The SNARE protein SNAP-25 is required for normal exocytosis at auditory hair cell ribbon synapses
iScience, 2022 Summary: Hearing depends on fast and sustained calcium-dependent synaptic vesicle fusion at the ribbon synapses of cochlear inner hair cells (IHCs). The implication of the canonical neuronal SNARE complex in this exocytotic process has so far remained ...
Charlotte Calvet +18 more
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The endocannabinoid/cannabinoid receptor 2 system protects against cisplatin-induced hearing loss [PDF]
, 2018 Previous studies have demonstrated the presence of cannabinoid 2 receptor (CB2R) in the rat cochlea which was induced by cisplatin. In an organ of Corti-derived cell culture model, it was also shown that an agonist of the CB2R protected these cells ...
Asmita Dhukhwa +8 more
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Synaptic transmission at retinal ribbon synapses [PDF]
Progress in Retinal and Eye Research, 2005 The molecular organization of ribbon synapses in photoreceptors and ON bipolar cells is reviewed in relation to the process of neurotransmitter release. The interactions between ribbon synapse-associated proteins, synaptic vesicle fusion machinery and the voltage-gated calcium channels that gate transmitter release at ribbon synapses are discussed in ...
Ruth, Heidelberger +2 more
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Calcium channel-dependent molecular maturation of photoreceptor synapses. [PDF]
PLoS ONE, 2013 Several studies have shown the importance of calcium channels in the development and/or maturation of synapses. The Ca(V)1.4(α(1F)) knockout mouse is a unique model to study the role of calcium channels in photoreceptor synapse formation.
Nawal Zabouri, Silke Haverkamp
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Enlargement of ribbons in zebrafish hair cells increases calcium currents, but disrupts afferent spontaneous activity and timing of stimulus onset. [PDF]
, 2017 In sensory hair cells of auditory and vestibular organs, the ribbon synapse is required for the precise encoding of a wide range of complex stimuli. Hair cells have a unique presynaptic structure-the synaptic ribbon-that organizes both synaptic vesicles ...
Beirl, A. +11 more
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The Synaptic Ribbon Is a Site of Phosphatidic Acid Generation in Ribbon Synapses [PDF]
The Journal of Neuroscience, 2011 Ribbon synapses continuously transmit graded membrane potential changes into changes of synaptic vesicle exocytosis and rely on intense synaptic membrane trafficking. The synaptic ribbon is considered central to this process. In the present study we asked whether tonically active ribbon synapses are associated with the generation of certain lipids ...
Schwarz, Karin +4 more
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Presynaptic [Ca2+] and GCAPs: aspects on the structure and function of photoreceptor ribbon synapses
Frontiers in Molecular Neuroscience, 2014 Changes in intracellular calcium ions [Ca2+] play important roles in photoreceptor signalling. Consequently, intracellular [Ca2+] levels need to be tightly controlled.
Frank eSchmitz
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A Pipeline for Volume Electron Microscopy of the Caenorhabditis elegans Nervous System. [PDF]
, 2018 The "connectome," a comprehensive wiring diagram of synaptic connectivity, is achieved through volume electron microscopy (vEM) analysis of an entire nervous system and all associated non-neuronal tissues. White et al.
Chisholm, Andrew D +7 more
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Why do axons differ in caliber? [PDF]
, 2012 CNS axons differ in diameter (d) by nearly 100-fold (∼0.1-10 μm); therefore, they differ in cross-sectional area (d(2)) and volume by nearly 10,000-fold.
Balasubramanian, Vijay +4 more
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Modelling of the auditory ribbon synapse [PDF]
Proceedings of Meetings on Acoustics, 2016 The coding of the fine temporal details of auditory stimuli by the auditory system is required for many auditory tasks, two renowned examples being pitch perception and sound source localization. The first stage where temporal information is processed is the auditory periphery.
Pablo E. Etchemendy +2 more
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