Results 91 to 100 of about 16,252 (205)
Protein kinase A regulates gene-specific translational adaptation in differentiating yeast [PDF]
, 2014 Cellular differentiation is driven by coordinately regulated changes in gene expression. Recent discoveries suggest that translation contributes as much as transcription to regulating protein abundance, but the role of translational regulation in ...
Gilbert, Wendy +3 more
core +1 more source
VIEW, EarlyView.PHF1 is a known epigenetic regulator involved in transcriptional silencing in cancer. In this study, we identified PHF1 as an oncogene that promotes PDAC progression and demonstrated that its inhibition induces ferroptosis. Mechanistically, PHF1 physically interacts with the FBL/NOP56/NOP58 snoRNP complex to enhance the IRES‐dependent translation of ...
Yujiao Xie +9 more
wiley +1 more source
Point-Wise Ribosome Translation Speed Prediction with Recurrent Neural Networks
MathematicsEscherichia coli is a benchmark organism, which has been deeply studied by the scientific community for decades, obtaining a vast amount of metabolic and genetic data.
Pietro Bongini +6 more
doaj +1 more source
Nature Communications, 2022 Viruses completely depend on the host translational machinery, but their genomes are often enriched in rare codons and therefore should be translated with poor efficiency. Here, Jungfleisch et al. apply Ribo-Seq and RNASeq to provide a global view on the
Jennifer Jungfleisch +6 more
doaj +1 more source
Ribo-seq guided design of enhanced protein secretion in Komagataella phaffii
Metabolic EngineeringAbstractThe production of recombinant proteins requires the precise coordination of various biological processes, including protein synthesis, folding, trafficking, and secretion. The overproduction of a heterologous protein can impose various bottlenecks on these networks.
Aida Tafrishi +3 more
openaire +2 more sources
The FEBS Journal, EarlyView.Small protein MtrR is a regulator of the Mtr methyltransferase complex in Methanosarcina mazei. It binds specifically to the MtrA subunit and modulates Mtr activity in response to hydrogen (H2) availability. Deleting mtrR impairs growth in the presence but not absence of H2, indicating its role in directing methyl transfer toward an energy‐conserving ...
Tim Habenicht +6 more
wiley +1 more source
Transcriptional regulation of endothelial cell behavior during sprouting angiogenesis
Nature Communications, 2017 Angiogenesis is a complex process that requires coordinated changes in endothelial cell behavior. Here the authors use Ribo-tag and RNA-Seq to determine temporal profiles of transcriptional activity during postnatal retinal angiogenesis, identifying ...
Hyun-Woo Jeong +9 more
doaj +1 more source
TITER: predicting translation initiation sites by deep learning. [PDF]
, 2017 MotivationTranslation initiation is a key step in the regulation of gene expression. In addition to the annotated translation initiation sites (TISs), the translation process may also start at multiple alternative TISs (including both AUG and non-AUG ...
Hu, Hailin +4 more
core +1 more source
The FEBS Journal, EarlyView.Fetal growth restriction is associated with placental metabolic adaptations. In small‐for‐gestational‐age placenta (SGA), cholesterol receptors and steroidogenic enzymes are upregulated, enhancing steroidogenesis. NAD salvage pathway is also increased to support NADP+/NADPH requirements.
Serena Xodo +4 more
wiley +1 more source
AnimalsThe yak (Bos grunniens) thrives under chronic hypoxia and cold on the Qinghai–Tibet Plateau, yet a cross-tissue view of post-transcriptional regulation in this species remains limited.
Zhenlin Zhu, Biao Li, Mingfeng Jiang
doaj +1 more source