Results 161 to 170 of about 157,428 (296)

Evaluation of in vitro toxicity of common phytochemicals included in weight loss supplements using 1H NMR spectroscopy

FEBS Open Bio, Volume 16, Issue 5, Page 906-920, May 2026.
We investigated the toxicity of 12 active compounds commonly found in herbal weight loss supplements (WLS) using human liver and colon cell models. Epigallocatechin‐3‐gallate was the only compound showing significant toxicity. Metabolic profiling revealed protein degradation, disrupted energy and lipid metabolism suggesting that the inclusion of EGCG ...
Emily C. Davies, Garth L. Maker, Ian F. Musgrave, Samantha Lodge   +3 more
wiley   +1 more source

Bedaquiline resistance in patients with Xpert MTB/RIF Ultra-tested rifampicin-resistant tuberculosis in the Western Cape, South Africa: a prospective study. [PDF]

Lancet Microbe
Steyn J, Williams J, Naufal F, Limberis J, Grobbelaar M, Ismail N, Ghebrekristos Y, Opperman CJ, Nalyvayko A, Singh S, Colman RE, Rodwell TC, Theron G, Warren RM, Metcalfe JZ.   +14 more
europepmc   +1 more source

Discovery of H2 Receptor Antagonists as Colistin Enhancers by Targeting Acid Stress Response

Advanced Science, Volume 13, Issue 26, 8 May 2026.
This study identifies YqgB as a key target for restoring colistin susceptibility in mcr‐positive pathogens under acidic conditions by remodeling phospholipid composition and reducing LPS modification. Deep learning‐based screening reveals H2 receptor antagonists as novel colistin adjuvants. Further investigations indicate that ranitidine and famotidine
Jinju Cai, Mengping He, Jianya Luo, Shuang Zhou, Tengyue Zhang, Jianing Li, Zhiqiang Wang, Yuan Liu   +7 more
wiley   +1 more source

Comparative evaluation of sputum microscopy and Xpert MTB/RIF assay for tuberculosis detection and rifampicin resistance surveillance in Biratnagar, Nepal. [PDF]

Microbiol Spectr
Ojha S, Adhikari A, Adhikari S, Khanal S, Kalwar CS, Panta OP.   +5 more
europepmc   +1 more source

Quality by Design‐Based Development of a Robust LC Method for Simultaneous Estimation of Process‐ and Degradation‐Related Impurities in Rifapentine Drug Product for the Treatment of Active and Latent Tuberculosis

Biomedical Chromatography, Volume 40, Issue 5, May 2026.
ABSTRACT A precise, robust, and stability‐indicating liquid chromatographic (LC) method coupled with a photodiode array (PDA) detector was developed and validated for the quantitative estimation of rifapentine, an essential therapeutic agent for both active and latent tuberculosis (TB).
Siva Prasad Korikana, Sreenivasa Rao Battula, Naresh Konduru, Aravind Kurnool, Divya Kumar Vemuri, Venkata Lakshamana Sagar Dantinapalli   +5 more
wiley   +1 more source

Rapid Identification of Drug-Resistant Strains of Mycobacterium leprae through qPCR High-Resolution Melt Analysis (HRMA): A High-Throughput and Effective Screening Method. [PDF]

Indian Dermatol Online J
Sharma R, Singh I, Gupta S.
europepmc   +1 more source

Safe Reconstruction of Posterior Sternoclavicular Dislocation Using a Palmaris Longus Autograft and ACL Tibial Guide Assistance: A Case Report

Clinical Case Reports, Volume 14, Issue 5, May 2026.
Use of an ACL tibial guide enables precise and safe tunnel placement during figure‐of‐eight reconstruction for posterior sternoclavicular joint dislocation, reducing the risk of mediastinal injury while restoring joint stability. ABSTRACT Posterior sternoclavicular joint (SCJ) dislocation is an uncommon but clinically significant injury due to its ...
Bilgehan Ocak, Süleyman Kaan Öner, Arda Bilir, Nihat Demirhan Demirkiran   +3 more
wiley   +1 more source

Landouzy sepsis in a young adult with multiorgan failure: successful ECMO-assisted management using an individualized antituberculous regimen. [PDF]

BMC Infect Dis
van de Sand L, Dubler S, Bertram S, Aulenkamp JL, Pirschtat NV, Witzke O, Hegerfeldt Y, Zettler M.   +7 more
europepmc   +1 more source

Systematic Management of a Critical CYP3A4 Interaction Between Cabozantinib and Carbamazepine: A Case Report of a Clinically Relevant Pharmacokinetic Interaction

Clinical Case Reports, Volume 14, Issue 5, May 2026.
ABSTRACT This was the case of a 62‐year‐old patient treated with cabozantinib and nivolumab for metastatic clear cell renal cell carcinoma, in whom a clinically significant pharmacokinetic interaction with carbamazepine was observed. Carbamazepine, a potent inducer of CYP3A4, caused a major decrease in systemic exposure to cabozantinib, as confirmed by
Pierre Nizet, Jean‐François Huon, Caroline Viala, Siméon Robin, Wala Ammor   +4 more
wiley   +1 more source

Pattern and prevalence of rifampicin and isoniazid-resistant tuberculosis using genotype MTBDR<i>plus</i> assay in Ethiopia. [PDF]

Microbiol Spectr
Getahun M, Ameni G, Mollalign H, Diriba G, Beyene D.   +4 more
europepmc   +1 more source