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Leveraging RIBOTAC technology: Fluorescent RNase L probes for live-cell imaging and function analysis [PDF]
HeliyonRNA-targeting small molecules, particularly RIBOnuclease TArgeting Chimeras (RIBOTACs), represent a powerful and promising therapeutic approach by selectively degrading RNAs through ribonuclease (RNase) recruitment.
Elias Khaskia, Raphael I. Benhamou
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Circular Dichroism of Ribonuclease A, Ribonuclease S, and Some Fragments
Journal of Biological Chemistry, 1968 Abstract The circular dichroism of ribonuclease A, ribonuclease S, S-protein, S-peptide, and ribonuclease S' has been measured in aqueous solutions in the 215 to 300 mµ region. The circular dichroism spectra of ribonuclease A and ribonuclease S are virtually identical; that of ribonuclease S' is similar but lacks a positive peak at 240 mµ.
Elizabeth R. Simons, Elkan Blout
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Agronomy, 2023 T2 ribonucleases are endoribonucleases that are found in every organism and that carry out important biological functions. In plants, T2 ribonucleases are organized into multi-gene families, and each member is thought to have a specific function. In this
Mercedes Diaz-Baena +3 more
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Agronomy, 2021 Germination and seedling development are crucial phases in a plant’s life cycle with economical and agronomical implications. The RNA quality in seeds is linked to seed viability, being an important agronomic trait since this leads to a loss in ...
Mercedes Diaz-Baena +4 more
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Structural Insights into the Dimeric Form of Bacillus subtilis RNase Y Using NMR and AlphaFold
Biomolecules, 2022 RNase Y is a crucial component of genetic translation, acting as the key enzyme initiating mRNA decay in many Gram-positive bacteria. The N-terminal domain of Bacillus subtilis RNase Y (Nter-BsRNaseY) is thought to interact with various protein partners ...
Nelly Morellet +4 more
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Streptomyces RNases – Function and impact on antibiotic synthesis
Frontiers in Microbiology, 2023 Streptomyces are soil dwelling bacteria that are notable for their ability to sporulate and to produce antibiotics and other secondary metabolites. Antibiotic biosynthesis is controlled by a variety of complex regulatory networks, involving activators ...
George H. Jones
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Microorganisms, 2021 Controlled RNA degradation is a crucial process in bacterial cell biology for maintaining proper transcriptome homeostasis and adaptation to changing environments.
Truc Thanh Luong +11 more
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The reaction of ribonuclease inhibitor with modified ribonucleases [PDF]
Biochemical Journal, 1966 1. The effect of chemical modification of ribonuclease on its reaction with ribonuclease inhibitor has been studied. 2. Removal of free amino groups from the enzyme with nitrous acid or by acetylation did not affect the reaction. Some changes altered the stoicheiometry of the reaction and ribonuclease S was found to be inhibited linearly by increasing ...
Jay S. Roth, Deirdre Hurley
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Frontiers in Microbiology, 2022 Angiogenin 4 bearing ribonuclease activity is an endogenous antimicrobial protein expressed in small and large intestine. However, the crucial amino acid residues responsible for the antibacterial activity of Ang4 and its impact on gut microbiota remain ...
Mst. Farzana Sultana +7 more
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Microbiology Spectrum, 2023 Toxin-antitoxin (TA) systems are widespread among prokaryotes and can play an important role in the maintenance of genetic elements and pathogen virulence.
Xudong Wang +9 more
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