Results 21 to 30 of about 25,369 (260)

Ricin toxicokinetics and its sensitive detection in mouse sera or feces using immuno-PCR. [PDF]

PLoS ONE, 2010
Ricin (also called RCA-II or RCA(60)), one of the most potent toxins and documented bioweapons, is derived from castor beans of Ricinus communis. Several in vitro methods have been designed for ricin detection in complex food matrices in the event of ...
Xiaohua He, Stephanie McMahon, Thomas D Henderson, Stephen M Griffey, Luisa W Cheng   +4 more
doaj   +1 more source

Differential ER stress as a driver of cell fate following ricin toxin exposure

FASEB BioAdvances, 2022
Inhalation of trace amounts of ricin toxin, a plant‐derived ribosome‐inactivating protein, results in ablation of alveolar macrophages, widespread epithelial damage, and the onset of acute respiratory distress syndrome (ARDS). While ricin's receptors are
Claire Peterson‐Reynolds, Nicholas J. Mantis   +1 more
doaj   +1 more source

A human embryonic kidney 293T cell line mutated at the Golgi -mannosidase II locus [PDF]

, 2009
Disruption of Golgi -mannosidase II activity can result in type II congenital dyserythropoietic anemia and can induce lupus-like autoimmunity in mice.
Max Crispin, Veronica T. Chang, David J. Harvey, Raymond A. Dwek, Edward J. Evans, David I. Stuart, E. Yvonne Jones, J. Michael Lord, Robert A. Spooner, Simon J. Davis, Kornfeld, Balaguer, Neusüss, Parodi, Herscovics, Tremblay, Lal, Schachter, Jaeken, Fukuda, Fukuda, Lowe, Green, Paulson, Patnaik, Martinez-Duncker, Hong, Sethuraman, Hoppe, Davis, Davis, Butters, Chang, Stanley, Dwek, Hamilton, Li, Hamilton, Reeves, Gleeson, Hughes, Hughes, Foddy, Paschinger, Aghi, Bebbington, Davis, Aricescu, Durocher, Küster, Börnsen, Harvey, Harvey, Harvey, Harvey, Olsnes, Watson, Spooner, Spooner, Crispin, Crispin, Oh-Eda, Harvey, Domon, Chen, Shah, Moremen, Butler, Choi, Wu, Foulquier   +70 more
core   +2 more sources

Role of Phospholipase A2 in Retrograde Transport of Ricin

Toxins, 2011
Ricin is a protein toxin classified as a bioterror agent, for which there are no known treatment options available after intoxication. It is composed of an enzymatically active A-chain connected by a disulfide bond to a cell binding B-chain.
Kirsten Sandvig, Anne Berit Dyve Lingelem, Anne-Grethe Myrann, Tove Irene Klokk   +3 more
doaj   +1 more source

Crystal Structure of the Cysteine-Rich Domain of Mannose Receptor Complexed with a Sulfated Carbohydrate Ligand [PDF]

, 2000
The macrophage and epithelial cell mannose receptor (MR) binds carbohydrates on foreign and host molecules. Two portions of MR recognize carbohydrates: tandemly arranged C-type lectin domains facilitate carbohydrate-dependent macrophage uptake of ...
Bjorkman, Pamela J., Chirino, Arthur J., Feizi, Ten, Leteux, Christine, Liu, Yang, Misulovin, Ziva, Nussenzweig, Michel C.   +6 more
core   +2 more sources

Ricin and Ricin-Containing Immunotoxins: Insights into Intracellular Transport and Mechanism of action in Vitro

Antibodies, 2013
Ricin is a type II ribosome inactivating protein (RIP) isolated from castor beans. Its high toxicity classifies it as a possible biological weapon. On the other hand, ricin linked to specific monoclonal antibodies or used in other conjugates has powerful
Monika Słomińska-Wojewódzka, Kirsten Sandvig   +1 more
doaj   +1 more source

Active Immunity Induced by Passive IgG Post-Exposure Protection against Ricin

Toxins, 2014
Therapeutic antibodies can confer an instant protection against biothreat agents when administered. In this study, intact IgG and F(ab’)2 from goat anti-ricin hyperimmune sera were compared for the protection against lethal ricin mediated intoxication ...
Charles Chen Hu, Junfei Yin, Damon Chau, John W. Cherwonogrodzky, Wei-Gang Hu   +4 more
doaj   +1 more source

Characterization of Ricin and R. communis Agglutinin Reference Materials

Toxins, 2015
Ricinus communis intoxications have been known for centuries and were attributed to the toxic protein ricin. Due to its toxicity, availability, ease of preparation, and the lack of medical countermeasures, ricin attracted interest as a potential ...
Sylvia Worbs, Martin Skiba, Martin Söderström, Marja-Leena Rapinoja, Reinhard Zeleny, Heiko Russmann, Heinz Schimmel, Paula Vanninen, Sten-Åke Fredriksson, Brigitte G. Dorner   +9 more
doaj   +1 more source

Retrograde transport pathways utilised by viruses and protein toxins [PDF]

, 2006
A model has been presented for retrograde transport of certain toxins and viruses from the cell surface to the ER that suggests an obligatory interaction with a glycolipid receptor at the cell surface. Here we review studies on the ER trafficking cholera
Easton, A. J. (Andrew J.), Lord, Mike, Roberts, L. M. (Lynne M.), Smith, Daniel C., Spooner, Robert A.   +4 more
core   +2 more sources

The proteasome cap RPT5/Rpt5p subunit prevents aggregation of unfolded ricin A chain [PDF]

, 2013
The plant cytotoxin ricin enters mammalian cells by receptor-mediated endocytosis, undergoing retrograde transport to the endoplasmic reticulum (ER) where its catalytic A chain (RTA) is reductively separated from the holotoxin to enter the cytosol and ...
Afshar, Allen, Argent, Bays, Bellisola, Blum, Braun, Brodsky, Carvalho, Cascio, Craiu, David M. Roberts, Deeks, Elkabetz, Endo, Fiani, Fleming, Fu, Gallastegui, Giodini, Groll, Hartley, Hazes, Heiligenstein, Heinemeyer, Hendil, Holmberg, Hudson, Husnjak, J. Michael Lord, Jarosch, Jin, Jonathan P. Cook, Kohler, Lam, Li, Li, Lipson, Lundgren, Lynne M. Roberts, May, Mayerhofer, Nishi Vasisht, Paola Pietroni, Rabinovich, Rasmus Hartmann-Petersen, Redmann, Robert A. Spooner, Rubin, Sandvig, Schreiner, Sokolowska, Spooner, Spooner, Spooner, Spooner, Strickland, Surjit, Unno, van Nocker, Wesche, Ye   +61 more
core   +2 more sources