Results 211 to 220 of about 25,036 (270)

Floral stage optimization and immune evasion enhance Agrobacterium‐mediated genome editing in Arabidopsis

New Phytologist, Volume 249, Issue 4, Page 2125-2139, February 2026.
Summary Agrobacterium‐mediated transformation by floral inoculation (AMT‐FI) enables genetic engineering without tissue culture. It is widely used in the model plant Arabidopsis thaliana, yet its efficiency and broader applicability remain limited. Here, we used a dual‐reporter system (RUBY and hygromycin resistance) to identify key floral stages and ...
Mao‐Sen Liu, Teng‐Kuei Huang, Yi‐Chieh Wang, Si‐Chong Wang, Chih‐Hang Wu, Chih‐Horng Kuo, Erh‐Min Lai   +6 more
wiley   +1 more source

An elevated level of the mRNA exporter Mex67-Mtr2 in nuclear mRNPs impairs nuclear mRNA export. [PDF]

Nucleic Acids Res
Stefanyshena N, Sträßer K.
europepmc   +1 more source

Defining the Intestinal eCBome and Oxylipin Signaling Systems in a TDP‐43 Mouse Model of Frontotemporal Dementia

The FASEB Journal, Volume 40, Issue 2, 31 January 2026.
TDP‐43 overexpressing mice, a genetic model of frontotemporal dementia, exhibit dramatic changes in their small intestinal endocannabinoidome members, in terms of both altered concentrations of lipid mediators and expression of some of their receptors (Cnr1, Gpr119, Gpr55, Pparg) and metabolic enzymes (Napepld, Faah). Also, the levels of some oxylipins
Hayatte‐Dounia Mir, Giada Giorgini, Irene Santos‐García, Elizabeth Dumais, Carmen Rodríguez‐Cueto, Eva de Lago, Cristoforo Silvestri, Nicolas Flamand, Javier Fernández‐Ruiz, Vincenzo Di Marzo   +9 more
wiley   +1 more source

RNA modifications and Prp24 coordinate Lsm2-8 binding dynamics during S. cerevisiae U6 snRNP assembly. [PDF]

J Biol Chem
Liu Y, Nomura Y, Butcher SE, Hoskins AA.
europepmc   +1 more source

Nuclear transport of uracil-rich small nuclear ribonucleoprotein particles

, 1995
openaire   +1 more source

hnRNPU Safeguards Oocyte Development and Female Fertility via Regulation of Alternative Splicing

The FASEB Journal, Volume 40, Issue 2, 31 January 2026.
Heterogeneous nuclear ribonucleoprotein U (hnRNPU) is essential for oocyte development and female fertility. Oocyte‐specific deletion of Hnrnpu leads to follicular arrest, impaired meiotic maturation, mitochondrial dysfunction, and infertility.
Jinmei Li, Bei Chen, Yujiao Wen, Yanqing Wu, Kuan Liu, Jingshou Chen, Shuangqi Wang, Shenglei Feng, Juan Dong   +8 more
wiley   +1 more source

Identification and functional characterization of splicing factors implicated in mantle cell lymphoma aggressiveness. [PDF]

Sci Rep
Yosudjai J, Poohadsuan J, Samart P, Rodboon N, Issaragrisil S, Luanpitpong S.   +5 more
europepmc   +1 more source

Mining Potential Therapeutic Targets for T Cell Exhaustion in Osteoarthritis by Integrating Mendelian Randomization and Single‐Cell Sequencing

The FASEB Journal, Volume 40, Issue 2, 31 January 2026.
This study conducted an integrated analysis using multi‐source data, with specific data sources including the GEO database (encompassing datasets GSE55235, GSE55457, and GSE152805), literature‐mined gene sets, and the IEU OpenGWAS database (dataset ebi‐a‐GCST005814).
Jiahong Li, Yi Ye, Yan Zhang, Wei Fang, Fei Lan, Qian Yang, Lun Wan, Jiang Hu, Chengwei Xiao, Kun Zhang   +9 more
wiley   +1 more source

Diabetic keratopathy and nuclear proteins (Review). [PDF]

Mol Med Rep
Xu H, Jiang ZL, Wang Y, Hou X, Dong W, Chen Y, Zhang Q, Ji X, Ji S, Dang Y.   +9 more
europepmc   +1 more source

Gezielte Modulation des spliceosomalen Proteins USP39 durch allosterische Liganden und PROTAC‐induzierte Degradation

Angewandte Chemie, Volume 138, Issue 5, 28 January 2026.
Proteolysis‐targeting Chimeras (PROTACs) ermöglichen die gezielte Degradation bislang als „undruggable“ geltende Proteine über das zelluläre Ubiquitin–Proteasom‐System. In dieser Studie identifizieren Schäfer et al. thiazolbasierte niedermolekulare Liganden, die allosterisch an die Zinkfinger‐Domäne der Ubiquitin‐spezifischen Protease 39 (USP39) binden
Daniel Schäfer, Cristian Prieto‐Garcia, Jianhui Wang, Marcel Heinz, Vigor Matkovic, Pavel Kielkowski, Sebastian Hasselbeck, Varun Jayeshkumar Shah, Stefan Knapp, Gerhard Hummer, Ivan Dikic, Xinlai Cheng   +11 more
wiley   +1 more source