ABSTRACT Microalgae are increasingly recognised as powerful platforms for the sustainable production of lipids and terpenoids, with expanding applications in the food, fuel and biomanufacturing industries. In this updated review, we consolidate and critically assess the most recent advances in synthetic biology and metabolic engineering of key ...
Ty Shitanaka +6 more
wiley +1 more source
Multidimensional regulatory roles and therapeutic applications of SRSF7 in cancer. [PDF]
Li Y +5 more
europepmc +1 more source
Protoplast‐Based Functional Genomics and Genome Editing: Progress, Challenges and Applications
ABSTRACT Protoplast‐based systems provide a powerful and versatile platform for exploring how plants sense and respond to their environment. By enabling the direct delivery of proteins, DNA, and RNA into plant cells after cell wall removal, this approach facilitates precise molecular dissection of signaling, stress adaptation, and gene regulation ...
Jo‐Wei Allison Hsieh +8 more
wiley +1 more source
Unnatural Amino Acid and Emerging Chemistry Approaches to Map RNA–Protein Interactions
This review highlights emerging chemistries for mapping RNA–protein interactions, including genetically encoded unnatural amino acids, novel photocrosslinkers, and non‐photoactivatable crosslinking systems. We compare their mechanisms, reactivity and applications, outlining how these next‐generation tools enable higher‐resolution, site‐specific ...
Eryn Lundrigan +3 more
wiley +2 more sources
The CoREST Complex Regulates Alternative Splicing by the Transcriptional Regulation of RNA Processing Genes in Melanoma Cells. [PDF]
Khan AA +5 more
europepmc +1 more source
Evolution of H5N1 Cross‐Species Transmission: Adaptive Mutations Driving Avian‐to‐Human Infection
This review synthesizes current knowledge on the molecular mechanisms underpinning H5N1's host adaptation, focusing on key mutations in viral proteins. Critical mutations are discussed in detail, highlighting their roles in altering receptor specificity, promoting antiviral resistance, and expanding viral tropism. The review underscores the urgent need
Wenxin Man +7 more
wiley +1 more source
A working model for cytoplasmic assembly of H/ACA snoRNPs. [PDF]
Angrisani A, Furia M.
europepmc +1 more source
Human Cyclophilins—An Emerging Class of Drug Targets
ABSTRACT Cyclophilins are a family of enzymes with peptidyl‐prolyl isomerase activity found in all cells of all organisms. To date, 17 cyclophilin isoforms have been identified in the human body, participating in diverse biological processes. Consequently, cyclophilins have emerged as promising targets for drug development to address a wide array of ...
Katarina Jurkova +3 more
wiley +1 more source
Cajal's organization of neuronal nucleus revisited. [PDF]
Lafarga M +4 more
europepmc +1 more source
RNA‐Binding Proteins and Ferroptosis in Cancer: Mechanism and Therapeutic Implications
Ferroptosis critically influences cancer cell fate and represents a promising therapeutic strategy. Emerging evidence identifies RNA‐binding proteins (RBPs) as key post‐transcriptional regulators of ferroptosis. The figure summarizes ferroptosis‐related RBPs across cancers: blue RBPs act as tumor suppressors by promoting ferroptosis, whereas red RBPs ...
Linlin Chang +6 more
wiley +1 more source

