Synaptic vesicle release during ribbon synapse formation of cone photoreceptors [PDF]
Frontiers in Cellular Neuroscience, 2022 Mammalian cone photoreceptors enable through their sophisticated synapse the high-fidelity transfer of visual information to second-order neurons in the retina.
Kaspar Gierke +2 more
exaly +4 more sources
Cochlear ribbon synapse maturation requires Nlgn1 and Nlgn3 [PDF]
iScience, 2022 Summary: Hearing depends on precise synaptic transmission between cochlear inner hair cells and spiral ganglion neurons through afferent ribbon synapses.Neuroligins (Nlgns) facilitate synapse maturation in the brain, but they have gone unstudied in the ...
Miguel A. Ramirez +10 more
doaj +2 more sources
Excess extracellular K+ causes inner hair cell ribbon synapse degeneration [PDF]
Communications Biology, 2021 Zhao et al. demonstrate the effect of elevated extracellular K + on hidden hearing loss in mice, and the consequent effect on inner hair cell ribbon synapse loss. Their results indicate that BK potassium channels could be a potential target for treatment
Hong-Bo Zhao, Yan Zhu, Li-Man Liu
doaj +2 more sources
L-type voltage-gated calcium channel agonists mitigate hearing loss and modify ribbon synapse morphology in the zebrafish model of Usher syndrome type 1 [PDF]
Disease Models & Mechanisms, 2020 The mariner (myo7aa−/−) mutant is a zebrafish model for Usher syndrome type 1 (USH1). To further characterize hair cell synaptic elements in myo7aa−/− mutants, we focused on the ribbon synapse and evaluated ultrastructure, number and distribution of ...
Alaa Koleilat +7 more
doaj +2 more sources
The presynaptic ribbon maintains vesicle populations at the hair cell afferent fiber synapse [PDF]
eLife, 2018 The ribbon is the structural hallmark of cochlear inner hair cell (IHC) afferent synapses, yet its role in information transfer to spiral ganglion neurons (SGNs) remains unclear.
Lars Becker +8 more
doaj +4 more sources
Functional maturation of the rod bipolar to AII-amacrine cell ribbon synapse in the mouse retina [PDF]
Cell Reports, 2023 Summary: Retinal ribbon synapses undergo functional changes after eye opening that remain uncharacterized. Using light-flash stimulation and paired patch-clamp recordings, we examined the maturation of the ribbon synapse between rod bipolar cells (RBCs ...
Mean-Hwan Kim +5 more
doaj +2 more sources
Neurotrophin-3 regulates ribbon synapse density in the cochlea and induces synapse regeneration after acoustic trauma [PDF]
eLife, 2014 Neurotrophin-3 (Ntf3) and brain derived neurotrophic factor (Bdnf) are critical for sensory neuron survival and establishment of neuronal projections to sensory epithelia in the embryonic inner ear, but their postnatal functions remain poorly understood.
Guoqiang Wan +4 more
doaj +6 more sources
Mechanisms of synaptic depression at the hair cell ribbon synapse that support auditory nerve function. [PDF]
Proc Natl Acad Sci U S A, 2017 Inner hair cells (IHCs) in the cochlea are the mammalian phono-receptors, transducing sound energy into graded changes in membrane potentials, the so called “receptor potentials.” Ribbon synapses between IHCs and auditory nerve neurons are responsible ...
Goutman JD.
europepmc +3 more sources
N-Methyl-D-Aspartate Receptors Involvement in the Gentamicin-Induced Hearing Loss and Pathological Changes of Ribbon Synapse in the Mouse Cochlear Inner Hair Cells [PDF]
Neural Plasticity, 2018 Cochlear inner hair cell (IHC) ribbon synapses play an important role in sound encoding and neurotransmitter release. Previous reports show that both noise and aminoglycoside exposures lead to reduced numbers and morphologic changes of synaptic ribbons ...
Juan Hong +10 more
doaj +2 more sources
Disruption of Otoferlin Alters the Mode of Exocytosis at the Mouse Inner Hair Cell Ribbon Synapse [PDF]
Frontiers in Molecular Neuroscience, 2019 Sound encoding relies on Ca2+-mediated exocytosis at the ribbon synapse between cochlear inner hair cells (IHCs) and type I spiral ganglion neurons (SGNs).
Hideki Takago +11 more
doaj +2 more sources