Results 171 to 180 of about 139,231 (236)

Converting Blastocrithidia Nonstop, a Trypanosomatid With Non‐Canonical Genetic Code, Into a Genetically‐Tractable Model

Molecular Microbiology, EarlyView.
Blastocrithidia represents a very small group of species, in which all 3 stop codons are reassigned to encode amino acids with only one of them serving a dual role of a sense and a stop codon simultaneously. Here we demonstrated for the first time that B. nonstop can be genetically modified.
Arnau Galan, Natalya Kraeva, Kristína Záhonová, Anzhelika Butenko, Alexei Yu Kostygov, Zdeněk Paris, Jiří Pergner, Claretta Bianchi, Fadel Fakih, Andreu Saura, Julius Lukeš, Vyacheslav Yurchenko   +11 more
wiley   +1 more source

PRPF mutations are associated with generalized defects in spliceosome formation and pre-mRNA splicing in patients with retinitis pigmentosa [PDF]

, 2017
Proteins PRPF31, PRPF3 and PRPF8 (RP-PRPFs) are ubiquitously expressed components of the spliceosome, a macromolecular complex that processes nearly all pre-mRNAs.
Abou Elela, Sherif, Berson, Eliot L., Chabot, Benoit, Klinck, Roscoe, Ransijn, Adriana, Rivolta, Carlo, Tanackovic, Goranka, Thibault, Philippe   +7 more
core  

At‐RS31 orchestrates hierarchical cross‐regulation of splicing factors and integrates alternative splicing with TOR‐ABA pathways

New Phytologist, EarlyView.
Summary Alternative splicing is essential for plants, enabling a single gene to produce multiple transcript variants to boost functional diversity and fine‐tune responses to environmental and developmental cues. Arabidopsis thaliana At‐RS31, a plant‐specific splicing factor in the Serine/Arginine‐rich (SR) protein family, responds to light and the ...
Tino Köster, Peter Venhuizen, Martin Lewinski, Ezequiel Petrillo, Yamile Marquez, Armin Fuchs, Debashish Ray, Barbara A. Nimeth, Stefan Riegler, Sophie Franzmeier, Florencia S. Rodríguez, Federico E. Aballay, Rocío S. Tognacca, Hong Zheng, Timothy Hughes, Quaid Morris, Andrea Barta, Dorothee Staiger, Maria Kalyna   +18 more
wiley   +1 more source

Alternative Splicing Regulation in Metabolic Disorders

Obesity Reviews, EarlyView.
ABSTRACT Alternative splicing (AS) is a fundamental mechanism for enhancing transcriptome diversity and regulating gene expression, crucial for various cellular processes and the development of complex traits. This review examines the role of AS in metabolic disorders, including obesity, weight loss, dyslipidemias, and metabolic syndrome.
Dorota Kaminska
wiley   +1 more source

Recent advances in proteomic workflows to interrogate the SUMOylome in plants

New Phytologist, Volume 247, Issue 1, Page 90-96, July 2025.
Summary Protein posttranslational modifications (PTMs) are vital for regulating protein functions. SUMOylation, a PTM essential for plant survival, involves attaching a Small Ubiquitin‐like MOdifier (SUMO) to lysine residues of target proteins. SUMOylation influences stress tolerance, cell proliferation, protein stability, and gene expression.
Kishor D. Ingole, Elizaveta Alekseeva, Kathryn S. Lilley, Ari Sadanandom   +3 more
wiley   +1 more source

Functional Biomaterials Derived from Protein Liquid–Liquid Phase Separation and Liquid‐to‐Solid Transition

Advanced Materials, Volume 37, Issue 22, June 5, 2025.
Protein can undergo liquid–liquid phase separation and liquid‐to‐solid transition to form liquid condensates and solid aggregates. These phase transitions can be influenced by post‐translational modifications, mutations, and various environmental factors.
Tianchen Li, Dea Ilhamsyah, Benedict Tai, Yi Shen   +3 more
wiley   +1 more source

ZNHIT3 Regulates Translation to Ensure Cell Lineage Differentiation in Mouse Preimplantation Development

Advanced Science, Volume 12, Issue 21, June 5, 2025.
Box C/D snoRNP complex regulates protein translation. This study identifies ZNHIT3 as a key component of the complex and ensures normal protein expression, including transcription factors orchestrating cell fate commitment, during early mouse embryogenesis.
Guanghui Yang, Qiliang Xin, Jurrien Dean
wiley   +1 more source

Both conserved signals on mammalian histone pre-mRNAs associate with small nuclear ribonucleoproteins during 3' end formation in vitro

Molecular and Cellular Biology, 1987
K. Mowry, J. Steitz
semanticscholar   +1 more source

Efficient targeted DNA editing and replacement in Chlamydomonas reinhardtii using Cpf1 ribonucleoproteins and single-stranded DNA [PDF]

, 2017
Ferenczi, Aron, Molnar, Attila, Pyott, Douglas Euan, Xipnitou, Andromachi   +3 more
core   +1 more source

Targeting PTBP3‐Mediated Alternative Splicing of COX11 Induces Cuproptosis for Inhibiting Gastric Cancer Peritoneal Metastasis

Advanced Science, Volume 12, Issue 21, June 5, 2025.
The splicing factor PTBP3 promotes COX11 exon skipping, allowing gastric cancer organoids to evade cuproptosis. Antisense oligonucleotide drugs targeting PTBP3‐mediated COX11 alternative splicing, in combination with copper ionophores, promote cuproptosis in organoids, thereby providing a therapeutic approach for gastric cancer peritoneal metastasis ...
Yajing Zhou, Chao Dong, Xiaochun Shen, Pengbo Wang, Tao Chen, Weikang Li, Xiaotong Sun, Peiyuan Li, Chengxiang Xu, Kaipeng Duan, Dongbao Li, Jin Zhou   +11 more
wiley   +1 more source