Results 131 to 140 of about 16,795 (248)
Clusterin accumulates in synapses in Alzheimer’s disease and is increased in Apolipoprotein E4 carriers [PDF]
, 2019 One of the major challenges in developing effective therapeutic strategies for Alzheimer's disease is understanding how genetic risk factors contribute to neurodegeneration.
Bayés +31 more
core +4 more sources
The local translation of KNa in dendritic projections of auditory neurons and the roles of KNa in the transition from hidden to overt hearing loss [PDF]
, 2019 Local and privileged expression of dendritic proteins allows segregation of distinct functions in a single neuron but may represent one of the underlying mechanisms for early and insidious presentation of sensory neuropathy.
Chiamvimonvat, Nipavan +8 more
core +1 more source
Ca2+ sensor synaptotagmin-1 mediates exocytosis in mammalian photoreceptors
eLife, 2019 To encode light-dependent changes in membrane potential, rod and cone photoreceptors utilize synaptic ribbons to sustain continuous exocytosis while making rapid, fine adjustments to release rate.
Justin J Grassmeyer +6 more
doaj +1 more source
GRF2 Is Crucial for Cone Photoreceptor Viability and Ribbon Synapse Formation in the Mouse Retina. [PDF]
Cells, 2023 Jimeno D +5 more
europepmc +1 more source
Glutamatergic retinal waves [PDF]
, 2016 Spontaneous activity patterns propagate through many parts of the developing nervous system and shape the wiring of emerging circuits. Prior to vision, waves of activity originating in the retina propagate through the lateral geniculate nucleus (LGN) of ...
Kerschensteiner, Daniel
core +4 more sources
New opportunities for bioscaffold‐enabled spinal cord injury repair
BMEMat, EarlyView.Schematic illustration of bioscaffolds for spinal cord injury repair. We summarize the effects of bioscaffold properties on SCI repair, highlight different types of bioscaffolds, various fabrication strategies, and in vivo transformations for the clinical development of SCI‐repairing bioscaffolds.
Xiaoqing Qi +11 more
wiley +1 more source
LifePhotoreceptors in the mammalian retina convert light signals into electrical and molecular signals through phototransduction and transfer the visual inputs to second-order neurons via specialized ribbon synapses.
Soo-Young Kim +3 more
doaj +1 more source
Primary neuronal degeneration in the guinea pig effects on spontaneous rate-type [PDF]
, 2013 Thesis (Ph. D.)--Harvard-MIT Program in Health Sciences and Technology.Cataloged from PDF version of thesis.Includes bibliographical references (p. 63-66).Acoustic overexposure can cause death of cochlear nerve fibers, even if elevations in cochlear ...
Furman, Adam C. (Adam Charles)
core
Mechanisms of sensorineural cell damage, death and survival in the cochlea. [PDF]
, 2015 The majority of acquired hearing loss, including presbycusis, is caused by irreversible damage to the sensorineural tissues of the cochlea. This article reviews the intracellular mechanisms that contribute to sensorineural damage in the cochlea, as well ...
Ryan, Allen F, Wong, Ann CY
core +1 more source
BMEMat, EarlyView.Abstract Hepatocellular carcinoma (HCC), ranking as the third leading cause of cancer‐related mortality globally, continues to pose significant therapeutic challenges. Here, we developed an innovative nanosystem, Phl@PT, based on Pt‐TiO2 nanoparticles for the co‐delivery of Phlorezin, presenting a novel approach for HCC treatment through sonodynamic ...
Kairui Liu +13 more
wiley +1 more source