Results 1 to 10 of about 20,821 (225)

Absence of synaptic regulation by phosducin in retinal slices. [PDF]

PLoS ONE, 2013
Phosducin is an abundant photoreceptor protein that binds G-protein βγ subunits and plays a role in modulating synaptic transmission at photoreceptor synapses under both dark-adapted and light-adapted conditions in vivo.
James H Long, Vadim Y Arshavsky, Marie E Burns   +2 more
doaj   +20 more sources

A dual role for Cav1.4 Ca2+ channels in the molecular and structural organization of the rod photoreceptor synapse [PDF]

eLife, 2020
Synapses are fundamental information processing units that rely on voltage-gated Ca2+ (Cav) channels to trigger Ca2+-dependent neurotransmitter release. Cav channels also play Ca2+-independent roles in other biological contexts, but whether they do so in
J Wesley Maddox, Kate L Randall, Ravi P Yadav, Brittany Williams, Jussara Hagen, Paul J Derr, Vasily Kerov, Luca Della Santina, Sheila A Baker, Nikolai Artemyev, Mrinalini Hoon, Amy Lee   +11 more
doaj   +2 more sources

Mechanisms of simultaneous linear and nonlinear computations at the mammalian cone photoreceptor synapse [PDF]

Nature Communications, 2023
Neurons enhance their computational power by combining linear and nonlinear transformations in extended dendritic trees. Rich, spatially distributed processing is rarely associated with individual synapses, but the cone photoreceptor synapse may be an ...
Chad P. Grabner, Daiki Futagi, Jun Shi, Vytas Bindokas, Katsunori Kitano, Eric A. Schwartz, Steven H. DeVries   +6 more
doaj   +2 more sources

Dysfunction of the glutamatergic photoreceptor synapse in the P301S mouse model of tauopathy [PDF]

Acta Neuropathologica Communications, 2023
Tauopathies, including Alzheimer’s disease, are characterized by retinal ganglion cell loss associated with amyloid and phosphorylated tau deposits. We investigated the functional impact of these histopathological alterations in the murine P301S model of
L. Arouche-Delaperche, S. Cadoni, C. Joffrois, G. Labernede, M. Valet, Q. César, J. Dégardin, S. Girardon, C. Gabriel, S. Krantic, S. Picaud   +10 more
doaj   +2 more sources

A non-conducting role of the Cav1.4 Ca2+ channel drives homeostatic plasticity at the cone photoreceptor synapse [PDF]

eLife
In congenital stationary night blindness, type 2 (CSNB2)—a disorder involving the Cav1.4 (L-type) Ca2+ channel—visual impairment is mild considering that Cav1.4 mediates synaptic release from rod and cone photoreceptors. Here, we addressed this conundrum
J Wesley Maddox, Gregory J Ordemann, Juan AM de la Rosa Vázquez, Angie Huang, Christof Gault, Serena R Wisner, Kate Randall, Daiki Futagi, Nihal A Salem, Dayne Mayfield, Boris V Zemelman, Steven DeVries, Mrinalini Hoon, Amy Lee   +13 more
doaj   +2 more sources

Lrit1, a Retinal Transmembrane Protein, Regulates Selective Synapse Formation in Cone Photoreceptor Cells and Visual Acuity

Cell Reports, 2018
Summary: In the vertebrate retina, cone photoreceptors play crucial roles in photopic vision by transmitting light-evoked signals to ON- and/or OFF-bipolar cells.
Yoshihiro Omori, Satoshi Watanabe, Taro Chaya   +2 more
exaly   +3 more sources

Afadin-deficient mouse retinas exhibit severe neuronal lamination defects but preserve visual functions [PDF]

eLife
Neural lamination is a common feature of the CNS, with several subcellular structures, such as adherens junctions (AJs), playing a role in this process.
Akiko Ueno, Konan Sakuta, Hiroki Ono, Aki Hashio, Haruki Tokumoto, Mikiya Watanabe, Taketo Nishimoto, Toru Konishi, Yuki Emori, Shunsuke Mizuno, Mao Hiratsuka, Jun Miyoshi, Yoshimi Takai, Masao Tachibana, Chieko Koike   +14 more
doaj   +2 more sources

Afferent input differentially regulates establishment and maintenance of synapses in the mammalian retina [PDF]

Scientific Reports
How afferent input shapes synaptic connections is fundamental to our understanding of cues that govern assembly of sensory circuits. In the retina, photoreceptors provide afferent visual information to second-order bipolar cells (BCs) that in turn ...
Julie Wallin, Andrew Miller, Raunak Sinha, Mrinalini Hoon   +3 more
doaj   +2 more sources

Early degeneration of photoreceptor synapse inCcl2/Cx3cr1-deficient mice onCrb1rd8background [PDF]

Synapse, 2013
Jingsheng Tuo, DeFen Shen, Chi-Chao Chan
exaly   +2 more sources

Regional variation in the organization and connectivity of the first synapse in the primate night vision pathway

iScience, 2023
Summary: Sensitivity of primate daylight vision varies across the visual field. This is attributed to regional variations in cone photoreceptor density and synaptic connectivity of the underlying circuitry.
Aindrila Saha, Juan Zuniga, Kainat Mian, Haoshen Zhai, Paul J. Derr, Mrinalini Hoon, Raunak Sinha   +6 more
doaj   +1 more source