Results 181 to 190 of about 121,575 (281)

Evaluating the Impact of CYP1A2 Inhibition on the Pharmacokinetics of Savolitinib: A Phase 1 Open‐Label Study

Pharmacology Research &Perspectives, Volume 14, Issue 5, October 2026.
ABSTRACT Savolitinib is an oral, potent, selective CNS‐penetrant MET‐tyrosine kinase inhibitor that in vitro studies indicate is metabolized by cytochrome P450 (CYP) enzymes, including CYP1A2, and by non‐CYP enzymes, such as aldehyde oxidase (AO). Savolitinib primary metabolites, M2 and M3, are formed mainly by CYP1A2 and AO, respectively. This Phase 1,
Kowser Miah, Jitendar Reddy, Pradeep Sharma, Ike Igwegbe, Simon Nelson, Caitlin Muldoon, Ronald Goldwater, Karthick Vishwanathan   +7 more
wiley   +1 more source

Clinical Utility of Cartridge-Based Nucleic Acid Amplification Test for Tuberculosis and Rifampicin Resistance Detection in the Vindhya Region of India: A Retrospective Study. [PDF]

Cureus
Agrawal RP, Sinha A, Chaubey P, Akhani PN.   +3 more
europepmc   +1 more source

Population Pharmacokinetics of Dolutegravir in Plasma and Cerebrospinal Fluid in Adults Living With HIV

CPT: Pharmacometrics &Systems Pharmacology, Volume 15, Issue 10, October 2026.
ABSTRACT Characterizing dolutegravir penetration into the central nervous system is important for optimizing human immunodeficiency virus treatment outcomes, yet population‐specific pharmacokinetic data describing cerebrospinal fluid disposition and equilibration kinetics remain lacking.
Mohammed W. Ali, Sam Nightingale, Tracy Kellermann, John Joska, Alan Winston, Saye Khoo, Joseph F. Standing, Eric H. Decloedt, Ahmed A. Abulfathi   +8 more
wiley   +1 more source

A case report of acute kidney injury due to the use of rifampicin in <i>Brucella</i> induced spondylodiscitis. [PDF]

IDCases
Bakar L, Yağcı Çağlayık D.
europepmc   +1 more source

Application of an Open‐Source Modular Framework for Pharmacokinetic, Pharmacodynamic, and Safety Simulations to Anti‐Tuberculosis Drugs

CPT: Pharmacometrics &Systems Pharmacology, Volume 15, Issue 10, October 2026.
ABSTRACT Tuberculosis (TB) treatment requires long‐term multidrug regimens where dosing, efficacy, and safety optimization remain challenging. This tutorial establishes an integrated, open‐source, modular framework connecting high‐throughput PBPK (HT‐PBPK) simulations, mechanistic PBPK models, pharmacodynamic endpoints, and safety predictions for anti ...
Marco Siccardi, Nina Nauwelaerts, Raphaëlle Lesage, Diane Lefaudeux, Vanessa Baier, Venetia Karamitsou, Cleo Demeester, Miao‐Chan Huang, Alexander Kulesza, Stephan Schaller   +9 more
wiley   +1 more source

From mutation detection to treatment decisions: CRISPR-enabled diagnostics for drug-resistant tuberculosis. [PDF]

Front Bioeng Biotechnol
Yi W, Luo F, Yi D, Guo J, Liu S, Yan Q, Luo H.   +6 more
europepmc   +1 more source

The Proteome of Plasma Extracellular Vesicles in Latent and Active Tuberculosis Reveals Phase‐Specific Composition and Immunometabolic Insights

FASEB BioAdvances, Volume 8, Issue 10, October 2026.
Plasma extracellular vesicles (EVs) from individuals with latent (LTB) or active tuberculosis (ATB) exhibit distinct proteomic compositions, reflecting the underlying immunometabolic states of each phase. In LTB, EVs are enriched in proteins associated with tissue remodeling and lipid metabolism, including TGFβ, APOA1, and APOE, which may participate ...
Eliud S.‐Peregrino, Jessica Castañeda‐Casimiro, Luis Vallejo‐Castillo, Mishelle Soria‐Fragoso, Gloria M. Ortega‐Díaz, Karen I. Mondragón‐Lara, Alfonso Méndez‐Tenorio, Rommel Chacón‐Salinas, Blanca E. García‐Pérez, Jeanet Serafín‐López, Carlos Wong‐Baeza, Víctor Hugo Rosales‐García, Alejandro Hernández‐Solis, Isabel Wong‐Baeza   +13 more
wiley   +1 more source

Coproporphyrin I PBPK model in the open systems pharmacology suite enables precise prediction of OATP 1B- mediated drug interactions through calibrated <i>In vivo</i> inhibition constants. [PDF]

Front Pharmacol
Kanacher T, Pellowe M, Kovar C, Eriksson J, Wu J, Busse D, Gómez-Mantilla JD, Stopfer P, Ince I, Huang F.   +9 more
europepmc   +1 more source

Metagenomic Characterisation of Antibiotic Resistance in Anaerobic Digesters and Their Implications for Environmental Health

Environmental Microbiology Reports, Volume 18, Issue 5, October 2026.
Anaerobic digester metagenomes revealed diverse resistance‐associated annotations and antibiotic target loci, highlighting their potential role in environmental AMR surveillance. The findings emphasise the need for cautious interpretation of resistome profiles and further host‐resolved analyses to determine the mobility and clinical relevance of ...
Olasunbo Aina Olasupo, Oluwaseyi Paul Olaniyan, Sunday Babatunde Akinde, Ademola Ayodele Adesoye, Fatimah Adenike Ajadi, Omokaro Obire, Elijah Kolawole Oladipo, Waidi Folorunso Sule, Olamilekan Emmanuel Oyinloye, Adedolapo Aishat Salami, Emmanuel Sunday Fajoyegbe, Adejoke Janet Ajani, Olabisi Ojo   +12 more
wiley   +1 more source

Partial Oral Antibiotic Therapy for Infective Endocarditis: A Practical Review of Current Evidence and Guidelines. [PDF]

Pathogens
Roland T, Yombi JC.
europepmc   +1 more source