‐Michel, Murielle Salome, Stéphane Roudeau, Pauline Belzanne, Matthieu Sainlos, Noémie Pied, Monica Fernandez‐Monreal, Daniel Choquet, Richard Ortega, Asuncion Carmona   +12 more
wiley   +1 more source

Probing the role of the C2F domain of otoferlin

Frontiers in Molecular Neuroscience, 2023
Afferent synapses of cochlear inner hair cells (IHCs) employ a unique molecular machinery. Otoferlin is a key player in this machinery, and its genetic defects cause human auditory synaptopathy.
Han Chen, Han Chen, Han Chen, Han Chen, Qinghua Fang, Qinghua Fang, Qinghua Fang, Fritz Benseler, Nils Brose, Nils Brose, Nils Brose, Tobias Moser, Tobias Moser, Tobias Moser, Tobias Moser   +14 more
doaj   +1 more source

Synaptic vesicle dynamics in mouse rod bipolar cells. [PDF]

, 2008
To better understand synaptic signaling at the mammalian rod bipolar cell terminal and pave the way for applying genetic approaches to the study of visual information processing in the mammalian retina, synaptic vesicle dynamics and intraterminal calcium
Heidelberger, Ruth, Vila, Alejandro, Wan, Qun-Fang, Zhou, Zhen-Yu   +3 more
core   +1 more source

Neurotransmitter release at ribbon synapses in the retina

Immunology & Cell Biology, 2000
The synapses of photoreceptors and bipolar cells in the retina are easily identified ultrastructurally by the presence of synaptic ribbons, electron‐dense bars perpendicular to the plasma membrane at the active zones, extending about 0.5 μm into the cytoplasm.
openaire   +2 more sources

Molecular dissection of the photoreceptor ribbon synapse [PDF]

The Journal of Cell Biology, 2005
The ribbon complex of retinal photoreceptor synapses represents a specialization of the cytomatrix at the active zone (CAZ) present at conventional synapses. In mice deficient for the CAZ protein Bassoon, ribbons are not anchored to the presynaptic membrane but float freely in the cytoplasm.
Susanne tom Dieck, Wilko D. Altrock, Michael M. Kessels, Britta Qualmann, Hanna Regus, Dana Brauner, Anna Fejtová, Oliver Bracko, Eckart D. Gundelfinger, Johann H. Brandstätter   +9 more
openaire   +1 more source

Endoplasmic Reticulum Geometry Dictates Neuronal Bursting via Calcium Store Refill Rates and Exposes Selective Neuronal Vulnerability

Advanced Science, EarlyView.
The ER's continuous tubular network is maintained by ER‐shaping proteins whose mutation or dysregulation contributes to neurodegenerative diseases. Here, we show that ER morphology sets the speed of Ca2+ store replenishment between firing events. Disrupting ER continuity slows intra‐ER Ca2+ redistribution from extracellular refill (SOCE) sites, driving
Valentina Davi, Pierre Parutto, Yuyi Zhang, Tasuku Konno, Cecile Crapart, Raquel Pereira, John P. Franklin, Mosab Ali Awadelkareem, Daniel C Maddison, Michael J. Devine, Edgar R. Gomes, Joseph Chambers, Elena Koslover, Edward Avezov   +13 more
wiley   +1 more source

An Introduction to Predictive Processing Models of Perception and Decision‐Making

Topics in Cognitive Science, EarlyView., 2023
Abstract The predictive processing framework includes a broad set of ideas, which might be articulated and developed in a variety of ways, concerning how the brain may leverage predictive models when implementing perception, cognition, decision‐making, and motor control.
Mark Sprevak, Ryan Smith
wiley   +1 more source

New England Overview: A Guide to Large-Scale Energy Infrastructure Issues in 2015 [PDF]

, 2015
The report outlines how regional electricity and natural gas infrastructure decisions are made. It examines the current proposals to expand electricity transmission lines and natural gas pipelines into New England, as solutions to electricity and gas ...
Jonathan Raab, Paul Peterson
core  

Photoreceptor Outer Segment-like Structures in Long-Term 3D Retinas from Human Pluripotent Stem Cells. [PDF]

, 2017
The retinal degenerative diseases, which together constitute a leading cause of hereditary blindness worldwide, are largely untreatable. Development of reliable methods to culture complex retinal tissues from human pluripotent stem cells (hPSCs) could ...
Angueyra, Juan M, Ball, John, Grebe, Rhonda, Jones, Bryan W, Kim, Catherine, Li, Wei, Maruotti, Julien A, Sripathi, Srinivasa R, Wahlin, Karl J, Zack, Donald J   +9 more
core   +1 more source

Studying Macromolecular Composition in Cell–Cell Interfaces Using 3D Membrane Reconstitution Systems

Advanced Science, EarlyView.
A comprehensive understanding of the interactions between proteins, lipids and glycocalyx components at the immune synapse is still lacking. Here, an artificial and a semi‐artificial model contact system were established to reconstitute the cell‐cell contact in 3D. The model systems enable the examination of macromolecule enrichment or depletion at the
Franziska Ragaller, Amelie Maribel Schneider, Ellen Sjule, Renhua Sun, Xiao Han, Luca Andronico, Edward Jenkins, Michael Dustin, Adnane Achour, Erdinc Sezgin   +9 more
wiley   +1 more source