Results 81 to 90 of about 16,252 (205)

A golden age for working with public proteomics data [PDF]

, 2017
Data sharing in mass spectrometry (MS)-based proteomics is becoming a common scientific practice, as is now common in the case of other, more mature 'omics' disciplines like genomics and transcriptomics.
Martens, Lennart, Vizcaíno, Juan Antonio   +1 more
core   +1 more source

Antibiotic Remodeling of the Gut Microbiota Impairs Host Resistance to Secondary Infection

iMetaMed, EarlyView.
Gut microbial dynamics induced by four antibiotics, revealed distinct taxonomic and functional shifts. Vancomycin‐perturbed bacteriomes were proven to promote pathogen resistance to antibiotic treatment. Metronidazole‐treated mice showed pronounced Salmonella translocation to hepatic tissue, and altered Enterococcus avium populations modulated host ...
Miaoyu Li, Ying Chen, Xi Chen, Weili Lu, Jie Liao, Jiaqi Wang, Qiwei Liu, Yanzi Chang, Zeping Xu, Yanye Tu, Yang Zhou, Jing Xue, Binbin Wang, Kang Chen, Keyun Cheng, Chunlai Zeng, Hong Li, Qing Shen   +17 more
wiley   +1 more source

Efficient Detection of the Alternative Spliced Human Proteome Using Translatome Sequencing

Frontiers in Molecular Biosciences, 2022
Alternative splicing (AS) isoforms create numerous proteoforms, expanding the complexity of the genome. Highly similar sequences, incomplete reference databases and the insufficient sequence coverage of mass spectrometry limit the identification of AS ...
Chun Wu, Xiaolong Lu, Shaohua Lu, Shaohua Lu, Hongwei Wang, Dehua Li, Jing Zhao, Jingjie Jin, Zhenghua Sun, Qing-Yu He, Yang Chen, Gong Zhang   +11 more
doaj   +1 more source

Musashi proteins are post-transcriptional regulators of the epithelial-luminal cell state [PDF]

, 2014
The conserved Musashi (Msi) family of RNA binding proteins are expressed in stem/progenitor and cancer cells, but generally absent from differentiated cells, consistent with a role in cell state regulation.
Beard, Ber, Busch, Cancer Genome Atlas Network, Chakrabarti, Chigurupati, Colitti, Das, Dickson, dos Santos, Feng, Foubert, Han, Hirata, Imai, Ingolia, Jangi, Katz, Kawahara, Kayahara, Kharas, Kim, Knight, Lambert, Lee, Leong, Lobry, MacNicol, Mani, Mortazavi, Muto, Nakamura, Okabe, Okano, Okano, Park, Parker, Polyak, Ray, Reinke, Sakakibara, Sethi, Shapiro, Takahashi, Timmerman, Venables, Verhaak, Wang, Wang, Warzecha, Yamamoto, Yu, Zavadil   +52 more
core   +3 more sources

CMAISE: Establishing the Longitudinal Multi‐Omics Cohort for Sepsis Precision Medicine

Med Research, EarlyView.
ABSTRACT Sepsis remains a leading cause of mortality worldwide due to its profound biological heterogeneity. While multi‐omics approaches offer promise for precision medicine, existing datasets often lack longitudinal granularity or comprehensive clinical integration. We present the Chinese Multi‐omics Advances In Sepsis (CMAISE) cohort, a prospective,
Jie Yang, Suibi Yang, Jiajun Cai, Songzan Qian, Shuping Song, Jun Guo, Yang Wang, Jinyan Xing, Bo Zhang, Zhihao Wang, Shengze Wu, Xinhao Jin, Bowen Tan, Dongdong Yang, Yao Yan, Haoran Chen, Changlin Sun, Kang Zou, Yuxin Leng, Jingye Pan, Tianlong Zhang, Yiming Shao, Lina Xian, Hongjun Kang, Zhen Wang, Ruilan Wang, Nan Wang, Lvyin Yan, Kun Cheng, Songqiao Liu, Lin Chen, Caibao Hu, Fuhong Su, Qian Gao, Yi Yang, Zhongheng Zhang, On behalf of Chinese Multi‐omics Advances In Sepsis (CMAISE) Consortium   +36 more
wiley   +1 more source

