Results 121 to 130 of about 16,795 (248)

Ribbon Synapses: Anchors away for a Fishy Tale [PDF]

Current Biology, 2005
Genetic screens in flies and worms have long been a powerful way of identifying proteins that regulate synaptic transmission. A recent study of ribbon synapses in the retina of zebrafish is an excellent example of how this approach can now be applied to a vertebrate species.
openaire   +2 more sources

Material‐Based Intelligence: Autonomous Adaptation and Embodied Computation in Physical Substrates

Advanced Intelligent Systems, EarlyView.
This perspective formulates a unifying framework for Material‐Based Intelligence (MBI), defining the physical requirements for materials to achieve embodied action, active memory and embodied information processing through intrinsic nonequilibrium dynamics. The design of intelligent materials often draws parallels with the complex adaptive behaviors of
Vladimir A. Baulin, Rudolf M. Füchslin, Achille Giacometti, Helmut Hauser, Marco Werner   +4 more
wiley   +1 more source

Sensory Transduction and Subjective Experience: Expression of eight genes in three senses suggests a radical model of consciousness [PDF]

, 2007
Recent research into whole genome mapping of the mouse brain has made possible direct investigation of the brain expression of unusual genes. A search of the Allen Brain Atlas database has provided genetic and neuro-anatomical evidence for widespread ...
Chris C. King
core   +1 more source

The transfer characteristics of hair cells encoding mechanical stimuli in the lateral line of zebrafish [PDF]

, 2019
Hair cells transmit mechanical information by converting deflection of the hair bundle into synaptic release of glutamate. We have investigated this process in the lateral line of larval zebrafish (male and female) to understand how mechanical stimuli ...
Lagnado, Leon, Pichler, Paul
core   +1 more source

Research progress on biomarkers of traumatic brain injury

Animal Models and Experimental Medicine, EarlyView.
Traumatic brain injury: From primary insult to secondary neuroinflammation and degeneration. Abstract Traumatic brain injury (TBI) is a common disorder of the nervous system and has become a leading cause of death and disability worldwide, imposing a substantial burden on patients and their social circles. Its main symptoms include dyskinesia, language
Xuting Shen, Si Cheng, Shuyi Chen, Mengyue Wang, Tangying Li, Weicheng Xu, Yifan Zhang, Ping Yuan, Lei Shi   +8 more
wiley   +1 more source

Amyloid Precursor-Like Protein 2 deletion-induced retinal synaptopathy related to congenital stationary night blindness: structural, functional and molecular characteristics. [PDF]

, 2015
Amyloid precursor protein knockout mice (APP-KO) have impaired differentiation of amacrine and horizontal cells. APP is part of a gene family and its paralogue amyloid precursor-like protein 2 (APLP2) has both shared as well as distinct expression ...
Abitbol, M., An, N., Arsenijevic, Y., Behar-Cohen, F., Borras, C., Cappai, R., Ciccotosto, G.D., Delaunay, K., Dinet, V., El Sanharawi, M., Jonet, L., Kostic, C., Mascarelli, F., Pirou, C., Ranchon-Cole, I., Savoldelli, M.   +15 more
core   +7 more sources

A novel mouse model simulating C5 palsy after cervical surgery

Animal Models and Experimental Medicine, EarlyView.
This study establishes a reliable mouse model of permanent C5 palsy (post‐laminectomy complication) via dorsal approach, selectively severing the C5 anterior nerve root while preserving the posterior root through partial C4 and C5 laminectomy. The model successfully replicates clinical C5P features—flaccid shoulder paralysis, electrophysiological ...
Chenpei Xu, Xianghe Wang, Mingjie Zhou, Chuxiang Chen, Tingzheng Jiang, Fei Wang, Kaixiang Yang, Hongli Wang, Su Jiang   +8 more
wiley   +1 more source

Quantitative and Qualitative Evaluation of Photoreceptor Synapses in Developing, Degenerating and Regenerating Retinas

Frontiers in Cellular Neuroscience, 2019
Quantitative and qualitative evaluation of synapses is crucial to understand neural connectivity. This is particularly relevant now, in view of the recent advances in regenerative biology and medicine.
Ryutaro Akiba, Ryutaro Akiba, Take Matsuyama, Hung-Ya Tu, Tomoyo Hashiguchi, Junki Sho, Shuichi Yamamoto, Masayo Takahashi, Michiko Mandai   +8 more
doaj   +1 more source

Cis-regulatory basis of sister cell type divergence in the vertebrate retina [PDF]

, 2019
Multicellular organisms evolved via repeated functional divergence of transcriptionally related sister cell types, but the mechanisms underlying sister cell type divergence are not well understood.
Corbo, Joseph C, Hughes, Andrew E.O., Lawrence, Karen A, Murphy, Daniel P, Myers, Connie A   +4 more
core   +3 more sources

Cancer therapy‐induced ototoxicity: Current challenges and emerging management strategies

Animal Models and Experimental Medicine, EarlyView.
This review comprehensively examines the key risk factors for cancer therapy‐induced ototoxicity, including cumulative drug dose, genetic susceptibility, and combined treatment regimens. It highlights current challenges in ototoxicity monitoring, such as insufficient timeliness and limited clinical adoption, and advocates for standardized auditory ...
Yuqi Huang, Baoying Xu, Xinru Chen, Yu Chen, Dehong Yu   +4 more
wiley   +1 more source