Results 1 to 10 of about 343,033 (331)

Fibrillarin-mediated ribosomal RNA maturation is a novel therapeutic vulnerability in triple-negative breast cancer [PDF]

Breast Cancer Research
Background Triple-negative breast cancer (TNBC) remains one of the most challenging breast cancer subtypes to treat due to the lack of effective therapeutic options.
Camille Jouines, Piero Lo Monaco, Angéline Gaucherot, Julie Radermecker, Caroline Isaac, Fleur Bourdelais, Marie-Ambre Monet, Marion Meyer, Mounira Chalabi-Dchar, Flora Nguyen Van Long, Laury Baillon, Carine Froment, Julien Marcoux, Christophe Vanbelle, Tanguy Fenouil, Sébastien Durand, Stéphane Giraud, Jean-Jacques Diaz, Virginie Marcel, Frédéric Catez   +19 more
doaj   +2 more sources

The evolutionary lifecycle of ribosome hibernation factors [PDF]

Melnikov S, Chan L, Omae K, Brown C, Amikura K, Ekemezie C, Clark J, Nishide K, Helena-Bueno K, Palmowski P, Porter A, Suzuki S.   +11 more
europepmc   +2 more sources

Novel mRNA-specific effects of ribosome drop-off on translation rate and polysome profile. [PDF]

PLoS Computational Biology, 2017
The well established phenomenon of ribosome drop-off plays crucial roles in translational accuracy and nutrient starvation responses during protein translation.
Pierre Bonnin, Norbert Kern, Neil T Young, Ian Stansfield, M Carmen Romano   +4 more
doaj   +1 more source

Mechanisms of ribosome recycling in bacteria and mitochondria: a structural perspective

RNA Biology, 2022
In all living cells, the ribosome translates the genetic information carried by messenger RNAs (mRNAs) into proteins. The process of ribosome recycling, a key step during protein synthesis that ensures ribosomal subunits remain available for new rounds ...
Savannah M. Seely, Matthieu G. Gagnon
doaj   +1 more source

Ribosome biogenesis in disease: new players and therapeutic targets

Signal Transduction and Targeted Therapy, 2023
The ribosome is a multi-unit complex that translates mRNA into protein. Ribosome biogenesis is the process that generates ribosomes and plays an essential role in cell proliferation, differentiation, apoptosis, development, and transformation. The mTORC1,
Lijuan Jiao, Yuzhe Liu, Xi-Yong Yu, Xiangbin Pan, Yu Zhang, Junchu Tu, Yao-Hua Song, Yangxin Li   +7 more
doaj   +1 more source

mTORC1 Enhances Early Phase Ribosome Processivity

Frontiers in Molecular Biosciences, 2020
During translation elongation, the ribosome serially adds amino acids to a growing polypeptide over many rounds of catalysis. The ribosome remains bound to mRNAs over these multiple catalytic cycles, requiring high processivity. Despite its importance to
Erin An, Kyle Friend
doaj   +1 more source

Separation and Paired Proteome Profiling of Plant Chloroplast and Cytoplasmic Ribosomes

Plants, 2020
Conventional preparation methods of plant ribosomes fail to resolve non-translating chloroplast or cytoplasmic ribosome subunits from translating fractions.
Alexandre Augusto Pereira Firmino, Michal Gorka, Alexander Graf, Aleksandra Skirycz, Federico Martinez-Seidel, Kerstin Zander, Joachim Kopka, Olga Beine-Golovchuk   +7 more
doaj   +1 more source

Impact of Ribosome Activity on SARS-CoV-2 LNP – Based mRNA Vaccines

Frontiers in Molecular Biosciences, 2021
Coronavirus-related Severe Acute Respiratory Syndrome-2 (SARS-CoV-2) initially was detected in Wuhan, Hubei, China. Since early 2021, World Health Organization (WHO) has declared Coronavirus Disease 2019 (COVID-19) a pandemic due to rapidly transformed ...
Evangelos Tsiambas, Evangelos Tsiambas, Evangelos Tsiambas, Aristeidis Chrysovergis, Vasileios Papanikolaou, Nicholas Mastronikolis, Vasileios Ragos, Anna Batistatou, Dimitrios Peschos, Nikolaos Kavantzas, Andreas C. Lazaris, Efthimios Kyrodimos   +11 more
doaj   +1 more source

A comprehensive coverage insurance for cells: revealing links between ribosome collisions, stress responses and mRNA surveillance

RNA Biology, 2022
Cells of metazoans respond to internal and external stressors by activating stress response pathways that aim for re-establishing cellular homoeostasis or, if this cannot be achieved, triggering programmed cell death. Problems during translation, arising
Soumasree De, Oliver Mühlemann
doaj   +1 more source

Characterization of HicAB toxin-antitoxin module of Sinorhizobium meliloti

BMC Microbiology, 2019
Background Toxin-antitoxin (TA) systems are little genetic units generally composed of two genes encoding antitoxin and toxin. These systems are known to be involved in many functions that can lead to growth arrest and cell death.
Manon Thomet, Annie Trautwetter, Gwennola Ermel, Carlos Blanco   +3 more
doaj   +1 more source