Results 111 to 120 of about 16,252 (205)

Comparative transcriptomics and ribo-seq: Looking at de novo gene emergence in Saccharomycotina [PDF]

, 2017
In de novo gene emergence, a segment of non-coding DNA undergoes a series of changes which enables transcription, potentially leading to a new protein that could eventually acquire a novel function. Due to their recent origins, young de novo genes have no homology with other genes.
Blevins, William, Albà, Mar, Carey, Lucas   +2 more
openaire   +1 more source

RXR Gamma Enables Oligodendrocyte Differentiation by Suppressing Sonic Hedgehog Signaling

Glia, Volume 74, Issue 6, June 2026.
Using pharmacogenetic approaches, Baldassarro et al. demonstrate that RXRγ suppresses the SHH signaling pathway in OPCs to ensure their efficient differentiation following T3 stimulation. Accordingly, Rxrg−/− OPCs displayed compromised differentiation which was normalized by the pharmacological inhibition of the hyperactive SHH pathway.
Vito Antonio Baldassarro, Quentin Brassart, Valérie Fraulob, Laura Calzà, Wojciech Krezel   +4 more
wiley   +1 more source

uORF-Tools-Workflow for the determination of translation-regulatory upstream open reading frames.

PLoS ONE, 2019
Ribosome profiling (ribo-seq) provides a means to analyze active translation by determining ribosome occupancy in a transcriptome-wide manner. The vast majority of ribosome protected fragments (RPFs) resides within the protein-coding sequence of mRNAs ...
Anica Scholz, Florian Eggenhofer, Rick Gelhausen, Björn Grüning, Kathi Zarnack, Bernhard Brüne, Rolf Backofen, Tobias Schmid   +7 more
doaj   +1 more source

TORCing to secretory senescence [PDF]

, 2015
Cellular senescence is often accompanied by the production of secreted proteins that mediate the diverse effects of senescence on the tissue microenvironment. The mammalian target of rapamycin (mTOR), a master regulator of protein synthesis, is now shown
Narita, Masashi, Tomimatsu, Kosuke
core   +1 more source

Sphingosine‐1‐Phosphate Promotes FOS Activation in Osteosarcoma Under Tumor Acidosis

Acta Physiologica, Volume 242, Issue 6, June 2026.
ABSTRACT Aim The tumor microenvironment in solid tumors is characterized by extracellular acidosis, which promotes cancer aggressiveness. In osteosarcoma, the most common primary bone cancer, a highly acidic tumor microenvironment is associated with metastasis and poor prognosis, partly due to metabolic rewiring, including changes in lipid pathways ...
Nicolò Bozzini, Margherita Cortini, Alberto Righi, Agamemnon E. Grigoriadis, Michael Dack, Elizabeta Ilieva, Federica Torricelli, Veronica Manicardi, Nicola Baldini, Sofia Avnet   +9 more
wiley   +1 more source

The use of duplex-specific nuclease in ribosome profiling and a user-friendly software package for Ribo-seq data analysis. [PDF]

, 2015
Ribosome profiling is a technique that permits genome-wide, quantitative analysis of translation and has found broad application in recent years. Here we describe a modified profiling protocol and software package designed to benefit more broadly the ...
Baulcombe, David C, Brierley, Ian, Chung, Betty Y, Firth, Andrew E, Hardcastle, Thomas J, Irigoyen, Nerea, Jones, Joshua D   +6 more
core   +2 more sources

Analysis of the Matrix Metalloproteinases Family Profile in Gastric Cancer Suggests Key Matrix Metalloproteinases for Tumor Development and Their Clinical Impact

Molecular Carcinogenesis, Volume 65, Issue 5, Page 577-588, May 2026.
ABSTRACT Gastric cancer (GC) is the fifth most common type worldwide, representing a public health problem. Among the genes related to this tumorigenesis, the family of matrix metalloproteinases (MMPs), essential regulators of the extracellular matrix (ECM), stand out for their involvement in the development and progression of GC.
Aline Costa Bastos, André Salim Khayat, Emanuele Raimunda Louzada Moraes, Ágatha Tereza Miranda Tavares, Ronald Matheus da Silva Mourão, Fabiano Cordeiro Moreira, Samir Mansour Moraes Casseb, Samia Demachki, Geraldo Ishak, Williams Fernandes Barra, Rommel Mario Rodríguez Burbano, Paulo Pimentel de Assumpção   +11 more
wiley   +1 more source

Transcriptome and translatome comparison of tissues from Arabidopsis thaliana

Scientific Data
Translation is one of the multiple complementary steps that orchestrates gene activity. In contrast to the straightforwardness of transcriptional surveys, genome-wide profiles of the translational landscape of plant cells remain technically challenging ...
Isabel Cristina Vélez-Bermúdez, Wen-Dar Lin, Shu-Jen Chou, Ai-Ping Chen, Wolfgang Schmidt   +4 more
doaj   +1 more source

SpectroGene: A Tool for Proteogenomic Annotations Using Top-Down Spectra [PDF]

, 2015
In the past decade, proteogenomics has emerged as a valuable technique that contributes to the state-of-the-art in genome annotation; however, previous proteogenomic studies were limited to bottom-up mass spectrometry and did not take advantage of top ...
Kolmogorov, Mikhail, Liu, Xiaowen, Pevzner, Pavel A.   +2 more
core   +1 more source

Deciphering the biosynthetic pathways of lichen acids

New Phytologist, Volume 250, Issue 3, Page 1784-1799, May 2026.
Summary Depsides and depsidones are polyketide‐derived lichen acids widely distributed in lichen thalli, yet the biosynthetic gene clusters (BGCs) responsible for their production remain poorly understood. To address this gap, we investigated the diversity and evolutionary relationships of polyketide BGCs in lichens.
Wonyong Kim, Tânia Keiko Shishido, Huong T. Pham, Kyo Bin Kang, Rundong Liu, Matti Wahlsten, Jérôme Collemare, Hyun Park, Soon‐Ok Oh, Hyung‐Ho Ha, Hangun Kim, Jae‐Seoun Hur   +11 more
wiley   +1 more source