Results 61 to 70 of about 16,795 (248)

Striatin Is Required for Hearing and Affects Inner Hair Cells and Ribbon Synapses

Frontiers in Cell and Developmental Biology, 2020
Striatin, a subunit of the serine/threonine phosphatase PP2A, is a core member of the conserved striatin-interacting phosphatase and kinase (STRIPAK) complexes. The protein is expressed in the cell junctions between epithelial cells, which play a role in
Prathamesh T. Nadar-Ponniah, Prathamesh T. Nadar-Ponniah, Shahar Taiber, Michal Caspi, Tal Koffler-Brill, Amiel A. Dror, Amiel A. Dror, Ronen Siman-Tov, Moran Rubinstein, Moran Rubinstein, Krishnanand Padmanabhan, Chen Luxenburg, Richard A. Lang, Karen B. Avraham, Rina Rosin-Arbesfeld   +14 more
doaj   +1 more source

Dynamic assembly of ribbon synapses and circuit maintenance in a vertebrate sensory system [PDF]

Ribbon synapses transmit information in sensory systems, but their development is not well understood. To test the hypothesis that ribbon assembly stabilizes nascent synapses, we performed simultaneous time-lapse imaging of fluorescently-tagged ribbons ...
A Bleckert, A Keppler, A Suli, B Fell, C Lv, D Kerschensteiner, DA Fortin, DM Sherry, FA Dunn, FA Dunn, G Matthews, GJ Murphy, GW Schwartz, H Okawa, H Regus-Leidig, H Wässle, HM Sobkowicz, HV Friedman, J Snellman, JB Ke, JC Blanks, JE Dowling, JL Morgan, JL Morgan, JL Morgan, JL Puel, JW Olney, KA Martemyanov, L Lagnado, L Sheets, LJ Fisher, M Geppert, M Helmstaedter, M Midorikawa, MT Wong-Riley, NC Shaner, NW Tien, P Jean, P Koulen, P Koulen, P Washbourne, RE Marc, S Maxeiner, S Okabe, S Okabe, S Okabe, S Safieddine, SE Ahmari, SL Sabo, T Euler, T Moser, U Grünert, V Kerov, WN Grimes, WQ Yu, Y Goda, Y Nishimura, Y Tsukamoto, Y Wang, Z Chen   +59 more
core   +1 more source

Relating structure and function of inner hair cell ribbon synapses [PDF]

, 2015
In the mammalian cochlea, sound is encoded at synapses between inner hair cells (IHCs) and type I spiral ganglion neurons (SGNs). Each SGN receives input from a single IHC ribbon-type active zone (AZ) and yet SGNs indefatigably spike up to hundreds of Hz
C. Wichmann, T. Moser
core   +1 more source

Modes of Vesicle Retrieval at Ribbon Synapses, Calyx-Type Synapses, and Small Central Synapses [PDF]

The Journal of Neuroscience, 2007
### Introduction Endocytosis is essential for the maintenance of synaptic transmission because it recycles and thus prevents complete depletion of synaptic vesicles in the nerve terminal. The goal of understanding synaptic vesicle recycling mechanisms was launched in earnest in 1973 when ...
Ling-Gang, Wu, Timothy A, Ryan, Leon, Lagnado   +2 more
openaire   +2 more sources

Continuous and Transient Vesicle Cycling at a Ribbon Synapse [PDF]

The Journal of Neuroscience, 1998
Optical methods were used to study the Ca2+dependence of vesicle cycling in bipolar cells isolated from goldfish retinas. Uniformly raising the Ca2+concentration to between 0.8 and 20 μmproduced a continuous vesicle cycle of balanced exocytosis and endocytosis with a maximum rate equivalent to the turnover of the entire surface membrane of a terminal ...
N C, Rouze, E A, Schwartz
openaire   +2 more sources

Axonal synapses utilize multiple synaptic ribbons in the mammalian retina. [PDF]

PLoS ONE, 2012
In the mammalian retina, bipolar cells and ganglion cells which stratify in sublamina a of the inner plexiform layer (IPL) show OFF responses to light stimuli while those that stratify in sublamina b show ON responses.
Hong-Lim Kim, Ji Hyun Jeon, Tae-Hyung Koo, U-Young Lee, Eojin Jeong, Myung-Hoon Chun, Jung-Il Moon, Stephen C Massey, In-Beom Kim   +8 more
doaj   +1 more source

Remote Monitoring in Myasthenia Gravis: Exploring Symptom Variability

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Background Myasthenia gravis (MG) is a rare, autoimmune disorder characterized by fluctuating muscle weakness and potential life‐threatening crises. While continuous specialized care is essential, access barriers often delay timely interventions. To address this, we developed MyaLink, a telemedical platform for MG patients.
Maike Stein, Maximilian Mönch, Meret Herdick, Frauke Stascheit, Sarah Hoffmann, Hannah Preßler, Philipp Mergenthaler, Carla Dusemund, Paolo Doksani, Haoqi Sun, Pushpa Narayanaswami, Andreas Meisel, Lea Gerischer, Sophie Lehnerer   +13 more
wiley   +1 more source

Ribbon Synapses and Hearing Impairment in Mice After in utero Sevoflurane Exposure

Drug Design, Development and Therapy, 2020
Xia Yuan,1,* Hongjun Liu,1,* Yufeng Li,1 Wen Li,2 Huiqian Yu,3 Xia Shen1 1Department of Anesthesiology, Shanghai Eye, Ear, Nose, and Throat Hospital, Fudan University, Shanghai 200031, People’s Republic of China; 2Research Center, Shanghai Eye, Ear,
Yuan X, Liu H, Li Y, Li W, Yu H, Shen X
doaj  

Association of intracellular and synaptic organization in cochlear inner hair cells revealed by 3D electron microscopy [PDF]

, 2015
The ways in which cell architecture is modelled to meet cell function is a poorly understood facet of cell biology. To address this question, we have studied the cytoarchitecture of a cell with highly specialised organisation, the cochlear inner hair ...
Billups, Bullen, Csordas, Deerinck, Denk, Duncker, Esterberg, Francis, Harlow, Heidrych, Kantardzhieva, Khimich, Kujawa, Lenzi, Liberman, Liberman, Martínez-Menárguez, Mastronarde, Mastronarde, Matthews, Neef, Nouvian, Peng, Rowland, Safieddine, Schneider, Snellman, Spicer, Spicer, Steyger, Szule, Takumi, Tuffy, Vogl, Yin, Zelena   +35 more
core   +2 more sources

Multi‐Scale Interface Engineering of MXenes for Multifunctional Sensory Systems

Advanced Functional Materials, EarlyView.
MXenes, as two‐dimensional transition metal carbides and nitrides, demonstrate remarkable capabilities for multifunctional sensing applications. This review systematically examines multi‐scale interface engineering approaches that enhance sensing performance, enable diverse detection functionalities, and improve system‐level compatibility in MXene ...
Jiaying Liao, Sin‐Yi Pang, Jianhua Hao
wiley   +1 more source