Rod Bipolar Cells Require Horizontal Cells for Invagination Into the Terminals of Rod Photoreceptors
Frontiers in Cellular Neuroscience, 2019 In the central nervous system, neuronal processing relies on the precisely orchestrated formation of synapses during development. The first synapse of the visual system is a triad synapse, comprising photoreceptors, horizontal cells and bipolar cells ...
Lena Nemitz +4 more
doaj +1 more source
Rod photoreceptor ribbon synapses in DBA/2J mice show progressive age-related structural changes. [PDF]
PLoS ONE, 2012 The DBA/2J mouse is a commonly used animal model in glaucoma research. The eyes of DBA/2J mice show severe age-related changes that finally lead to the degeneration of retinal ganglion cells and the optic nerve.
Michaela Fuchs +6 more
doaj +1 more source
Synaptic Release Potentiation at Aging Auditory Ribbon Synapses [PDF]
Frontiers in Aging Neuroscience, 2020 Age-related hidden hearing loss is often described as a cochlear synaptopathy that results from a progressive degeneration of the inner hair cell (IHC) ribbon synapses. The functional changes occurring at these synapses during aging are not fully understood.
Thibault Peineau +7 more
openaire +4 more sources
Structural and Chemical Engineering of Sub‐Nanochannel Membranes Toward Ion Selectivity
Advanced Functional Materials, EarlyView.This review summarizes recent advances in structural and chemical engineering of sub‐nanochannels for ion selectivity. We first introduce fundamental ion transport mechanisms within sub‐nanochannels, followed by strategies to tune pore size, geometry, and surface functionalities, categorized into charge‐based, ion‐recognition, hydrophilic bonding, and ...
Yuyu Su +5 more
wiley +1 more source
Identification and immunocytochemical characterization of Piccolino, a novel Piccolo splice variant selectively expressed at sensory ribbon synapses of the eye and ear. [PDF]
PLoS ONE, 2013 Piccolo is one of the largest cytomatrix proteins present at active zones of chemical synapses, where it is suggested to play a role in recruiting and integrating molecules relevant for both synaptic vesicle exo- and endocytosis.
Hanna Regus-Leidig +9 more
doaj +1 more source
Opposing gradients of ribbon size and AMPA receptor expression underlie sensitivity differences among cochlear-nerve/hair-cell synapses [PDF]
, 2010 The auditory system transduces sound-evoked vibrations over a range of input sound pressure levels spanning six orders of magnitude. An important component of the system mediating this impressive dynamic range is established in the cochlear sensory ...
Liberman, Leslie D. +2 more
core +1 more source
Molecular Anatomy of the Hair Cell's Ribbon Synapse [PDF]
The Journal of Neuroscience, 2010 Hearing depends on reliable and temporally precise neurotransmission by cochlear hair cells. The wide dynamic range and high sensitivity with which these cells encode acoustic stimuli are associated with a presynaptic specialization termed the presynaptic dense body or synaptic ribbon.
Revathy C, Uthaiah, A J, Hudspeth
openaire +2 more sources
Advanced Healthcare Materials, EarlyView.Neural cell–derived small extracellular vesicles (sEVs) are emerging as pivotal mediators in neurodegenerative diseases, exerting both pathogenic and therapeutic functions. This review synthesizes current evidence on how sEVs from distinct neural cell types regulate neurodegeneration, neuroprotection, biomarker discovery, and targeted drug delivery ...
Muhammad Waqas Salim +4 more
wiley +1 more source
Association of Shank 1A Scaffolding Protein with Cone Photoreceptor Terminals in the Mammalian Retina [PDF]
, 2012 Photoreceptor terminals contain post-synaptic density (PSD) proteins e.g., PSD-95/PSD-93, but their role at photoreceptor synapses is not known. PSDs are generally restricted to post-synaptic boutons in central neurons and form scaffolding with multiple ...
Albert Y. Hung +8 more
core +6 more sources
Intracellular calcium stores drive slow non-ribbon vesicle release from rod photoreceptors
Frontiers in Cellular Neuroscience, 2014 Rods are capable of greater slow release than cones contributing to overall slower release kinetics. Slow release in rods involves Ca2+-induced Ca2+ release (CICR).
Minghui eChen +2 more
doaj +1 more source