Results 141 to 150 of about 185,351 (165)

RAFTER: a releasing factor tethered RNA editing system for quantifying mRNA translation. [PDF]

Life Sci Alliance
Sun Z, Dong P, Yan H, Wen X, Li Y, Jiang F, Fang L, Wang X, Chen W.   +8 more
europepmc   +1 more source

Hepatic translational rewiring in insulin deficiency identifies Reg3α as an insulin-independent glucoregulatory factor.

Endocrinology
D S Teixeira P, Vincent SM, Meurs R, Ursino G, Zahoran S, Lucibello G, M Authiat M, Gavin AC, Ramadori G, Coppari R.   +9 more
europepmc   +1 more source

Beyond Read-Counts: Ribo-Seq Data Analysis to Understand the Functions of the Transcriptome

Trends in Genetics, 2017
By mapping the positions of millions of translating ribosomes in the cell, ribosome profiling (Ribo-seq) has established its role as a powerful tool to study gene expression. Several laboratories have introduced modifications to the experimental protocol
Uwe Ohler, Lorenzo Calviello
exaly   +4 more sources

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A Ribo-Seq Method to Study Genome-Wide Translational Regulation in Plants

Methods in Molecular Biology, 2022
Protein production from mRNA is one of the fundamental molecular processes in a cell. Accurate genome-wide information on the levels of translation and ribosome distribution on mRNA can be gathered by carrying out ribosome footprinting, aka Ribo-seq.
Jose Alonso, Anna N. Stepanova
exaly   +3 more sources

Scikit-Ribo Enables Accurate Estimation and Robust Modeling of Translation Dynamics at Codon Resolution

Cell Systems, 2018
Summary Ribosome profiling (Ribo-seq) is a powerful technique for measuring protein translation; however, sampling errors and biological biases are prevalent and poorly understood.
Yi-Fei Huang, Adam C. Siepel, Han Fang
exaly   +2 more sources

RiboSimR: A Tool for Simulation and Power Analysis of Ribo-seq Data

2020
RNA-seq and Ribo-seq are widespread quantitative methods for assessing transcription and translation. They can be used to detect differential expression, differential translation, and differential translation efficiency between conditions. The statistical power to detect differential genes is affected by multiple factors, such as the number of ...
Patrick Perkins, Anna N. Stepanova, José M. Alonso, Steffen Heber   +3 more
openaire   +1 more source

Poly-A Tailing and Adaptor Ligation Methods for Ribo-Seq Library Construction

2021
Ribosome profiling is a powerful technique that enables researchers to monitor translational events across the transcriptome. It provides a snapshot of ribosome positions and density across the transcriptome at a sub-codon resolution. Here we describe the whole procedure of profiling ribosome footprints in mammalian cells.
Jingfan, Qiu, Shu-Bing, Qian
openaire   +2 more sources

Single-cell Ribo-seq reveals cell cycle-dependent translational pausing

Nature, 2021
Single-cell sequencing methods have enabled in-depth analysis of the diversity of cell types and cell states in a wide range of organisms. These tools focus predominantly on sequencing the genomes1, epigenomes2 and transcriptomes3 of single cells. However, despite recent progress in detecting proteins by mass spectrometry with single-cell resolution4 ...
Michael VanInsberghe, Jeroen van den Berg, Amanda Andersson-Rolf, Hans Clevers, Alexander van Oudenaarden   +4 more
openaire   +2 more sources