Results 11 to 20 of about 25,369 (260)

Autophagic Degradation Is Involved in Cell Protection against Ricin Toxin

Toxins, 2023
Autophagy is a complex and highly regulated degradative process, which acts as a survival pathway in response to cellular stress, starvation and pathogen infection.
Yu Wu, Clémence Taisne, Nassim Mahtal, Alison Forrester, Marion Lussignol, Jean-Christophe Cintrat, Audrey Esclatine, Daniel Gillet, Julien Barbier   +8 more
doaj   +1 more source

Novel small molecule retrograde transport blocker confers post-exposure protection against ricin intoxication

Acta Pharmaceutica Sinica B, 2020
Ricin is a highly toxic type 2 ribosome-inactivating protein (RIP) which is extracted from the seeds of castor beans. Ricin is considered a potential bioterror agent and no effective antidote for ricin exists so far.
Xu Zhao, Haixia Li, Jia Li, Kunlu Liu, Bo Wang, Yuxia Wang, Xingzhou Li, Wu Zhong   +7 more
doaj   +1 more source

RIPpore: A Novel Host-Derived Method for the Identification of Ricin Intoxication through Oxford Nanopore Direct RNA Sequencing

Toxins, 2022
Ricin is a toxin which enters cells and depurinates an adenine base in the sarcin-ricin loop in the large ribosomal subunit, leading to the inhibition of protein translation and cell death.
Yan Ryan, Abbie Harrison, Hannah Trivett, Catherine Hartley, Jonathan David, Graeme C. Clark, Julian A. Hiscox   +6 more
doaj   +1 more source

Influence of environmental conditions on the attenuation of ricin toxin on surfaces. [PDF]

PLoS ONE, 2018
Ricin is a highly-toxic compound derived from castor plant beans. Several incidents involving contamination of residences and buildings due to ricin production or dissemination have occurred in recent years.
Joseph P Wood, William Richter, M Autumn Smiley, James V Rogers   +3 more
doaj   +1 more source

Cytosolic chaperones influence the fate of a toxin dislocated from the endoplasmic reticulum [PDF]

, 2008
The plant cytotoxin ricin enters target mammalian cells by receptor-mediated endocytosis and undergoes retrograde transport to the endoplasmic reticulum (ER).
Argent, Argent, Arndt, Brodsky, Brodsky, C. Rogon, Chaddock, Chen, Hudson, Hundley, H  hfeld, J. Hohfeld, J. M. Lord, J. P. Cook, L. M. Roberts, Lawson, Luders, Meacham, Meusser, Nakatsukasa, Nakatsukasa, P. J. Hart, P. Pietroni, R. A. Spooner, Rapak, Roe, Savino, Spooner, Urushitani, van Deurs, Wales, Wesche, Younger   +32 more
core   +4 more sources

Ricin crosses polarized human intestinal cells and intestines of ricin-gavaged mice without evident damage and then disseminates to mouse kidneys. [PDF]

PLoS ONE, 2013
Ricin is a potent toxin found in the beans of Ricinus communis and is often lethal for animals and humans when aerosolized or injected and causes significant morbidity and occasional death when ingested.
Alyssa D Flora, Louise D Teel, Mark A Smith, James F Sinclair, Angela R Melton-Celsa, Alison D O'Brien   +5 more
doaj   +1 more source

Ricin B chain targeted to the endoplasmic reticulum of tobacco protoplasts is degraded by a CDC48- and vacuole-independent mechanism [PDF]

, 2008
The B chain of ricin was expressed and delivered to the endoplasmic reticulum of tobacco protoplasts where it disappeared with time in a manner consistent with degradation. This turnover did not occur in the vacuoles or upon secretion.
Asher, Bakker, Barlowe, Barlowe, Benatti, Blanchard, Brandizzi, Brauer, Braun, Carter, Contento, d'Enfert, d'Enfert, de Virgilio, Di Cola, Di Cola, Donoso, Ellgaard, Endo, Feiler, Fenteany, Ferrini, Frigerio, Frigerio, Frigerio, Frigerio, Frigerio, Gillespie, Glas, Hellens, Hong, Jarosch, Jolliffe, Jolliffe, Katiyar, Kisselev, Kong, Lord, Lord, Loureiro, Ma, Maliga, Marshall, Meng, Meusser, Muller, Nebenfuhr, Nuttall, Nuttall, Parodi, Pedrazzini, Phillipson, Pimpl, Rancour, Reichel, Roberts, Romisch, Saint-Jore-Dupas, Schmitz, Schmitz, Sheng, Smith, Speranza, Tabe, Taiz, Tamura, Tolchinsky, Tormakangas, Tsai, Vitale, Wales, Ye, Ye, Yuk   +73 more
core   +2 more sources

Intramuscular Ricin Poisoning of Mice Leads to Widespread Damage in the Heart, Spleen, and Bone Marrow

Toxins, 2019
Ricin, a lethal toxin derived from castor oil beans, is a potential bio-threat due to its high availability and simplicity of preparation. Ricin is prepared according to simple recipes available on the internet, and was recently considered in terrorist ...
Anita Sapoznikov, Amir Rosner, Reut Falach, Yoav Gal, Moshe Aftalion, Yentl Evgy, Ofir Israeli, Tamar Sabo, Chanoch Kronman   +8 more
doaj   +1 more source

Ricin Antibodies’ Neutralizing Capacity against Different Ricin Isoforms and Cultivars

Toxins, 2021
Ricin, a highly toxic protein from Ricinus communis, is considered a potential biowarfare agent. Despite the many data available, no specific treatment has yet been approved.
Maria Lucia Orsini Delgado, Arnaud Avril, Julie Prigent, Julie Dano, Audrey Rouaix, Sylvia Worbs, Brigitte G. Dorner, Clémence Rougeaux, François Becher, François Fenaille, Sandrine Livet, Hervé Volland, Jean-Nicolas Tournier, Stéphanie Simon   +13 more
doaj   +1 more source

Reversibility of cell surface label rearrangement [PDF]

, 1976
Cell surface labeling can cause rearrangements of randomly distributed membrane components. Removal of the label bound to the cell surface allows the membrane components to return to their original random distribution, demonstrating that label is ...
Brown, Susan Smith, Revel, Jean-Paul
core   +1 more source