Results 21 to 30 of about 10,421 (212)
Active Immunity Induced by Passive IgG Post-Exposure Protection against Ricin
Toxins, 2014 Therapeutic antibodies can confer an instant protection against biothreat agents when administered. In this study, intact IgG and F(ab’)2 from goat anti-ricin hyperimmune sera were compared for the protection against lethal ricin mediated intoxication ...
Charles Chen Hu +4 more
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Routing of internalized ricin and ricin conjugates to the Golgi complex. [PDF]
The Journal of cell biology, 1986 Receptor-mediated endocytosis and intracellular routing of native ricin, and of ricin conjugated to colloidal gold (Ri-Au) and to horseradish peroxidase (Ri-HRP), have been studied in cultured MCF-7 and Vero cells by electron microscopical techniques including serial section analysis. Both native ricin, as demonstrated by immunoperoxidase cytochemistry,
van Deurs, B. +4 more
openaire +4 more sources
Characterization of Ricin and R. communis Agglutinin Reference Materials
Toxins, 2015 Ricinus communis intoxications have been known for centuries and were attributed to the toxic protein ricin. Due to its toxicity, availability, ease of preparation, and the lack of medical countermeasures, ricin attracted interest as a potential ...
Sylvia Worbs +9 more
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Cargo binding promotes KDEL receptor clustering at the mammalian cell surface [PDF]
Sci. Rep. 6, 28940, 2016, 2017 Transmembrane receptor clustering is a ubiquitous phenomenon in pro- and eukaryotic cells to physically sense receptor/ligand interactions and subsequently translate an exogenous signal into a cellular response. Despite that receptor cluster formation has been described for a wide variety of receptors, ranging from chemotactic receptors in bacteria to ...
arxiv +1 more source
Antibodies, 2013 Ricin is a type II ribosome inactivating protein (RIP) isolated from castor beans. Its high toxicity classifies it as a possible biological weapon. On the other hand, ricin linked to specific monoclonal antibodies or used in other conjugates has powerful
Monika Słomińska-Wojewódzka +1 more
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Immunochromatography Detection of Ricin in Environmental and Biological Samples
Nano Biomedicine and Engineering, 2011 Ricin has been considered as a potential agent of biological warfare or terrorist attack. This work is aimed to develop and evaluate a rapid test strip for the assay of ricin in environmental and biological samples.
Junhua Wu +7 more
doaj +1 more source
Equal Neutralization Potency of Antibodies Raised against Abrin Subunits
Antibodies, 2020 Abrin and ricin are potent AB toxins, which are considered biological threats. To date, there are no approved treatments against abrin or ricin intoxications.
Yoav Gal +9 more
doaj +1 more source
Differential neutralizing activities of a single domain camelid antibody (VHH) specific for ricin toxin's binding subunit (RTB). [PDF]
PLoS ONE, 2014 Ricin, a member of the A-B family of ribosome-inactivating proteins, is classified as a Select Toxin by the Centers for Disease Control and Prevention because of its potential use as a biothreat agent.
Cristina Herrera +4 more
doaj +1 more source
Toxins, 2018 Ricin, a highly lethal toxin derived from the seeds of Ricinus communis (castor beans) is considered a potential biological threat agent due to its high availability, ease of production, and to the lack of any approved medical countermeasure against ...
Reut Falach +11 more
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Targeting ricin to the ribosome [PDF]
Toxicon, 2013 The plant toxin ricin is highly toxic for mammalian cells and is of concern for bioterrorism. Ricin belongs to a family of functionally related toxins, collectively referred to as ribosome inactivating proteins (RIPs), which disable ribosomes and halt protein synthesis. Currently there are no specific antidotes against ricin or related RIPs.
Nilgun E. Tumer, Kerrie L. May, Qing Yan
openaire +3 more sources