Results 81 to 90 of about 38,830 (350)

Influenza virus genome reaches the plasma membrane via a modified endoplasmic reticulum and Rab11-dependent vesicles

Nature Communications, 2017
Transport of neo-synthesized influenza A virus viral ribonucleoproteins (vRNPs) from the nucleus to the plasma membrane involves Rab 11 but the mechanism is unclear.
Isabel Fernández de Castro Martin, Guillaume Fournier, Martin Sachse, Javier Pizarro-Cerda, Cristina Risco, Nadia Naffakh   +5 more
doaj   +1 more source

Assembly and budding of influenza virus. [PDF]

, 2004
Influenza viruses are causative agents of an acute febrile respiratory disease called influenza (commonly known as "flu") and belong to the Orthomyxoviridae family.
Barman, Subrata, Hui, Eric Ka-Wai, Nayak, Debi P   +2 more
core  

Small Extracellular Vesicles Orchestrate Cisplatin‐Induced Ototoxicity: Potential Biomarker and Targets Discovery

Advanced Science, EarlyView.
Cisplatin causes reactive oxygen species accumulation, leading to apoptosis and inflammation in cochlear hair cells. Small extracellular vesicles primarily derived from the damaged hair cells likely contribute to cisplatin‐induced ototoxicity, carrying a variety of microRNAs and proteins.
Jingru Ai, Shasha Zhang, Mingchen Dai, Pei Jiang, Jingyuan Huang, Hairong Xiao, Yanqin Lin, Xujun Tang, Wei Tong, Jun He, Qiuyue Mao, Yintao Wang, Zixuan Ye, Tian Wang, Renjie Chai   +14 more
wiley   +1 more source

New insights into trypanosomatid U5 small nuclear ribonucleoproteins

Memorias do Instituto Oswaldo Cruz, 2011
Several protozoan parasites exist in the Trypanosomatidae family, including various agents of human diseases. Multiple lines of evidence suggest that important differences are present between the translational and mRNA processing (trans splicing) systems
Marco Túlio A da Silva, Daniela L Ambrósio, Caroline C Trevelin, Tatiana F Watanabe, Helen J Laure, Lewis J Greene, José C Rosa, Sandro R Valentini, Regina MB Cicarelli   +8 more
doaj   +1 more source

Enhanced NK-92 Cytotoxicity by CRISPR Genome Engineering Using Cas9 Ribonucleoproteins

Frontiers in Immunology, 2020
Natural killer (NK) cells are an attractive cell-type for adoptive immunotherapy, but challenges in preparation of therapeutic primary NK cells restrict patient accessibility to NK cell immunotherapy. NK-92 is a well-characterized human NK cell line that
Rih-Sheng Huang, Hsin-An Shih, Hsin-An Shih, Min-Chi Lai, Min-Chi Lai, Yao-Jen Chang, Steven Lin, Steven Lin   +7 more
doaj   +1 more source

RNA-Seq of the nucleolus reveals abundant SNORD44-derived small RNAs. [PDF]

PLoS ONE, 2014
Small non-coding RNAs represent RNA species that are not translated to proteins, but which have diverse and broad functional activities in physiological and pathophysiological states. The knowledge of these small RNAs is rapidly expanding in part through
Baoyan Bai, Srinivasan Yegnasubramanian, Sarah J Wheelan, Marikki Laiho   +3 more
doaj   +1 more source

SUMOylation is a Translatable Target in Hypoxic MNPs Regulating Retinal Vasculopathy

Advanced Science, EarlyView.
During ischemic retinopathy/retinal vasculopathy, UBC9‐mediated SUMOylation in retinal macrophages enhances their pro‐angiogenic capacity via hypoxia‐induced SUMOylation of FUS at K327/K502. This modification suppresses FUS binding to the Vegfa mRNA 3’UTR, stabilizing transcripts and facilitating VEGFA production. Targeting UBC9 inhibition can serve as
Zheng Zhong, Guangyu Liang, Huimin Yu, Jiaqi Li, Ruohong Wang, Xiaohong Ma, Ziqing Zhou, Yin Zhao, Fei Sun, Xufang Sun   +9 more
wiley   +1 more source

CRISPR/Cas9‐mediated genome editing reveals seven testis‐enriched transmembrane glycoproteins dispensable for male fertility in mice

Andrology, EarlyView., 2023
Abstract Background Mammalian fertilization is mediated by multiple sperm acrosomal proteins, many of which are testis‐enriched transmembrane glycoproteins expressed during spermiogenesis (e.g., Izumo sperm‐egg fusion 1, Sperm acrosome associated 6, and Transmembrane protein 95).
Yo Ogawa, Yonggang Lu, Daiji Kiyozumi, Hsin‐Yi Chang, Masahito Ikawa   +4 more
wiley   +1 more source

Genome editing in primary cells and in vivo using viral-derived Nanoblades loaded with Cas9-sgRNA ribonucleoproteins

Nature Communications, 2019
A current challenge in genome editing is delivering Cas9 and sgRNA into target cells. Here the authors engineer a delivery system based on murine leukemia virus-like particles loaded with Cas9-sgRNA ribonucleoproteins to induce efficient genome editing ...
Philippe E. Mangeot, Valérie Risson, Floriane Fusil, Aline Marnef, Emilie Laurent, Juliana Blin, Virginie Mournetas, Emmanuelle Massouridès, Thibault J. M. Sohier, Antoine Corbin, Fabien Aubé, Marie Teixeira, Christian Pinset, Laurent Schaeffer, Gaëlle Legube, François-Loïc Cosset, Els Verhoeyen, Théophile Ohlmann, Emiliano P. Ricci   +18 more
doaj   +1 more source

The Structures, Functions, and Evolution of Sm-like Archaeal Proteins (SmAPs) [PDF]

arXiv, 2016
Sm proteins were discovered nearly 20 years ago as a group of small antigenic proteins ($\approx$ 90-120 residues). Since then, an extensive amount of biochemical and genetic data have illuminated the crucial roles of these proteins in forming ribonucleoprotein (RNP) complexes that are used in RNA processing, e.g., spliceosomal removal of introns from ...
arxiv