Cytotoxicity Effect of Quinoin, Type 1 Ribosome-Inactivating Protein from Quinoa Seeds, on Glioblastoma Cells [PDF]
Toxins, 2021 Ribosome-inactivating proteins (RIPs) are found in several edible plants and are well characterized. Many studies highlight their use in cancer therapy, alone or as immunoconjugates, linked to monoclonal antibodies directed against target cancer cells ...
Rossella Rotondo +7 more
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Toxins, 2022 Ribosome-inactivating proteins (RIPs) are known as RNA N-glycosylases. They depurinate the major rRNA, damaging ribosomes and inhibiting protein synthesis.
Nicola Landi +7 more
doaj +4 more sources
Iris Bulbs Express Type 1 and Type 2 Ribosome-Inactivating Proteins with Unusual Properties [PDF]
Plant Physiology, 2001 Abstract Two closely related lectins from bulbs of the Dutch iris (Iris hollandica var. Professor Blaauw) have been isolated and cloned. Both lectins, called Iris agglutinin b and Iris agglutinin r, possess N-glycosidase activity and share a high sequence similarity with previously described type 2 ribosome-inactivating proteins (RIP ...
Q, Hao +6 more
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Inhibition of HIV-1 replication by balsamin, a ribosome inactivating protein of Momordica balsamina. [PDF]
PLoS ONE, 2013 Ribosome-inactivating proteins (RIPs) are endowed with several medicinal properties, including antiviral activity. We demonstrate here that the recently identified type I RIP from Momordica balsamina also possesses antiviral activity, as determined by ...
Inderdeep Kaur +5 more
doaj +7 more sources
Toxins, 2022 Ribosome-inactivating proteins (RIPs) are a group of proteins with rRNA N-glycosylase activity that catalyze the removal of a specific adenine located in the sarcin–ricin loop of the large ribosomal RNA, which leads to the irreversible inhibition of ...
Rosario Iglesias +8 more
doaj +2 more sources
Comparison of the Embryotoxic Effects of Saporin, Agrostin (Type 1 Ribosome-Inactivating Proteins) and Ricin (a Type 2 Ribosome-Inactivating Protein [PDF]
Pharmacology and Toxicology, 2001 Abstract: The effects of two type I ribosome‐inactivating proteins, saporin and agrostin, and the type 2 ribosome‐inactivating protein ricin and its constituent A and B chains, on the development of cultured mouse embryos, were investigated. Saporin and agrostin had similar embryotoxicity which was approximately 105 times weaker than that of ricin and ...
W Y, Chan, T B, Ng
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Dianthin and Its Potential in Targeted Tumor Therapies [PDF]
Toxins, 2019 Dianthin enzymes belong to ribosome-inactivating proteins (RIPs) of type 1, i.e., they only consist of a catalytic domain and do not have a cell binding moiety.
Hendrik Fuchs
doaj +3 more sources
Recombinant tritin protein exhibits antiviral activity against zucchini yellow mosaic virus [PDF]
BMC Plant BiologyBackground Ribosome-inactivating proteins (RIPs) are a group of proteins known to inhibit protein synthesis and contribute to plant defense responses. Although the antiviral properties of various RIPs have been demonstrated, the antiviral potential of ...
Serap Demi̇rel +3 more
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Biocontrol Potential of Sodin 5, Type 1 Ribosome-Inactivating Protein from Salsola soda L. Seeds
BiomoleculesSodin 5 is a type 1 ribosome-inactivating protein isolated from the seeds of Salsola soda L., an edible halophytic plant that is widespread in southern Europe, close to the coast.
Monika Novak Babič +8 more
doaj +4 more sources
Charged and hydrophobic surfaces on the a chain of shiga-like toxin 1 recognize the C-terminal domain of ribosomal stalk proteins. [PDF]
PLoS ONE, 2012 Shiga-like toxins are ribosome-inactivating proteins (RIP) produced by pathogenic E. coli strains that are responsible for hemorrhagic colitis and hemolytic uremic syndrome.
Andrew J McCluskey +5 more
doaj +1 more source