Results 1 to 10 of about 176,411 (317)
Novel mRNA-specific effects of ribosome drop-off on translation rate and polysome profile. [PDF]
PLoS Computational Biology, 2017 The well established phenomenon of ribosome drop-off plays crucial roles in translational accuracy and nutrient starvation responses during protein translation.
Pierre Bonnin +4 more
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Mechanisms of ribosome recycling in bacteria and mitochondria: a structural perspective
RNA Biology, 2022 In all living cells, the ribosome translates the genetic information carried by messenger RNAs (mRNAs) into proteins. The process of ribosome recycling, a key step during protein synthesis that ensures ribosomal subunits remain available for new rounds ...
Savannah M. Seely, Matthieu G. Gagnon
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Ribosome biogenesis in disease: new players and therapeutic targets
Signal Transduction and Targeted Therapy, 2023 The ribosome is a multi-unit complex that translates mRNA into protein. Ribosome biogenesis is the process that generates ribosomes and plays an essential role in cell proliferation, differentiation, apoptosis, development, and transformation. The mTORC1,
Lijuan Jiao +7 more
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A Complementary Mechanism of Bacterial mRNA Translation Inhibition by Tetracyclines
Frontiers in Microbiology, 2021 Tetracycline has positively impacted human health as well as the farming and animal industries. Its extensive usage and versatility led to the spread of resistance mechanisms followed by the development of new variants of the antibiotic.
Victor Barrenechea +4 more
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Separation and Paired Proteome Profiling of Plant Chloroplast and Cytoplasmic Ribosomes
Plants, 2020 Conventional preparation methods of plant ribosomes fail to resolve non-translating chloroplast or cytoplasmic ribosome subunits from translating fractions.
Alexandre Augusto Pereira Firmino +7 more
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mTORC1 Enhances Early Phase Ribosome Processivity
Frontiers in Molecular Biosciences, 2020 During translation elongation, the ribosome serially adds amino acids to a growing polypeptide over many rounds of catalysis. The ribosome remains bound to mRNAs over these multiple catalytic cycles, requiring high processivity. Despite its importance to
Erin An, Kyle Friend
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Extraribosomal Functions of Cytosolic Ribosomal Proteins in Plants
Frontiers in Plant Science, 2021 Ribosomes are basic translational machines in all living cells. The plant cytosolic ribosome is composed of four rRNAs and approximately 81 ribosomal proteins (RPs). In addition to the fundamental functions of RPs in the messenger RNA decoding process as
Wei Xiong +4 more
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eLife, 2021 Human mitochondria express a genome that encodes thirteen core subunits of the oxidative phosphorylation system (OXPHOS). These proteins insert into the inner membrane co-translationally. Therefore, mitochondrial ribosomes engage with the OXA1L-insertase
Sven Dennerlein +12 more
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Viral and cellular translation during SARS‐CoV‐2 infection
FEBS Open Bio, 2022 SARS‐CoV‐2 is a betacoronavirus that emerged in China in December 2019 and which is the causative agent of the Covid‐19 pandemic. This enveloped virus contains a large positive‐sense single‐stranded RNA genome.
Gilbert Eriani, Franck Martin
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Characterization of HicAB toxin-antitoxin module of Sinorhizobium meliloti
BMC Microbiology, 2019 Background Toxin-antitoxin (TA) systems are little genetic units generally composed of two genes encoding antitoxin and toxin. These systems are known to be involved in many functions that can lead to growth arrest and cell death.
Manon Thomet +3 more
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