Results 31 to 40 of about 16,795 (248)
Macrophages Are Dispensable for Postnatal Pruning of the Cochlear Ribbon Synapses
Frontiers in Cellular Neuroscience, 2021 Ribbon synapses of cochlear hair cells undergo pruning and maturation before the hearing onset. In the central nervous system (CNS), synaptic pruning was mediated by microglia, the brain-resident macrophages, via activation of the complement system ...
Chaorong Yu +8 more
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Protection of Cochlear Ribbon Synapses and Prevention of Hidden Hearing Loss
Neural Plasticity, 2020 In the auditory system, ribbon synapses are vesicle-associated structures located between inner hair cells (IHCs) and spiral ganglion neurons that are implicated in the modulation of trafficking and fusion of synaptic vesicles at the presynaptic ...
Mei Wei +5 more
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Sensory Processing at Ribbon Synapses in the Retina and the Cochlea [PDF]
Physiological Reviews, 2020 In recent years, sensory neuroscientists have made major efforts to dissect the structure and function of ribbon synapses which process sensory information in the eye and ear. This review aims to summarize our current understanding of two key aspects of ribbon synapses: 1) their mechanisms of exocytosis and endocytosis and 2) their molecular anatomy ...
Tobias Moser +2 more
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Distinct synaptic transfer functions in same-type photoreceptors
eLife, 2021 Many sensory systems use ribbon-type synapses to transmit their signals to downstream circuits. The properties of this synaptic transfer fundamentally dictate which aspects in the original stimulus will be accentuated or suppressed, thereby partially ...
Cornelius Schröder +4 more
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Quantitative Analysis Linking Inner Hair Cell Voltage Changes and Postsynaptic Conductance Change: A Modelling Study [PDF]
, 2015 This paper presents a computational model which estimates the postsynaptic conductance change of mammalian Type I afferent peripheral process when airborne acoustic waves impact on the tympanic membrane. A model of the human auditory periphery is used to
Drakakis, EM, Prokopiou, AN
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Transmitter release from cochlear hair cells is phase locked to cyclic stimuli of different intensities and frequencies [PDF]
, 2012 The auditory system processes time and intensity through separate brainstem pathways to derive spatial location as well as other salient features of sound.
Goutman, Juan Diego
core +1 more source
Frontiers in Molecular Neuroscience, 2022 In rodents, massive initial synapses are formed in the auditory peripheral nervous system at the early postnatal stage, and one of the major phenomena is that the number of afferent synapses in the cochlea is significantly reduced in the duration of ...
Rui Guo +8 more
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Synaptic mitochondria regulate hair-cell synapse size and function
eLife, 2019 Sensory hair cells in the ear utilize specialized ribbon synapses. These synapses are defined by electron-dense presynaptic structures called ribbons, composed primarily of the structural protein Ribeye.
Hiu-tung C Wong +5 more
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Endocytosis and Vesicle Recycling at a Ribbon Synapse [PDF]
The Journal of Neuroscience, 2003 At ribbon synapses, where exocytosis is regulated by graded depolarization, vesicles can fuse very rapidly with the plasma membrane (complete discharge of the releasable pool in ∼200 msec). Vesicles are also retrieved very rapidly (time constant of ∼1 sec), leading us to wonder whether their retrieval uses an unusual mechanism.
Christophe, Paillart +3 more
openaire +2 more sources
eLife, 2013 Information flow through neural circuits is determined by the nature of the synapses linking the subtypes of neurons. How neurons acquire features distinct to each synapse remains unknown.
Wei-Ming Yu +5 more
doaj +1 more source