Results 1 to 10 of about 358,575 (311)

Ribosome biogenesis in disease: new players and therapeutic targets

Signal Transduction and Targeted Therapy, 2023
The ribosome is a multi-unit complex that translates mRNA into protein. Ribosome biogenesis is the process that generates ribosomes and plays an essential role in cell proliferation, differentiation, apoptosis, development, and transformation. The mTORC1,
Lijuan Jiao, Yuzhe Liu, Xi-Yong Yu, Xiangbin Pan, Yu Zhang, Junchu Tu, Yao-Hua Song, Yangxin Li   +7 more
doaj   +2 more sources

Ribosome Biogenesis and Cancer: Overview on Ribosomal Proteins [PDF]

International Journal of Molecular Sciences, 2021
Cytosolic ribosomes (cytoribosomes) are macromolecular ribonucleoprotein complexes that are assembled from ribosomal RNA and ribosomal proteins, which are essential for protein biosynthesis. Mitochondrial ribosomes (mitoribosomes) perform translation of the proteins essential for the oxidative phosphorylation system. The biogenesis of cytoribosomes and
Pecoraro Annalisa, Pagano Martina, Russo Giulia, Russo Annapina   +3 more
openaire   +4 more sources

YebC2 resolves ribosome stalling and increases fitness of cells lacking EF-P and the ABCF ATPase YfmR. [PDF]

PLoS Genet
Ribosome stalling is a major source of cellular stress. Therefore, many specialized elongation factors help prevent ribosome stalling. One of the best characterized of these factors is EF-P, which prevents ribosome stalling at polyproline tracts and ...
Hong HR, Prince CR, Wu L, Lin IN, Callan K, Feaga HA.   +5 more
europepmc   +2 more sources

Direct measurement of the mechanical work during translocation by the ribosome. [PDF]

eLife, 2014
A detailed understanding of tRNA/mRNA translocation requires measurement of the forces generated by the ribosome during this movement. Such measurements have so far remained elusive and, thus, little is known about the relation between force and ...
Alexander, Lisa, BUSTAMANTE, Carlos J., Fredrick, Kurt, Kaplan, Ariel, Lancaster, Laura, Liu, Tingting, Noller, Harry, Tinoco, Ignacio, Wen, Jin-Der, Wickersham, Charles, Yan, Shannon   +10 more
core   +4 more sources

Ribosome-omics of the human ribosome [PDF]

RNA, 2014
The torrent of RNA-seq data becoming available not only furnishes an overview of the entire transcriptome but also provides tools to focus on specific areas of interest. Our focus on the synthesis of ribosomes asked whether the abundance of mRNAs encoding ribosomal proteins (RPs) matched the equimolar need for the RPs in the assembly of ribosomes.
Jonathan R. Warner, Varun Gupta
openaire   +3 more sources

Novel mRNA-specific effects of ribosome drop-off on translation rate and polysome profile. [PDF]

PLoS Computational Biology, 2017
The well established phenomenon of ribosome drop-off plays crucial roles in translational accuracy and nutrient starvation responses during protein translation.
Pierre Bonnin, Norbert Kern, Neil T Young, Ian Stansfield, M Carmen Romano   +4 more
doaj   +1 more source

Bacterial Ribosome Rescue Systems

Microorganisms, 2022
To maintain proteostasis, the cell employs multiple ribosome rescue systems to relieve the stalled ribosome on problematic mRNA. One example of problematic mRNA is non-stop mRNA that lacks an in-frame stop codon produced by endonucleolytic cleavage or ...
Daisuke Kurita, Hyouta Himeno
doaj   +1 more source

Mechanisms of ribosome recycling in bacteria and mitochondria: a structural perspective

RNA Biology, 2022
In all living cells, the ribosome translates the genetic information carried by messenger RNAs (mRNAs) into proteins. The process of ribosome recycling, a key step during protein synthesis that ensures ribosomal subunits remain available for new rounds ...
Savannah M. Seely, Matthieu G. Gagnon
doaj   +1 more source

mTORC1 Enhances Early Phase Ribosome Processivity

Frontiers in Molecular Biosciences, 2020
During translation elongation, the ribosome serially adds amino acids to a growing polypeptide over many rounds of catalysis. The ribosome remains bound to mRNAs over these multiple catalytic cycles, requiring high processivity. Despite its importance to
Erin An, Kyle Friend
doaj   +1 more source

The mitochondrial ribosome and ribosomal RNA of the chick [PDF]

FEBS Letters, 1971
Reports have appeared on large molecular weight RNAs associated with the mitochondria of higher organisms. These include HeLa cells [ 1 ] , BHK-2 1 cells [2] , mouse L-cells [3,4] , rat liver [4, S] and Xenopus ovary [6] . This RNA consists of two predominant species found to be 17 S and 13 S by sedimentation [2, 31 .
Terence H. Rabbitts, T.S. Work
openaire   +3 more sources