Results 111 to 120 of about 139,231 (236)
Small nuclear RNA transcription and ribonucleoprotein assembly in early Xenopus development. [PDF]
The Journal of cell biology, 1983 The Xenopus egg and embryo, throughout the transcriptionally inactive early cleavage period, were found to contain a store of approximately 8 X 10(8) molecules of the small nuclear RNA (snRNA) U1, sufficient for 4,000-8,000 nuclei. In addition, when transcription is activated at the twelfth cleavage (4,000 cell-stage), the snRNAs U1, U2, U4, U5, and U6
Forbes, DJ, Kornberg, TB, Kirschner, MW
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SNUPN deficiency causes a recessive muscular dystrophy due to RNA mis-splicing and ECM dysregulation
Nature CommunicationsSNURPORTIN-1, encoded by SNUPN, plays a central role in the nuclear import of spliceosomal small nuclear ribonucleoproteins. However, its physiological function remains unexplored.
Marwan Nashabat +56 more
doaj +1 more source
Annexin, a Protein for All Seasons: From Calcium Dependent Membrane Metabolism to RNA Recognition
BioEssays, EarlyView.Annexins are an important protein family traditionally well known to bind to phospholipids and to interact with various proteins in a calcium dependent way. More recently, it has been established that a feature common to the family is also to bind to RNA having a role in translation. In bies70019 article, Vedeler et al.
Anni Vedeler +2 more
wiley +1 more source
Proceedings of the National Academy of Sciences of the United States of America, 1984 Antibodies directed against small nuclear ribonucleoprotein ( snRNP ) particles are found in the Sm and RNP autoimmune sera from numerous patients with systemic lupus erythematosus (SLE) and mixed connective tissue disease (MCTD).
D. Fisher +4 more
semanticscholar +1 more source
Modulation of alternative splicing by expression of small nuclear ribonucleoprotein polypeptide N [PDF]
The FEBS Journal, 2014 Alternative splicing of pre‐mRNA, catalyzed by small nuclear ribonucleoproteins (snRNPs), plays an important role in proteome complexity and the modulation of cellular functions. snRNP polypeptide N (SmN), is tissue‐specifically expressed, where it replaces snRNP polypeptide B (SmB)/B′ in the Sm core assembly of snRNPs. Recent studies have demonstrated
Yu-Shan Lin +7 more
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Biology Open, 2019 The most common types of modification in human rRNA are pseudouridylation and 2′-O ribose methylation. These modifications are performed by small nucleolar ribonucleoproteins (snoRNPs) which contain a guide RNA (snoRNA) that base pairs at specific sites ...
Marilyn F. Burke +3 more
doaj +1 more source
Scientific Reports, 2021 Eukaryotic cells can expand their coding ability by using their splicing machinery, spliceosome, to process precursor mRNA (pre-mRNA) into mature messenger RNA.
Tao Fan +10 more
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Trimethylguanosine nucleoside inhibits cross-linking between snurportin 1 and m3G-capped U1 snRNA [PDF]
, 2015 Macromolecular nuclear import is an energy-and signal-dependent process. The best characterized type of nuclear import consists of proteins carrying the classical NLS that is mediated by the heterodimeric receptor importin α/β. Spliceosomal snRNPs U1, U2,
Aviñó, Anna +4 more
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Biotechnology and Bioengineering, EarlyView.A novel strategy for nuclear gene delivery in microalgae using a cell‐penetrating peptide (CPP) and nuclear localization signal (NLS) is described. The authors developed a triple nanocomplex of CPP, plasmid DNA, and SV40 NLS to enhance nuclear delivery in Chlamydomonas reinhardtii.
Eun Jeong Sim +10 more
wiley +1 more source
Aggregation Properties of the Small Nuclear Ribonucleoprotein U1-70K in Alzheimer Disease [PDF]
Journal of Biological Chemistry, 2014 Recent evidence indicates that U1-70K and other U1 small nuclear ribonucleoproteins are Sarkosyl-insoluble and associate with Tau neurofibrillary tangles selectively in Alzheimer disease (AD). Currently, the mechanisms underlying the conversion of soluble nuclear U1 small nuclear ribonucleoproteins into insoluble cytoplasmic aggregates remain elusive ...
Chadwick M. Hales +12 more
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