Results 161 to 170 of about 113,465 (266)
Exposure to azithromycin and the effect of co-administration of rifampicin in patients with non-tuberculous mycobacterial disease. [PDF]
J Antimicrob ChemotherRodgers MP +7 more
europepmc +1 more source
Alimentary Pharmacology &Therapeutics, Volume 64, Issue 1, Page 23-35, July 2026.Seladelpar improved itch, itch‐related sleep disturbance and measures of fatigue in patients with primary biliary cholangitis and pruritus in the Phase 3 RESPONSE trial. ABSTRACT Background Pruritus and fatigue impose a significant burden on patient quality of life in primary biliary cholangitis (PBC).
Cynthia Levy +10 more
wiley +1 more source
Mavacamten toxicity, hepatic dysfunction, and rifampicin: cause or coincidence? [PDF]
Eur Heart J Case RepMapelli M, Costantino S, Maragna R.
europepmc +1 more source
, 2015 A rapid and sensitive liquid chromatography coupled with tandem mass spectrometry (LC/MS2) method for the simultaneous quantification of rifampicin and its main active metabolite 25-desacetyl rifampicin in human plasma was developed and validated.
VLASE, Laurian +6 more
core
Basic &Clinical Pharmacology &Toxicology, Volume 139, Issue 1, July 2026.ABSTRACT Tramadol is a widely used analgesic whose bioactivation to O‐desmethyltramadol is primarily mediated by cytochrome P450 2D6 (CYP2D6). Genetic variability and drug–drug interactions affecting CYP2D6 may influence tramadol pharmacokinetics and pharmacological effects.
Tuukka Saarikoski +6 more
wiley +1 more source
Machine Learning Accelerates Crystallization for Structure Determination
Angewandte Chemie, Volume 138, Issue 25, 15 June 2026.Single‐crystal X‐ray diffraction (SCXRD) is often constrained by the difficulty of obtaining suitable crystals. Here, a machine learning‐accelerated co‐crystal discovery workflow is established for a crystalline mate strategy that achieves over 95% prediction accuracy and experimentally delivers 114 co‐crystals from 120 candidates.
Cui‐Zhou Luan +10 more
wiley +2 more sources
Effects of bulevirtide on atherosclerosis in an ApoE-deficient mouse model. [PDF]
PLoS OneRusnak J +5 more
europepmc +1 more source
Clinical and Translational Science, Volume 19, Issue 7, July 2026.ABSTRACT Multiple sclerosis (MS) is a significant cause of neurological disability in young adults. Siponimod, a potent sphingosine‐1‐phosphate (S1P) receptor modulator, is used to treat MS by reducing T‐cell recirculation and central inflammation. The presented work includes clinical data describing the impact of the CYP3A4 inhibitor clarithromycin on
Felix Huth +6 more
wiley +1 more source
Stereoselective Biotransformation: Transfer of Learning to Advance Drug Metabolism and Biocatalysis
Angewandte Chemie, Volume 138, Issue 25, 15 June 2026.Understanding stereoselective biotransformations has implications for predicting drug disposition and response and may also inspire novel biocatalytic and biomimetic strategies to address challenges in metabolite and API synthesis. ABSTRACT Chirality is an important determinant of drug action, as enantiomers can exhibit markedly different ...
Grace A. Okunlola, Godwin A. Aleku
wiley +2 more sources