Results 51 to 60 of about 16,795 (248)
Mechanism of High-Frequency Signaling at a Depressing Ribbon Synapse. [PDF]
Neuron, 2016 Ribbon synapses mediate continuous release in neurons that have graded voltage responses. While mammalian retinas can signal visual flicker at 80-100 Hz, the time constant, τ, for the refilling of a depleted vesicle release pool at cone photoreceptor ribbons is 0.7-1.1 s.
Grabner CP +3 more
europepmc +5 more sources
Energy required to pinch a DNA plectoneme [PDF]
, 2018 DNA supercoiling plays an important role on a biological point of view. One of its consequences at the supra-molecular level is the formation of DNA superhelices named plectonemes.
Barde, Céline +2 more
core +5 more sources
Regulation of Syntaxin3B-Mediated Membrane Fusion by T14, Munc18, and Complexin
Biomolecules, 2023 Retinal neurons that form ribbon-style synapses operate over a wide dynamic range, continuously relaying visual information to their downstream targets.
Rajkishor Nishad +4 more
doaj +1 more source
A genetically encoded reporter of synaptic activity in vivo [PDF]
, 2009 To image synaptic activity within neural circuits, we tethered the genetically encoded calcium indicator (GECI) GCaMP2 to synaptic vesicles by fusion to synaptophysin. The resulting reporter, SyGCaMP2, detected the electrical activity of neurons with two
B Granseth +35 more
core +1 more source
Epigallocatechin-3-gallate, a prototypic chemopreventative agent for protection against cisplatin-based ototoxicity [PDF]
, 2017 Cisplatin-induced ototoxicity is one of the major factors limiting cisplatin chemotherapy. Ototoxicity results from damage to outer hair cells (OHCs) and other regions of the cochlea.
Bhatta, Puspanjali +12 more
core +2 more sources
Nanomachinery Organizing Release at Neuronal and Ribbon Synapses [PDF]
International Journal of Molecular Sciences, 2019 A critical aim in neuroscience is to obtain a comprehensive view of how regulated neurotransmission is achieved. Our current understanding of synapses relies mainly on data from electrophysiological recordings, imaging, and molecular biology. Based on these methodologies, proteins involved in a synaptic vesicle (SV) formation, mobility, and fusion at ...
Wichmann, Carolin +3 more
openaire +4 more sources
eLifeSensory cells in the retina and inner ear rely on specialized ribbon synapses for neurotransmission. Disruption of these synapses is linked to visual and auditory dysfunction, but it is unclear how these unique synapses form.
Saman Hussain +4 more
doaj +1 more source
A Gata3–Mafb transcriptional network directs post-synaptic differentiation in synapses specialized for hearing [PDF]
, 2014 Information flow through neural circuits is determined by the nature of the synapses linking the subtypes of neurons. How neurons acquire features distinct to each synapse remains unknown.
Appler, Jessica M +5 more
core +1 more source
Ribbon synapses in zebrafish hair cells [PDF]
Hearing Research, 2015 The basic architecture and functionality of ribbon synapses of mechanosensitive hair cells are well conserved among vertebrates. Forward and reverse genetic methods in zebrafish (Danio rerio) have identified components that are critical for the development and function of ribbon synapses.
openaire +2 more sources
The diverse roles of ribbon synapses in sensory neurotransmission [PDF]
Nature Reviews Neuroscience, 2010 Sensory synapses of the visual and auditory systems must faithfully encode a wide dynamic range of graded signals, and must be capable of sustained transmitter release over long periods of time. Functionally and morphologically, these sensory synapses are unique: their active zones are specialized in several ways for sustained, rapid vesicle exocytosis,
Gary, Matthews, Paul, Fuchs
openaire +2 more sources