Recommended Immunological Assays to Screen for Ricin-Containing Samples [PDF]
Toxins, 2015 Ricin, a toxin from the plant Ricinus communis, is one of the most toxic biological agents known. Due to its availability, toxicity, ease of production and absence of curative treatments, ricin has been classified by the Centers for Disease Control and ...
Stéphanie Simon +8 more
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Ricin Toxicity to Intestinal Cells Leads to Multiple Cell Death Pathways Mediated by Oxidative Stress [PDF]
ToxinsRicin, a type 2 ribosome-inactivating protein, is a lethal toxin found in castor bean seeds. Although the systemic toxicity of ricin has been extensively studied, its localized effect on the gastrointestinal tract remains a critical concern, particularly
Francesco Biscotti +5 more
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A Monoclonal Antibody with a High Affinity for Ricin Isoforms D and E Provides Strong Protection against Ricin Poisoning [PDF]
ToxinsRicin is a highly potent toxin that has been used in various attempts at bioterrorism worldwide. Although a vaccine for preventing ricin poisoning (RiVax™) is in clinical development, there are currently no commercially available prophylaxis or ...
Loïs Lequesne +11 more
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Ricin Toxin Activates the NALP3 Inflammasome [PDF]
Toxins, 2010 Ricin exhibits well characterized ribotoxic actions that lead to the inhibition of protein synthesis and the phosphorylation of stress activated protein kinases (SAPKs).
Meghan Lindauer, John Wong, Bruce Magun
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Isolation of a human-like antibody fragment (scFv) that neutralizes ricin biological activity [PDF]
BMC Biotechnology, 2009 Background Ricin is a lethal toxin that inhibits protein synthesis. It is easily extracted from a ubiquitously grown plant, Ricinus communis, and thus readily available for use as a bioweapon (BW). Anti-ricin antibodies provide the only known therapeutic
Thullier Philippe +5 more
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Combining deep mutational scanning and SPR binning approaches for large-scale epitope identification of anti-ricin antibodies [PDF]
mAbsRicin, a ribosome-inactivating lectin from Ricinus communis seeds, has been used as a bioterrorism agent in multiple cases. While passive immunotherapy with anti-ricin antibodies shows promise in preclinical studies, no approved countermeasure exists ...
Ophélie Kot +10 more
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Intracellular Transport and Cytotoxicity of the Protein Toxin Ricin
Toxins, 2019 Ricin can be isolated from the seeds of the castor bean plant (Ricinus communis). It belongs to the ribosome-inactivating protein (RIP) family of toxins classified as a bio-threat agent due to its high toxicity, stability and availability.
Natalia Sowa-Rogozińska +2 more
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Investigating diversity and similarity between CBM13 modules and ricin-B lectin domains using sequence similarity networks [PDF]
BMC GenomicsBackground The CBM13 family comprises carbohydrate-binding modules that occur mainly in enzymes and in several ricin-B lectins. The ricin-B lectin domain resembles the CBM13 module to a large extent.
Tibo De Coninck +4 more
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Development of a Graphene Oxide-Based Aptamer Nanoarray for Improved Neutralization and Protection Effects Against Ricin [PDF]
PharmaceuticsBackground/Objectives: Ricin’s high toxicity and potential as a bioweapon underscore the need for effective antidotes. Monoclonal antibodies, though effective, are limited by complex production.
Huafei Li +7 more
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Purified Immunoglobulin F(ab′) 2 Protects Mice and Rhesus Monkeys against Lethal Ricin Intoxication
Zoonoses, 2023 Ricin is a highly toxic ribosome-inactivating lectin derived from castor beans. To date, no antidote is available to treat ricin-poisoned patients, and the development of a safe and effective antidote is urgently needed.
Jingjing Tian +16 more
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