Results 41 to 50 of about 4,163 (154)
BMC Molecular and Cell Biology, 2021 Background Thymidine kinase 1 (TK1) plays a key role in the synthesis of deoxythymidine triphosphate (dTTP) and is thus important for DNA replication and cell proliferation.
Liya Wang +5 more
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Journal of Extracellular Vesicles, Volume 15, Issue 3, March 2026.Workflow of the work. (1) Human muscle biopsies were collected, and the human muscle precursor cells (hMPC) were isolated, followed by co‐culture with human monocytes (THP‐1). In parallel, human muscles were decellularised to obtain an extracellular matrix (ECM) free of cells. ECM were recellularised by injecting hMPC and THP1 into the matrix.
Agner Henrique Dorigo Hochuli +20 more
wiley +1 more source
From Ribonucleoside 5'-Aldehydes to Ribonucleoside 5'-C-phosphonates as Building Blocks for Oligonucleotide Synthesis [PDF]
Nucleic Acids Symposium Series, 2008 The synthetic approach towards selected monomers of ribonucleosidyl-5'-C-phosphonates I compatible with the phosphotriester condensation method is presented, together with the surprising and unexpected effect of TEA.3HF on the phosphonate moiety observed upon removal of the O-silyl protecting groups.
Maqdalena, Petrová +3 more
openaire +2 more sources
Prebiotic Investigations and Reaction Network Analysis on the Wöhler‐RNA System
ChemSystemsChem, Volume 8, Issue 2, March 2026.The prebiotic reaction toward the Wöhler‐RNA, a Proto‐RNA‐candidate, using aldehydes and biuret or triuret results in a mixture of the α‐ and β‐ furanosides and pyranosides. Investigation of the interconversion of these isomers shows different reactivity and stability of the biuret and triuret analogues as well as between the corresponding furanosides ...
Nathalie J. Kurrle +3 more
wiley +1 more source
Cardiomyocytes disrupt pyrimidine biosynthesis in nonmyocytes to regulate heart repair
The Journal of Clinical Investigation, 2022 Various populations of cells are recruited to the heart after cardiac injury, but little is known about whether cardiomyocytes directly regulate heart repair.
Shen Li +31 more
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Molecular Microbiology, Volume 125, Issue 3, Page 203-215, March 2026.Bacillus subtilis RNase HII corrects ribonucleotide errors and mismatched ribonucleotides, but not damaged ribonucleotides. Mismatched ribonucleotides would also serve as substrates for mismatch repair while damaged ribonucleotides would be addressed through base excision repair.
Julianna R. Cresti, Lyle A. Simmons
wiley +1 more source
Pentavalent Antimonials: New Perspectives for Old Drugs
Molecules, 2009 Pentavalent antimonials, including meglumine antimoniate and sodium stibogluconate, have been used for more than half a century in the therapy of the parasitic disease leishmaniasis.
Raul R. Ribeiro +2 more
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Molecules, 2013 Synthesis of 5''-phosphate 2'-O-ribosylribonucleosides [Nr(p)] of four common ribonucleosides, and 3'-phosphoramidites of 5''-phosphate 2'-O-ribosyladenosine and 2'-O-ribosylguanosine using the H-phosphonate chemistry is described.
Marcin K. Chmielewski +1 more
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Interplay between RNA‐protein interactions and RNA structures in gene regulation
FEBS Open Bio, Volume 16, Issue 2, Page 299-313, February 2026.Methodological advances in mapping transcriptome‐wide RNA‐protein interactions and RNA structures have started to uncover the potential of RNP conformations in gene regulation. Competing RNA–RNA, RNA‐protein and protein–protein interactions shape the compaction and function of RNPs throughout their lifetime and may provide novel therapeutic targets in ...
Jenni Rapakko +2 more
wiley +1 more source
Advanced Science, Volume 13, Issue 9, 13 February 2026.This study demonstrates a cuproptosis mechanism involving nicotinamide adenine dinucleotide (NADH)‐reductive stress in neural cells. Copper activates dihydrolipoamide dehydrogenase under mitochondrial pH, accumulating NADH. Copper also induces mitochondrial permeability transition pore opening, facilitating NADH translocation to the cytosol and ...
Si‐Yi Zhang +3 more
wiley +1 more source