Results 101 to 110 of about 16,252 (205)

Genome-wide identification and differential analysis of translational initiation

Nature Communications, 2017
Translation initiation sequencing (TI-seq) has revealed unexpected diversity in protein isoforms. Here, Zhang et al. present Ribo-TISH, a computational toolkit that can detect and compare TIs across conditions and improve open reading frame prediction ...
Peng Zhang, Dandan He, Yi Xu, Jiakai Hou, Bih-Fang Pan, Yunfei Wang, Tao Liu, Christel M. Davis, Erik A. Ehli, Lin Tan, Feng Zhou, Jian Hu, Yonghao Yu, Xi Chen, Tuan M. Nguyen, Jeffrey M. Rosen, David H. Hawke, Zhe Ji, Yiwen Chen   +18 more
doaj   +1 more source

Stem cell function and stress response are controlled by protein synthesis. [PDF]

, 2016
Whether protein synthesis and cellular stress response pathways interact to control stem cell function is currently unknown. Here we show that mouse skin stem cells synthesize less protein than their immediate progenitors in vivo, even when forced to ...
A Sobala, Abdulrahim Sajini, AL Means, B Schwanhäusser, CS Trempus, D Ruggero, DB Longley, DE Weinberg, DM Owens, DR Morris, E Fuchs, E Fuchs, F Tuorto, FJ Martinez, H Tang, HC Lin, Hinal Tanna, I Malanchi, J Gebetsberger, J Xing, Jelena Aleksic, JL Hintze, KA Spriggs, KK Youssef, KM Braun, L Abbasi-Moheb, L Madisen, M Egeblad, M Frye, M Frye, M Schaefer, M Schaefer, M Schober, M Sibilia, MA Khan, Martyna Popis, Michaela Frye, MV Gerashchenko, MV Plikus, N Atsumi, N Barker, Nikoletta Gkatza, NT Ingolia, NT Ingolia, NT Ingolia, NT Ingolia, P Ivanov, Patrick Lombard, PD Lu, PV Baranov, RA Signer, Roberto Bandiera, Rosana Cortés-Garrido, RS Joshi, RY Kao, S Blanco, S Blanco, S Hussain, S Hussain, S Hussain, S Hussain, S Müller-Röver, S Schleich, Sabine Dietmann, Sandra Blanco, SE Calvo, Shobbir Hussain, T Schneider-Poetsch, V Jaks, V Khoddami, X Zhang, Y Hirai   +71 more
core   +2 more sources

OsFKBP20‐1b stabilizes OsUPF1 and OsUPF2 to promote the degradation of aberrant mRNAs during dehydration stress

Journal of Integrative Plant Biology, EarlyView.
The rice protein OsFKBP20‐1b protects key RNA‐surveillance factors from breakdown, so they can better eliminate defective messages. This RNA quality‐control boost reduces errors and helps plants survive drought, revealing a link between RNA control and drought tolerance.
Haemyeong Jung, Hyun Ji Park, Seung Hee Jo, Ki‐Hong Jung, Choonkyun Jung, Hye Sun Cho   +5 more
wiley   +1 more source

RiboMicrobe: An Integrated Translatome Atlas for Microorganism

Advanced Science
Ribosome profiling (Ribo‐seq) represents a significant advance in translatomics research. This technique enables the precise measurement of global and in vivo translation dynamics, the quantification of translation, and the identification of active ...
Yingshun Zhou, Jinjing Luo, Xiaoqiang Lang, Yuli Gan, Guoxian Liu, Yuling Cui, Fazhi Li, Weicong Zhu, Bing Chen, Yuanyuan Dong, Yinglin Wu, Yi Cao, Qi Liu   +12 more
doaj   +1 more source

Genome-wide assessment of differential translations with ribosome profiling data

Nature Communications, 2016
The global measurement of ribosome occupancy on mRNAs is commonly used as a proxy in estimating rates of protein synthesis. Here the authors describe Xtail, a computational approach that facilitates the extraction of accurate quantitative insight from ...
Zhengtao Xiao, Qin Zou, Yu Liu, Xuerui Yang   +3 more
doaj   +1 more source

Legume-rhizobia symbiosis: Translatome analysis [PDF]

Genetics and Molecular Biology
Leguminous plants can establish endosymbiotic relationships with nitrogen-fixing soil rhizobacteria. Bacterial infection and nodule organogenesis are two independent but highly coordinated genetic programs that are active during this interaction.
María Martha Sainz, Mariana Sotelo-Silveira, Carla V. Filippi, Sofía Zardo   +3 more
doaj   +1 more source

The Gcn4 transcription factor reduces protein synthesis capacity and extends yeast lifespan [PDF]

, 2017
In Saccharomyces cerevisiae, deletion of large ribosomal subunit protein-encoding genes increases the replicative lifespan in a Gcn4-dependent manner. However, how Gcn4, a key transcriptional activator of amino acid biosynthesis genes, increases lifespan,
Aeschimann, Florian, Gross, Thomas, Guimaraes, Joao C., Leidel, Sebastian A., Mittal, Nitish, Nedialkova, Danny D., Schmidt, Alexander, Spang, Anne, Vina-Vilaseca, Arnau, Zavolan, Mihaela   +9 more
core   +2 more sources

Plant Peptides on the Rise: From Historical Insight to Future Applications

Plant Biotechnology Journal, EarlyView.
ABSTRACT Plant peptides constitute a rapidly expanding class of signalling molecules essential to plant physiology, mediating key processes such as development, stress adaptation, and immune responses. This review traces the history of plant peptide research, from the seminal discovery of systemin to the recent identification of non‐canonical peptides (
Shunxi Wang, Jinghua Zhang, Minghui Chen, Bokai Zhang, Huina Zhao, Liuji Wu   +5 more
wiley   +1 more source

Dynamic Landscapes of Long Noncoding RNAs During Early Root Development and Differentiation in Glycine max and Glycine soja

Plant, Cell &Environment, EarlyView.
ABSTRACT Soybean (Glycine max) is an important crop for its nutritional value. Its wild relative, Glycine soja, provides a valuable genetic resource for improving soybean productivity. Root development and differentiation are essential for soybean plants to take up water and nutrients, store energy and anchor themselves.
Qiaoxia Liang, Hafiz M. Rehman, Jizhou Zhang, Hon‐Ming Lam, Ting‐Fung Chan   +4 more
wiley   +1 more source

Translation initiation factor eIF4G1 preferentially binds yeast transcript leaders containing conserved oligo-uridine motifs [PDF]

, 2018
Translational control of gene expression plays essential roles in cellular stress responses and organismal development by enabling rapid, selective, and localized control of protein production.
Gilbert, Wendy, Rojas Duran, Maria Fernanda, Zinshteyn, Boris   +2 more
core   +1 more source