Results 221 to 230 of about 25,036 (270)

Sni445 recruits box C/D snoRNPs snR4 and snR45 to guide ribosomal RNA acetylation by Kre33. [PDF]

Nucleic Acids Res
Hafner J, Zierler I, Hamze H, Favre S, Thoms M, Kunowska N, Rimser S, Albert B, Caetano T, Aguirrebengoa M, Beckmann R, Stelzl U, Kressler D, Henras AK, Pertschy B.   +14 more
europepmc   +1 more source

Targeting the Spliceosomal Protein USP39 Through Allosteric Ligands and PROTAC‐Induced Degradation

Angewandte Chemie International Edition, Volume 65, Issue 5, 28 January 2026.
Proteolysis‐targeting chimeras (PROTACs) enable degradation of proteins previously considered undruggable by harnessing the cellular ubiquitin–proteasome system. In this study, Schäfer et al. identify thiazole‐based small molecules that allosterically bind the zinc finger domain of ubiquitin‐specific protease 39 (USP39), a non‐enzymatic scaffold ...
Daniel Schäfer, Cristian Prieto‐Garcia, Jianhui Wang, Marcel Heinz, Vigor Matkovic, Pavel Kielkowski, Sebastian Hasselbeck, Varun Jayeshkumar Shah, Stefan Knapp, Gerhard Hummer, Ivan Dikic, Xinlai Cheng   +11 more
wiley   +1 more source

Generation and ophthalmological characterization of oculocutaneous albinism type 1 pig models by selection-free genome editing. [PDF]

Sci Rep
Oh D, Seok C, Park HW, Park S, Lee J, Choi H, Jawad A, Ham J, Jang H, Lee SC, Oh BC, Moon C, Park KH, Hyun SH, Kim D.   +14 more
europepmc   +1 more source

Likely Pathogenic/Pathogenic Variants in the Spliceosome Complex Genes SNRNP200, SF3B1, SF3B2, and SF3B4 Implicated in Nonsyndromic Orofacial Cleft. [PDF]

Hum Mutat
Ranji P, Pairet E, Helaers R, Brouillard P, Bayet B, Gerdom A, Revencu N, Vikkula M.   +7 more
europepmc   +1 more source

Role of p62 nuclear condensates in regulating ubiquitin-mediated proteasomal degradation. [PDF]

Essays Biochem
Lulu-Shimron C, Ciechanover A, Cohen-Kaplan V.   +2 more
europepmc   +1 more source

Nascent RNA Folding and RNP Assembly Revealed by Single-molecule Microscopy. [PDF]

J Mol Biol
Bustamante A, Carrocci TJ, Nicholson DA, Rodgers ML.   +3 more
europepmc   +1 more source

Diverse roles of stress-responsive RNP granules in oogenesis and infertility. [PDF]

Biol Reprod
Glineburg MR, Nguyen C.
europepmc   +1 more source

Dysregulation of SRSF11 in Cancer: Mechanistic Insights and Biomarker Potential for Diagnosis and Therapy. [PDF]

J Cancer
Jun Y, Shanshan L, Jingwen X, Yu H, Jianlong X, Qingfeng S.   +5 more
europepmc   +1 more source

Foot-and-mouth disease virus 3C protease as virulence determinant plays multiple roles in cleaving viral polyprotein and host factors. [PDF]

Virulence
Zhou H, Wang M, Xin Z, Li Z, Wang Q, Li Y, Liu F.   +6 more
europepmc   +1 more source

Prevalence of Antinuclear Antibodies in Patients With Coronary Artery Disease: A Scoping Review. [PDF]

Cureus
Antony M, Thymalil C, Nagy S, Amini K, Kesselman MM.   +4 more
europepmc   +1 more source