Results 221 to 230 of about 244,255 (294)

MDL‐800‐induced SIRT6 activation decreases age‐associated osteoarthritis in mice

Arthritis &Rheumatology, Accepted Article.
Objective SIRT6 is a nuclear‐localized histone deacetylase that regulates multiple pathways associated with aging. This study aimed to determine whether systemic administration of a small molecule activator of SIRT6, MDL‐800, decreases the severity of age‐associated osteoarthritis (OA) in mice.
Matheus Moreira Perez, Pranay Ramteke, Bahiyah Watson, Owen Haslam, Eirene Choi, Susan Chubinskaya, Mandy J. Peffers, William R. Davis, Jacqueline Shine, Brian O. Diekman, Richard F. Loeser, Theresa A. Freeman, Makarand V. Risbud, John A. Collins   +13 more
wiley   +1 more source

Mitochondrial Remodeling, Cytoskeletal Dynamics, and Translational Control During <i>Drosophila</i> Spermatid Elongation: An Integrative Review. [PDF]

Biology (Basel)
Fang Y, Yin J, Chen L, Zhang F, Liu Y, Ma L, Liu X, Luo Y, He H, Xie Q.   +9 more
europepmc   +1 more source

Biochemical Studies and Production Optimization of β‐Glucosidase From Microcystis aeruginosa CACIAM 03 Using Organic Waste

Biotechnology and Applied Biochemistry, EarlyView.
ABSTRACT Global warming and industrial pollutants pose significant threats to environmental sustainability. In response, enzymes have emerged as promising tools for mitigating pollution. Enzymatic hydrolysis is considered environmentally sustainable due to its biological nature.
Gustavo Marques Serra, Matheus Silva da Fonseca Diniz, Evonnildo Costa Gonçalves, Agenor Valadares Santos, Luciana Pereira Xavier   +4 more
wiley   +1 more source

RPL41 stabilizes ribosome dynamics and supports long-protein homeostasis in mammals. [PDF]

Nucleic Acids Res
Hirata M, Fujino M, Ichihara K, Tang R, Narita M, Iwasaki W, Shiraishi C, Shiraishi T, Hatano A, Suzuki T, Abe T, Takami T, Mishiro-Sato E, Toyoda A, Matsumoto M, Tanaka Y, Ito T, Inada T, Nakayama KI, Yokoyama T, Matsumoto A.   +20 more
europepmc   +1 more source

Impact of Agitation Power Input on Aspergillus oryzae Metabolism: Application of Multi‐Omics on an Industrial Enzyme Fermentation

Biotechnology and Bioengineering, EarlyView.
ABSTRACT The agitation power input substantially impacts the oxygen transfer rate in aerobic fermentation processes. Furthermore, in a carbon‐limited process where the substrate feed rate is controlled by the concentration of dissolved oxygen, the power input will consequently govern the feed rate.
Mariana Albino, Jean‐Marie Mouillon, Gisela Nadal‐Rey, Carina L. Gargalo, Ulrich Krühne, Krist V. Gernaey, Mads O. Albæk   +6 more
wiley   +1 more source

Regulatory dynamics of monosomes and polysomes in cellular adaptation. [PDF]

J Biochem
Imai H, Yamashita A.
europepmc   +1 more source

Species Dynamics and Gene Expression in Algal Polycultures Under Mixotrophic Cultivation in Outdoor Pilot‐Scale Nordic Conditions

Biotechnology and Bioengineering, EarlyView.
These results demonstrate that mixotrophic conditions drive both microbial community shifts and metabolic reprogramming, underscoring the importance of cultivation strategy and polyculture selection for targeted applications such as nutrient recovery and bioproduct generation.
Quyen Nham, Hanna Farnelid, Catherine Legrand, Elin Lindehoff   +3 more
wiley   +1 more source

seq2ribo: structure-aware integration of machine learning and simulation to predict ribosome location profiles from RNA sequences. [PDF]

Bioinformatics
Kaynar G, Kingsford C.
europepmc   +1 more source

Induction and Enhancement of Bacteriocin Production (Review)

Biotechnology and Bioengineering, EarlyView.
ABSTRACT Conventionally, bacteriocins are produced by microorganisms on complex substrates, released as semi‐purified preparations or crude fermentates. These bacteriocin‐containing products often exhibit unsatisfactory purity, low active‐substance content, and high production costs, limiting their commercialization and use. This review aims to analyze
Oksana Knysh, Artur Martynov
wiley   +1 more source

Development of Semisynthetic Blasticidin S Analogs with Potent and Fast-Killing Antimalarial Activity. [PDF]

ACS Infect Dis
Fike KR, Gannett C, Kiselka AM, Tiller K, Ajasa T, Weger-Lucarelli J, Brown AM, Lowell AN, Klemba M.   +8 more
europepmc   +1 more source