Results 1 to 10 of about 406,930 (327)

Ribosome biogenesis in disease: new players and therapeutic targets

Signal Transduction and Targeted Therapy, 2023
The ribosome is a multi-unit complex that translates mRNA into protein. Ribosome biogenesis is the process that generates ribosomes and plays an essential role in cell proliferation, differentiation, apoptosis, development, and transformation. The mTORC1,
Lijuan Jiao, Yuzhe Liu, Xi-Yong Yu, Xiangbin Pan, Yu Zhang, Junchu Tu, Yao-Hua Song, Yangxin Li   +7 more
doaj   +2 more sources

Fibrillarin-mediated ribosomal RNA maturation is a novel therapeutic vulnerability in triple-negative breast cancer [PDF]

Breast Cancer Research
Background Triple-negative breast cancer (TNBC) remains one of the most challenging breast cancer subtypes to treat due to the lack of effective therapeutic options.
Camille Jouines, Piero Lo Monaco, Angéline Gaucherot, Julie Radermecker, Caroline Isaac, Fleur Bourdelais, Marie-Ambre Monet, Marion Meyer, Mounira Chalabi-Dchar, Flora Nguyen Van Long, Laury Baillon, Carine Froment, Julien Marcoux, Christophe Vanbelle, Tanguy Fenouil, Sébastien Durand, Stéphane Giraud, Jean-Jacques Diaz, Virginie Marcel, Frédéric Catez   +19 more
doaj   +2 more sources

EDF1 coordinates cellular responses to ribosome collisions

eLife, 2020
Translation of aberrant mRNAs induces ribosomal collisions, thereby triggering pathways for mRNA and nascent peptide degradation and ribosomal rescue.
Niladri K Sinha, Alban Ordureau, Katharina Best, James A Saba, Boris Zinshteyn, Elayanambi Sundaramoorthy, Amit Fulzele, Danielle M Garshott, Timo Denk, Matthias Thoms, Joao A Paulo, J Wade Harper, Eric J Bennett, Roland Beckmann, Rachel Green   +14 more
doaj   +2 more sources

Heterogeneity in responses to ribosome-targeting antibiotics mediated by bacterial RNA repair. [PDF]

Nat Commun
Hindley HJ, Gong Z, Moradian S, Giuliano MG, Sapelkin A, Kotta-Loizou I, Buck M, Engl C, Weiße AY.   +8 more
europepmc   +3 more sources

Ribosome biogenesis factors—from names to functions

EMBO Journal, 2023
The assembly of ribosomal subunits is a highly orchestrated process that involves a huge cohort of accessory factors. Most eukaryotic ribosome biogenesis factors were first identified by genetic screens and proteomic approaches of pre‐ribosomal particles
Kerstin Dörner, C. Ruggeri, I. Zemp, U. Kutay   +3 more
semanticscholar   +1 more source

Ribosome Biogenesis: A Central Player in Cancer Metastasis and Therapeutic Resistance

Cancer Research, 2022
Ribosomes are a complex ensemble of rRNA and ribosomal proteins that function as mRNA translation machines. Ribosome biogenesis is a multistep process that begins in the nucleolus and concludes in the cytoplasm.
Amr R. Elhamamsy, Brandon J. Metge, H. Alsheikh, L. Shevde, Rajeev S. Samant   +4 more
semanticscholar   +1 more source

Novel mRNA-specific effects of ribosome drop-off on translation rate and polysome profile. [PDF]

PLoS Computational Biology, 2017
The well established phenomenon of ribosome drop-off plays crucial roles in translational accuracy and nutrient starvation responses during protein translation.
Pierre Bonnin, Norbert Kern, Neil T Young, Ian Stansfield, M Carmen Romano   +4 more
doaj   +1 more source

Mechanisms of ribosome recycling in bacteria and mitochondria: a structural perspective

RNA Biology, 2022
In all living cells, the ribosome translates the genetic information carried by messenger RNAs (mRNAs) into proteins. The process of ribosome recycling, a key step during protein synthesis that ensures ribosomal subunits remain available for new rounds ...
Savannah M. Seely, Matthieu G. Gagnon
doaj   +1 more source

Ribosome Biogenesis and Cancer: Overview on Ribosomal Proteins

International Journal of Molecular Sciences, 2021
Cytosolic ribosomes (cytoribosomes) are macromolecular ribonucleoprotein complexes that are assembled from ribosomal RNA and ribosomal proteins, which are essential for protein biosynthesis.
Annalisa Pecoraro, Martina Pagano, G. Russo, A. Russo   +3 more
semanticscholar   +1 more source

mTORC1 Enhances Early Phase Ribosome Processivity

Frontiers in Molecular Biosciences, 2020
During translation elongation, the ribosome serially adds amino acids to a growing polypeptide over many rounds of catalysis. The ribosome remains bound to mRNAs over these multiple catalytic cycles, requiring high processivity. Despite its importance to
Erin An, Kyle Friend
doaj   +1 more source