Results 141 to 150 of about 16,795 (248)

Light-dependent regulation of neurotransmitter release from rod photoreceptor ribbon synapses involves an interplay of Complexin 4 and Transducin with the SNARE complex

Frontiers in Molecular Neuroscience
Adaptation of photoreceptor sensitivity to varying light intensities is a fundamental requirement for retinal function and vision. Adaptive mechanisms in signal transduction are well described, but little is known about the mechanisms that adapt the ...
Uwe Thorsten Lux, Jutta Meyer, Olaf Jahn, Olaf Jahn, Adam Davison, Norbert Babai, Andreas Gießl, Anna Wartenberg, Heinrich Sticht, Nils Brose, Kerstin Reim, Johann Helmut Brandstätter   +11 more
doaj   +1 more source

EventFlow: Real‐time neuromorphic event‐driven classification of two‐phase boiling flow regimes

Droplet, EarlyView.
We present a real‐time flow regime classification framework that integrates neuromorphic event‐driven sensing with deep recurrent neural networks. Unlike traditional frame‐based approaches, our system captures sparse event streams from an event‐based camera, representing only the dynamic brightness changes at the individual pixel level.
Sanghyeon Chang, Srikar Arani, Nishant Sai Nuthalapati, Youngjoon Suh, Nicholas Choi, Siavash Khodakarami, Md Rakibul Hasan Roni, Nenad Miljkovic, Aparna Chandramowlishwaran, Yoonjin Won   +9 more
wiley   +1 more source

Early auto‐immune targeting of photoreceptor ribbon synapses in mouse models of multiple sclerosis

EMBO Molecular Medicine, 2018
Optic neuritis is one of the first manifestations of multiple sclerosis. Its pathogenesis is incompletely understood, but considered to be initiated by an auto‐immune response directed against myelin sheaths of the optic nerve.
Mayur Dembla, Ajay Kesharwani, Sivaraman Natarajan, Claudia Fecher‐Trost, Richard Fairless, Sarah K Williams, Veit Flockerzi, Ricarda Diem, Karin Schwarz, Frank Schmitz   +9 more
doaj   +1 more source

A Synaptic Mechanism for Temporal Filtering of Visual Signals [PDF]

, 2014
The visual system transmits information about fast and slow changes in light intensity through separate neural pathways. We used in vivo imaging to investigate how bipolar cells transmit these signals to the inner retina.
A Nikolaev, Anton Nikolaev, B Granseth, B Odermatt, B Roska, Benjamin Odermatt, BL Sabatini, D Bolinger, DA Protti, DB Kastner, E Dreosti, E Dreosti, Elena Dreosti, F Rieke, F Rieke, Federico Esposti, FS Werblin, G Neves, G Schwartz, GB Awatramani, GL Li, GW Schwartz, H Asari, H von Gersdorff, H von Gersdorff, H Wässle, I Mintz, J Burrone, J Burrone, J Burrone, J Robinson, J Vigh, JA Perge, JL Schnapf, L Lagnado, L Lagnado, Leon Lagnado, LF Abbott, M Coggins, M Holt, M Msghina, MB Manookin, MH Kim, MH Kim, MJ Palmer, MM Dorostkar, NL Allbritton, Q Gaudry, RH Masland, RH Masland, S Mennerick, S Saszik, SA Baccus, SA Baccus, SH DeVries, SH DeVries, SL Jackman, Stephen A. Baccus, T Baden, T Baden, T Baden, T Euler, T Euler, T Gollisch, T Hosoya, T Jarsky, TA Pologruto, Tom Baden, V Balasubramanian, V Beaumont, V Connaughton, W Taylor, WB Thoreson, WN Grimes, Y Ozuysal, YN Li   +75 more
core   +4 more sources

bacNeo: A Computational Toolkit for Identifying Bacteria‐Derived Neoantigens in Human Cancers

iMetaMed, EarlyView.
We present bacterial neoantigen (bacNeo), a multi‐omics‐based computational software to classify bacterial components (BACC), type bacteria‐bound HLA alleles (BACH), and prioritize bacterial peptides as neoantigens (BACP). Bacterial neoantigen potential is quantified by score for peptide antigenicity recognition & kinetics (SPARK), enabling ...
Yunzhe Wang, Li Yuan, Katie W. Gu, Xiangdong Cheng, Bo Wen, Zhao Zhang   +5 more
wiley   +1 more source

Respiratory Syncytial Virus Under the Lens of Structure: From Prefusion Stabilization to Next‐Generation Immunotherapies

iNew Medicine, EarlyView.
This illustration integrates key concepts covered in the review, including high‐risk populations, viral structure, host entry factors, the replication cycle, and licensed antibody‐based prevention strategies. ABSTRACT Respiratory syncytial virus (RSV) is a negative‐sense RNA virus belonging to the genus Orthopneumovirus within the family Pneumoviridae.
Zekai Cheng, Qianqian Wang, Jiachen Zhang, Sandra Chiu   +3 more
wiley   +1 more source

Cnr2 Is Important for Ribbon Synapse Maturation and Function in Hair Cells and Photoreceptors. [PDF]

Front Mol Neurosci, 2021
Colón-Cruz L, Rodriguez-Morales R, Santana-Cruz A, Cantres-Velez J, Torrado-Tapias A, Lin SJ, Yudowski G, Kensler R, Marie B, Burgess SM, Renaud O, Varshney GK, Behra M.   +12 more
europepmc   +1 more source

Alpha‐Synuclein Promotes Anterograde Vesicle Transport in Melanocytes and Melanoma Cells: A Pro‐Survival Function

Journal of the Chinese Chemical Society, EarlyView.
Model for how α‐syn modulates the positioning of endolysosomes in melanoma cells. (a) α‐syn tethers endolysosomes to the plasma membrane, a last step in anterograde transport. (b) Loss of α‐syn expression causes the loss of the tethering function, which leads to perinuclear vesicle clustering. Reproduced from the open access article.
Stephan N. Witt
wiley   +1 more source

Alterations in brain metabolites in rats with experimental periodontitis: A metabolomic approach

Journal of Periodontology, EarlyView.
Abstract Background Periodontitis (PD) is a chronic inflammatory disease with systemic effects. Emerging evidence suggests a link between periodontal inflammation and neurological changes, but the biochemical mechanisms in key brain regions, such as the hippocampus and amygdala, remain unclear.
Ramona Ramalho de Souza Pereira, Caíque Olegário Diniz e Magalhães, Elizabeth Luciana Marinho Miguel, Larissa Vieira Toledo, Débora Ribeiro Orlando, Alan Rodrigues Teixeira Machado, Bruno Del Bianco Borges, Luciano José Pereira, Marco Fabrício Dias‐Peixoto, Eric Francelino Andrade   +9 more
wiley   +1 more source

Proteomics of Nitrotyrosine: Integrating Mass Spectrometry and Immunodetection in Redox‐Driven Pathology

Mass Spectrometry Reviews, EarlyView.
ABSTRACT Nitrooxidative stress, driven by excess reactive nitrogen species like peroxynitrite, contributes to the pathogenesis of many chronic diseases. Among its molecular footprints, 3‐nitrotyrosine (3NT) has emerged as a biologically relevant marker of protein nitration.
Brîndușa Alina Petre
wiley   +1 more source