Results 91 to 100 of about 185,351 (165)

mRNA Decay Mediates Evolution and Biological Functions in Plant Gene Expression

Plant Biotechnology Journal, EarlyView.
ABSTRACT mRNA decay is a key post‐transcriptional regulatory mechanism that fine‐tunes plant development and stress adaptation through dynamic mRNA stability control, bridging fundamental biology and crop improvement. Current knowledge of mRNA decay mechanisms in plants, largely derived from Arabidopsis, is poorly generalisable across plant lineages ...
Haidan Wu, Dayin Lv, Yelin Huang, Yuchi He   +3 more
wiley   +1 more source

Ribo-seQC: comprehensive analysis of cytoplasmic and organellar ribosome profiling data [PDF]

, 2019
Summary: Ribosome profiling enables genome-wide analysis of translation with unprecedented resolution. We present Ribo-seQC, a versatile tool for the comprehensive analysis of Ribo-seq data, providing in-depth insights on data quality and translational ...
Ohler, U., Harnett, D., Calviello, L., Sydow, D.   +3 more
core   +1 more source

Neonate and Adult Human Platelet RNA-seq and Ribo-seq Data

, 2022
To compare the neonatal platelet transcriptome and translatome changes during development, RNA-seq and Ribo-seq were performed in platelet obtained from adult and cord blood (CB). For RNA-seq, there are 11 CB samples and 9 adult samples.
Liu, Z (via Mendeley Data), Liu, Zhaoyan
core   +1 more source

Transcriptional regulation of endothelial cell behavior during sprouting angiogenesis

Nature Communications, 2017
Angiogenesis is a complex process that requires coordinated changes in endothelial cell behavior. Here the authors use Ribo-tag and RNA-Seq to determine temporal profiles of transcriptional activity during postnatal retinal angiogenesis, identifying ...
Hyun-Woo Jeong, Benjamín Hernández-Rodríguez, JungMo Kim, Kee-Pyo Kim, Rocio Enriquez-Gasca, Juyong Yoon, Susanne Adams, Hans R. Schöler, Juan M. Vaquerizas, Ralf H. Adams   +9 more
doaj   +1 more source

Circular RNA circERBB2 Promotes Tumorigenesis via the miR‐1587/CBX2 Axis and Epigenetic Silencing of PTEN in Bladder Cancer Cells

MedComm – Oncology, Volume 5, Issue 4, December 2026.
circERBB2, originating from backsplicing of ERBB2 pre‑mRNA, is robustly upregulated in bladder cancer (BLCA) and acts as a miR‑1587 sponge to derepress chromobox 2 (CBX2). CBX2 subsequently recruits EZH2 to catalyze H3K27me3 deposition at the PTEN promoter, epigenetically silencing this tumor suppressor and unleashing the PI3K/AKT/mTOR cascade to drive
Xiang Pan, Xi Chen, Kailai Chen, Feng Pei, Li Zhong, Yunqi Li, Wenchao Shi, Jian Ma, Yakun Luo   +8 more
wiley   +1 more source

Genome-wide identification and differential analysis of translational initiation

Nature Communications, 2017
Translation initiation sequencing (TI-seq) has revealed unexpected diversity in protein isoforms. Here, Zhang et al. present Ribo-TISH, a computational toolkit that can detect and compare TIs across conditions and improve open reading frame prediction ...
Peng Zhang, Dandan He, Yi Xu, Jiakai Hou, Bih-Fang Pan, Yunfei Wang, Tao Liu, Christel M. Davis, Erik A. Ehli, Lin Tan, Feng Zhou, Jian Hu, Yonghao Yu, Xi Chen, Tuan M. Nguyen, Jeffrey M. Rosen, David H. Hawke, Zhe Ji, Yiwen Chen   +18 more
doaj   +1 more source

BOULE is Essential for the Dynamic Disassembly of Heat Shock Granules in Male Germ Cells

Advanced Science, Volume 13, Issue 61, 3 November 2026.
BOULE orchestrates stress granule disassembly in germ cells via a two‐pronged mechanism: it promotes G3BP1 ubiquitination by upregulating TRIM27, generating a signal for VCP/FAF2 recruitment, and it maintains G3BP1 and FAF2 protein levels. BOULE deficiency disrupts disassembly complex formation, leading to impaired heat shock granule clearance ...
Xin Li, Nana Zhang, Zexin Bian, Baobao Geng, Liyun Cao, Peipei Liu, Zengming Li, Yan Zhao, Jun Tan   +8 more
wiley   +1 more source

RiboMicrobe: An Integrated Translatome Atlas for Microorganism

Advanced Science
Ribosome profiling (Ribo‐seq) represents a significant advance in translatomics research. This technique enables the precise measurement of global and in vivo translation dynamics, the quantification of translation, and the identification of active ...
Yingshun Zhou, Jinjing Luo, Xiaoqiang Lang, Yuli Gan, Guoxian Liu, Yuling Cui, Fazhi Li, Weicong Zhu, Bing Chen, Yuanyuan Dong, Yinglin Wu, Yi Cao, Qi Liu   +12 more
doaj   +1 more source

Genome-wide assessment of differential translations with ribosome profiling data

Nature Communications, 2016
The global measurement of ribosome occupancy on mRNAs is commonly used as a proxy in estimating rates of protein synthesis. Here the authors describe Xtail, a computational approach that facilitates the extraction of accurate quantitative insight from ...
Zhengtao Xiao, Qin Zou, Yu Liu, Xuerui Yang   +3 more
doaj   +1 more source

Legume-rhizobia symbiosis: Translatome analysis [PDF]

Genetics and Molecular Biology
Leguminous plants can establish endosymbiotic relationships with nitrogen-fixing soil rhizobacteria. Bacterial infection and nodule organogenesis are two independent but highly coordinated genetic programs that are active during this interaction.
María Martha Sainz, Mariana Sotelo-Silveira, Carla V. Filippi, Sofía Zardo   +3 more
doaj   +1 more source