Integrated Transcriptomic and Translatomic Inquiry of the Role of Betaine on Lipid Metabolic Dysregulation Induced by a High-Fat Diet

Frontiers in Nutrition, 2021
An excessive high-fat/energy diet is a major cause of obesity and linked complications, such as non-alcoholic fatty liver disease (NAFLD). Betaine has been shown to effectively improve hepatic lipid metabolism.
Tengda Huang, Lin Yu, Hongyuan Pan, Zeqiang Ma, Tian Wu, Lifang Zhang, Kang Liu, Qi Qi, Weiwei Miao, Ziyi Song, Haojie Zhang, Lei Zhou, Yixing Li   +12 more
doaj   +1 more source

Quick change: post-transcriptional regulation in Pseudomonas [PDF]

, 2017
Pseudomonas species have evolved dynamic and intricate regulatory networks to fine-tune gene expression, with complex regulation occurring at every stage in the processing of genetic information.
Afonyushkin, Agalarov, Andrade, Arce-Rodriguez, Baker, Barquist, Berghoff, Bhagirath, Boudry, Brencic, Brencic, Broder, Bubunenko, Cech, Chambers, Chambonnier, Chatterjee, Coggan, Desnoyers, Duss, Fang, Fernandez, Fields, Gao, Goodman, Goodman, Heurlier, Holmqvist, Holmqvist, Hsu, Ingolia, Irie, Jacob G. Malone, Jean-Pierre, Jorgensen, Jorgensen, Kang, Kong, Lapouge, Lin, Link, Little, Lu, Lucia Grenga, Maki, Melamed, Meyer, Mikulecky, Miller, Moll, Moller, Morita, Moscoso, Mulcahy, Nesterchuk, Petrova, Reimmann, Richard H. Little, Schubert, Schulmeyer, Sittka A, Sobrero, Sonnleitner, Sonnleitner, Sonnleitner E, Takeuchi, Thomason, Unwin, Valentin-Hansen, Van Assche, Ventre, Vogel, Wang, Wang, Wei, Zhang, Zhang   +76 more
core   +1 more source

Quinolone tolerance in Escherichia coli due to defects in the adenosine ribonucleotides de novo biosynthesis pathway

mLife, EarlyView.
Abstract Central carbon metabolism is thought to link reactive oxygen species (ROS) with antibiotic‐mediated bacterial death. During enrichment screening of Escherichia coli with the first‐generation quinolone oxolinic acid, unstable antibiotic‐tolerant mutants containing deficiencies in purB were obtained.
Weiwei Zhu, Yuejuan Nong, Jie Su, Jingwen Yang, Lina Ma, Yunxin Xue, Dai Wang, Jianjun Niu, Karl Drlica, Xilin Zhao   +9 more
wiley   +1 more source

New peptides under the s(ORF)ace of the genome [PDF]

, 2015
Hundreds of previously unidentified functional small peptides could exist in most genomes, but these sequences have been generally overlooked. The discovery of genes encoding small peptides with important functions in different organisms, has ignited the
Couso, Juan P, Magny, Emile G, Pueyo-Marques, Jose L   +2 more
core   +1 more source

Whole‐transcriptome sequencing analyses identified exosomal circular RNAs in the plasma of pancreatic cancer patients as novel blood‐based biomarkers of disease

VIEW, EarlyView.
Pancreatic cancer (PaCa) has a poor prognosis, with low resection rates and high relapse rates, highlighting the urgent need for novel diagnostic biomarkers. Here, we performed whole‐transcriptome sequencing of plasma‐derived exosomes from PaCa patients and identified several differentially expressed circular RNAs (circRNAs).
Xiaomeng He, Yang Di, Lixiang Sun, Zhirong Wu, Mengting Luo, Xin Zhang, Huaqin Sun, Wanli Xu, Wenchuan Wu, Boheng Zhang, Jin Wang   +10 more
wiley   +1 more source