LKB1 coordinates neurite remodeling to drive synapse layer emergence in the outer retina
eLife, 2020 Structural changes in pre and postsynaptic neurons that accompany synapse formation often temporally and spatially overlap. Thus, it has been difficult to resolve which processes drive patterned connectivity.
Courtney A Burger +8 more
doaj +1 more source
Rod photoreceptor ribbon synapses in DBA/2J mice show progressive age-related structural changes. [PDF]
PLoS ONE, 2012 The DBA/2J mouse is a commonly used animal model in glaucoma research. The eyes of DBA/2J mice show severe age-related changes that finally lead to the degeneration of retinal ganglion cells and the optic nerve.
Michaela Fuchs +6 more
doaj +1 more source
Encoding Light Intensity by the Cone Photoreceptor Synapse [PDF]
Neuron, 2005 How cone synapses encode light intensity determines the precision of information transmission at the first synapse on the visual pathway. Although it is known that cone photoreceptors hyperpolarize to light over 4-5 log units of intensity, the relationship between light intensity and transmitter release at the cone synapse has not been determined. Here,
Sue-Yeon, Choi +6 more
openaire +3 more sources
A positive feedback synapse from retinal horizontal cells to cone photoreceptors. [PDF]
PLoS Biology, 2011 Cone photoreceptors and horizontal cells (HCs) have a reciprocal synapse that underlies lateral inhibition and establishes the antagonistic center-surround organization of the visual system.
Skyler L Jackman +4 more
doaj +1 more source
Endophilin-B regulates autophagy during synapse development and neurodegeneration
Neurobiology of Disease, 2022 Synapses are critical for neuronal communication and brain function. To maintain neuronal homeostasis, synapses rely on autophagy. Autophagic alterations cause neurodegeneration and synaptic dysfunction is a feature in neurodegenerative diseases.
Sergio Hernandez-Diaz +7 more
doaj +1 more source
Neural superposition and oscillations in the eye of the blowfly [PDF]
, 1987 Neural superposition in the eye of the blowfly Calliphora erythrocephala was investigated by stimulating single photoreceptors using corneal neutralization through water immersion.
D Burkhardt +18 more
core +2 more sources
Presynaptic [Ca2+] and GCAPs: aspects on the structure and function of photoreceptor ribbon synapses
Frontiers in Molecular Neuroscience, 2014 Changes in intracellular calcium ions [Ca2+] play important roles in photoreceptor signalling. Consequently, intracellular [Ca2+] levels need to be tightly controlled.
Frank eSchmitz
doaj +1 more source
Cis-regulatory basis of sister cell type divergence in the vertebrate retina [PDF]
, 2019 Multicellular organisms evolved via repeated functional divergence of transcriptionally related sister cell types, but the mechanisms underlying sister cell type divergence are not well understood.
Corbo, Joseph C +4 more
core +3 more sources
All oxide based flexible multi-folded invisible synapse as vision photo-receptor
Scientific Reports, 2023 All oxide-based transparent flexible memristor is prioritized for the potential application in artificially simulated biological optoelectronic synaptic devices.
Ping-Xing Chen +2 more
doaj +1 more source
Disease Models & Mechanisms, 2021 Blindness associated with Usher syndrome type 1 (USH1) is typically characterized as rod photoreceptor degeneration, followed by secondary loss of cones.
Amanda Miles +3 more
doaj +1 more source