Current concepts in cochlear ribbon synapse formation [PDF]
Synapse, 2019 AbstractIn mammals, hair cells and spiral ganglion neurons (SGNs) in the cochlea together are sophisticated “sensorineural” structures that transduce auditory information from the outside world into the brain. Hair cells and SGNs are joined by glutamatergic ribbon‐type synapses composed of a molecular machinery rivaling in complexity the ...
Thomas M Coate +2 more
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Patterned pre-sensory spontaneous activity drives the structural refinement of developing cochlear ribbon synapses [PDF]
Frontiers in Synaptic NeuroscienceIntroductionIn the mammalian cochlea, hearing relies on highly specialized ribbon-type synapses between sensory inner hair cells (IHCs) and postsynaptic spiral ganglion neurons.
Victoria C. Halim +22 more
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Brevican “nets” voltage-gated calcium channels at the hair cell ribbon synapse [PDF]
BMC Biology, 2018 During hearing in mammals, “sensorineural” inner hair cells convert sound wave-generated mechanical input into electrical activity, resulting in glutamate release onto type I spiral ganglion neurons (SGNs) at specialized synapses known as “ribbon ...
Thomas M. Coate, Katherine Conant
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Role of the mouse retinal photoreceptor ribbon synapse in visual motion processing for optokinetic responses. [PDF]
PLoS ONE, 2015 The ribbon synapse is a specialized synaptic structure in the retinal outer plexiform layer where visual signals are transmitted from photoreceptors to the bipolar and horizontal cells.
Yuko Sugita +5 more
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Mammalian Cochlear Hair Cell Regeneration and Ribbon Synapse Reformation [PDF]
Neural Plasticity, 2016 Hair cells (HCs) are the sensory preceptor cells in the inner ear, which play an important role in hearing and balance. The HCs of organ of Corti are susceptible to noise, ototoxic drugs, and infections, thus resulting in permanent hearing loss.
Xiaoling Lu +3 more
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Ribbon synapse plasticity in the cochleae of Guinea pigs after noise-induced silent damage. [PDF]
PLoS ONE, 2013 Noise exposure at low levels or low doses can damage hair cell afferent ribbon synapses without causing permanent threshold shifts. In contrast to reports in the mouse cochleae, initial damage to ribbon synapses in the cochleae of guinea pigs is largely ...
Lijuan Shi +6 more
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Otoferlin acts as a Ca2+ sensor for vesicle fusion and vesicle pool replenishment at auditory hair cell ribbon synapses [PDF]
eLife, 2017 Hearing relies on rapid, temporally precise, and sustained neurotransmitter release at the ribbon synapses of sensory cells, the inner hair cells (IHCs).
Nicolas Michalski +19 more
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Neuroplastin 65 deficiency leads to the impairment of visual function through affecting ribbon synapse in retina of mice [PDF]
Frontiers in Cellular NeuroscienceNeuroplastin 65 (NP65) is a synapse-enriched glycoprotein in the central nervous system and is implicated in synaptic plasticity. In the present study, we found that NP65 knockout (NP65 KO) mice exhibit impaired visual function, including reductions in ...
Jiu-jiang Zeng +16 more
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Critical Role of the Presynaptic Protein CAST in Maintaining the Photoreceptor Ribbon Synapse Triad [PDF]
International Journal of Molecular Sciences, 2023 Akari Hagiwara +2 more
exaly +2 more sources
Role of intracellular calcium stores in hair cell ribbon synapse [PDF]
Frontiers in Cellular Neuroscience, 2014 .
Manuel eCastellano-Munoz +2 more
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