Results 1 to 10 of about 145,501 (289)

Origin, Diversity, and Multiple Roles of Enzymes with Metallo-β-Lactamase Fold from Different Organisms

Cells, 2023
β-lactamase enzymes have generated significant interest due to their ability to confer resistance to the most commonly used family of antibiotics in human medicine.
Seydina M. Diene, Pierre Pontarotti, Saïd Azza, Nicholas Armstrong, Lucile Pinault, Eric Chabrière, Philippe Colson, Jean-Marc Rolain, Didier Raoult   +8 more
doaj   +1 more source

Sialic Acid-Binding Lectin from Bullfrog Eggs Exhibits an Anti-Tumor Effect Against Breast Cancer Cells Including Triple-Negative Phenotype Cells

Molecules, 2018
Sialic acid-binding lectin from Rana catesbeiana eggs (cSBL) is a multifunctional protein that has lectin and ribonuclease activity. In this study, the anti-tumor activities of cSBL were assessed using a panel of breast cancer cell lines. cSBL suppressed
Takeo Tatsuta, Shoko Sato, Toshiyuki Sato, Shigeki Sugawara, Tsuneyoshi Suzuki, Akiyoshi Hara, Masahiro Hosono   +6 more
doaj   +1 more source

Structural and functional characterization of Cas2 of CRISPR-Cas subtype I-C lacking the CRISPR component

Frontiers in Molecular Biosciences, 2022
The genome of pathogenic Leptospira interrogans serovars (Copenhageni and Lai) are predicted to have CRISPR-Cas of subtypes I-B and I-C. Cas2, one of the core Cas proteins, has a crucial role in adaptive defense against foreign nucleic acids.
Vineet Anand, Harshini Sheeja Prabhakaran, Prerana Gogoi, Shankar Prasad Kanaujia, Manish Kumar   +4 more
doaj   +1 more source

A general approach to high-yield biosynthesis of chimeric RNAs bearing various types of functional small RNAs for broad applications. [PDF]

, 2015
RNA research and therapy relies primarily on synthetic RNAs. We employed recombinant RNA technology toward large-scale production of pre-miRNA agents in bacteria, but found the majority of target RNAs were not or negligibly expressed. We thus developed a
Chen, Qiu-Xia, Urayama, Shiro, Wang, Wei-Peng, Yu, Ai-Ming, Zeng, Su   +4 more
core   +2 more sources

RNASET2 Deficiency Induces Hepatocellular Carcinoma Metastasis through Cholesterol‐Triggered MET Activation

Advanced Science
Metastasis remains a significant challenge in the treatment of hepatocellular carcinoma (HCC). The role of ribonuclease T2 (RNASET2) in HCC is still uncertain, although it has been reported to have contradictory effects on some cancers.
Yanquan Xu, Yu Chen, Jiangang Zhang, Jingchun Wang, Shuai Yang, Huakan Zhao, Lei Wu, Juan Lei, Yu Zhou, Jin Peng, Lu Jiang, Qian Chen, Rong Xin, Jianyun Zhou, Yongsheng Li   +14 more
doaj   +1 more source

Genetic diversity of human RNase 8

BMC Genomics, 2012
Background Ribonuclease 8 is a member of the RNase A family of secretory ribonucleases; orthologs of this gene have been found only in primate genomes. RNase 8 is a divergent paralog of RNase 7, which is lysine-enriched, highly conserved, has prominent ...
Chan Calvin C, Moser Jennifer M, Dyer Kimberly D, Percopo Caroline M, Rosenberg Helene F   +4 more
doaj   +1 more source

The Secreted Ribonuclease SRE1 Contributes to Setosphaeria turcica Virulence and Activates Plant Immunity

Frontiers in Microbiology, 2022
During the plant infection process, pathogens can secrete several effectors. Some of the effectors are well-known for their roles in regulating plant immunity and promoting successful pathogen colonization.
Shidao He, Yufei Huang, Yanqiu Sun, Bo Liu, Suna Wang, Yuanhu Xuan, Zenggui Gao   +6 more
doaj   +1 more source

Cationic poly(amidoamine) promotes cytosolic delivery of bovine RNase A in melanoma cells, while maintaining its cellular toxicity [PDF]

, 2015
Ribonucleases are known to cleave ribonucleic acids, inducing cell death. RNase A, a member of the ribonuclease family, generally displayed poor in vitro activity. This has been attributed to factors such as low intracellular delivery.
Akinc, Almeida, Berisio, Cafaro, Chao, Cohen, Coué, Coué, De Lorenzo, Di Donato, Ding, Dubois, Ellis, Ercole, Ferruti, Foglia, Futami, Futami, Futami, Hattori, Hunter, Iversen, Ivinova, Karayianni, Larsericsdotter, Lavignac, Lavignac, Lavignac, Ledoux, Lee, Leich, Leland, Lienqueo, Liu, Lo, Mahn, Matousek, Mattison, Nicholson, Parhamifar, Parhamifar, Pattrick, Peng, Pfeil, Pouckova, Pouckova, Richardson, Romanini, Sasisanker, Saxena, Sedlak, Seyrek, Smith, Tribet, van de Weert, Vottariello, Wang, Wilson, Xia, Yeo, Zhang   +60 more
core   +1 more source

Plus-strand RNA viruses hijack Musashi homolog 1 to shield viral RNA from cytoplasmic ribonuclease degradation

Journal of Virology
A successful strategy employed by RNA viruses to achieve replication is to evade host cell RNase degradation. However, the mechanisms through which plus-strand RNA viruses effectively shield viral RNA from cellular ribonuclease degradation remain unclear.
Defang Zhou, Menglu Xu, Qingjie Liu, Ruixue Xin, Gege Cui, Longying Ding, Xiaoyang Liu, Xinyue Zhang, Tianxing Yan, Jing Zhou, Shuhai He, Liangyu Yang, Bin Xiang, Ziqiang Cheng   +13 more
doaj   +1 more source

Novel Ribonuclease Activity Differs between Fibrillarins from Arabidopsis thaliana

Frontiers in Plant Science, 2017
Fibrillarin is one of the most important nucleolar proteins that have been shown as essential for life. Fibrillarin localizes primarily at the periphery between fibrillar center and dense fibrillar component as well as in Cajal bodies.
Ulises Rodriguez-Corona, Alejandro Pereira-Santana, Margarita Sobol, Luis C. Rodriguez-Zapata, Pavel Hozak, Enrique Castano   +5 more
doaj   +1 more source