Results 101 to 110 of about 185,351 (165)

Identification of Prognostic Factors and Regulatory Pathways in Porto‐Sinusoidal Vascular Disorder

Liver International, Volume 46, Issue 11, November 2026.
ABSTRACT Background and Aims Porto‐sinusoidal vascular disorder (PSVD) is a rare liver condition characterized by specific histological features primarily affecting the hepatic sinusoidal and periportal vasculature, in the absence of cirrhosis. This study aimed to identify prognostic factors and regulatory pathways associated with PSVD by integrating ...
Subin Heo, Do Kyung Yoon, Soyeon Shin, Dami Youn, Youngeun Yoo, In Hye Song, Hyo Jeong Kang, Young‐In Yoon, Kyunggon Kim, Seung Soo Lee, Sung Won Chung, Jonggi Choi, Danbi Lee, Ju Hyun Shim, Kang Mo Kim, Young‐Suk Lim, Han Chu Lee, Mark Muthiah, Ho‐Su Lee, Won‐Mook Choi   +19 more
wiley   +1 more source

Summary of Ribo-seq and mRNA-seq libraries reported in this study.

Summary of Ribo-seq and mRNA-seq libraries reported in this study.
Mee-Ngan F. Yap (17827459), Dapeng Zhang (89211), Kathryn E. Shields (17827453), Yongjun Tan (553794), David Ranava (17827456)   +4 more
core   +1 more source

Regulation by the Transcriptional Regulator YdcI in E. coli and (p)ppGpp‐Dependent Activation of ydcI Expression

Molecular Microbiology, Volume 126, Issue 5, Page 503-518, November 2026.
YdcI, a LysR‐type transcription regulator in Escherichia coli, regulates loci like iraP and mqo. Its expression is induced by (p)ppGpp under stress conditions, and protein levels rise during mid‐exponential growth, connecting its role to stress response and metabolism control. ABSTRACT YdcI, a LysR‐type transcription regulator, has been associated with
Ria Basu Roy, Karin Schnetz
wiley   +1 more source

Comparative survey of the relative impact of mRNA features on local ribosome profiling read density

Nature Communications, 2016
Ribosome profiling data can suffer from uneven coverage which hampers estimation of elongation rates. Connor et al.present an enhanced data smoothing method for Ribo-seq data and highlight significant variability in sequence determinants of ribosome ...
Patrick B. F. O’Connor, Dmitry E. Andreev, Pavel V. Baranov   +2 more
doaj   +1 more source

Microprotein MP104 Promotes Malignant Progression of Colorectal Cancer Through Regulating Protein Translation

Advanced Science, Volume 13, Issue 56, 9 October 2026.
A previously unrecognized microprotein, MP104, encoded by ZEB1‐AS1, emerges as a critical driver of colorectal cancer progression. MP104 links ubiquitin‐mediated protein degradation with translational reprogramming via the UBE2O–AMPKα2–mTOR–EIF4B axis, revealing an unrecognized layer of oncogenic regulation.
Fang Chen, Miao Wang, Hongmei Yong, Jin Ding, Shiping Xu, Qirui Ge, Yan Wang, Lei Zhang, Qianqian Xiao, Benli Li, Li Lin, Sufang Chu, Qianqing Wang, Jin Bai, Pingfu Hou   +14 more
wiley   +1 more source

Ribo-seq guided design of enhanced protein secretion in Komagataella phaffii

Metabolic Engineering
Abstract The production of recombinant proteins requires the precise coordination of various biological processes, including protein synthesis, folding, trafficking, and secretion. The overproduction of a heterologous protein can impose various bottlenecks on these networks.
Aida Tafrishi, Troy Alva, Justin Chartron, Ian Wheeldon   +3 more
openaire   +2 more sources

A Novel tRNA Half mt‐5’‐tiRNA‐Tyr Promotes Colorectal Cancer Proliferation via Inducing HARS2 Succinylation

Advanced Science, Volume 13, Issue 57, 14 October 2026.
A mitochondria‐derived tRNA half, mt‐5’‐tiRNA‐Tyr, is upregulated in colorectal cancer tissues and plasma and promotes tumor proliferation. It binds HARS2 and promotes CPT1A‐associated HARS2 K91 succinylation, disrupts HARS2–mt‐tRNA‐His association, impairs mitochondrial translation, enhances succinate‐linked metabolic reprogramming, and shows promise ...
Xinliang Gu, Danping Zhu, Xinwei Liu, Shangshang Hu, Xincheng Yang, Junjie Nie, Tao Xu, Yuqin Pan, Mu Xu, Huiling Sun, Shukui Wang   +10 more
wiley   +1 more source

Extensive translation of small Open Reading Frames revealed by Poly-Ribo-Seq

eLife, 2014
Thousands of small Open Reading Frames (smORFs) with the potential to encode small peptides of fewer than 100 amino acids exist in our genomes. However, the number of smORFs actually translated, and their molecular and functional roles are still unclear.
Aspden, JL, Eyre-Walker, YC, Phillips, RJ, Amin, U, Mumtaz, MAS, Brocard, M, Couso, J-P   +6 more
openaire   +4 more sources

Transcriptome and translatome comparison of tissues from Arabidopsis thaliana

Scientific Data
Translation is one of the multiple complementary steps that orchestrates gene activity. In contrast to the straightforwardness of transcriptional surveys, genome-wide profiles of the translational landscape of plant cells remain technically challenging ...
Isabel Cristina Vélez-Bermúdez, Wen-Dar Lin, Shu-Jen Chou, Ai-Ping Chen, Wolfgang Schmidt   +4 more
doaj   +1 more source

uORF-Tools-Workflow for the determination of translation-regulatory upstream open reading frames.

PLoS ONE, 2019
Ribosome profiling (ribo-seq) provides a means to analyze active translation by determining ribosome occupancy in a transcriptome-wide manner. The vast majority of ribosome protected fragments (RPFs) resides within the protein-coding sequence of mRNAs ...
Anica Scholz, Florian Eggenhofer, Rick Gelhausen, Björn Grüning, Kathi Zarnack, Bernhard Brüne, Rolf Backofen, Tobias Schmid   +7 more
doaj   +1 more source