Results 181 to 190 of about 113,465 (266)

HflX mediates rifampicin resistance in <i>Brucella</i> by downregulating the expression of RNA polymerase-associated genes. [PDF]

Front Microbiol
Geng H, Qi M, Su M, Zhi F, Chu Y.
europepmc   +1 more source

Optimisation of a Novel Class of DNA Gyrase Inhibitors to Improve Antibacterial Activity

ChemMedChem, Volume 21, Issue 11, 15 June 2026.
This article describes efforts to increase the antibacterial activity of a recently reported class of novel DNA gyrase inhibitors known as the isoquinoline sulphonamides by improving their uptake in bacterial cells. As antibiotic resistance continues to rise, the need for new antibacterials is clear.
Meg I. Ferguson, Cerissa C. van Walstijn, Vladyslav Lysenko, Marta A. Wilbrink, David Alencar Araripe, Jeroen M. Punt, Mario van der Stelt, Willem Jespers, Paolo Innocenti, Nathaniel I. Martin   +9 more
wiley   +1 more source

Comment on "Prevalence and risk factors associated with rifampicin-induced cholestasis jaundice among tuberculosis patients in high-incidence setting: A retrospective cohort study". [PDF]

J Clin Tuberc Other Mycobact Dis
Yu Y.
europepmc   +1 more source

Insights into the Role of Rifampicin Exposure and Clinical Baseline Covariates on the Response to Pulmonary Tuberculosis Treatment. [PDF]

Clin Infect Dis
Wijk M, Denti P, Gausi K, Myers B, Carney T, White LF, Theron D, Parry CDH, Horsburgh CR, Rawoot N, Warren RM, Court R, Kulkarni SG, Farhat MR, Buys C, Malatesta S, Weber SE, Kulkarni S, McIlleron H, Jacobson KR, Kloprogge F.   +20 more
europepmc   +1 more source

Uridine diphosphate glucuronosyltransferase 1A1 gene polymorphisms and treatment outcomes in HIV and MTB coinfection in sub-Saharan Africa: a scoping review protocol. [PDF]

BMJ Open
Vhanda D, Musarurwa C, Chikwati RP, Muziringa M, Dandara C, Manasa J, Chirenda J, Mavenyengwa RT.   +7 more
europepmc   +1 more source

Impact of High-Dose Rifampicin on Linezolid Pharmacokinetics in Tuberculous Meningitis. [PDF]

Open Forum Infect Dis
Purohit D, van Wijk R, Kafeero P, Kibengo F, Zimmerman M, D'artois V, Chow FC, Savic RM.   +7 more
europepmc   +1 more source

Rifabutin boosts rifampicin accumulation in THP-1-derived M2 macrophages by inhibiting P-glycoprotein efflux activity. [PDF]

Arch Toxicol
Hamburg K, Bay C, Burhenne J, Weiss J, Stingl JC, Theile D.   +5 more
europepmc   +1 more source

Pharmacokinetics of Twice-daily Tenofovir Alafenamide in Adults With HIV-associated Tuberculosis on Bictegravir/Emtricitabine/Tenofovir Alafenamide and Rifampicin. [PDF]

Clin Infect Dis
Osuala EC, Nkuhairwe IN, Letsoalo MP, Naidoo K, Perumal R, Rooney JF, Wiesner L, Wasmann RE, Denti P, Dooley KE, Naidoo A, INSIGHT Study Team .   +11 more
europepmc   +1 more source

Population Pharmacokinetic Modeling of Standard- and High-Dose Rifampicin for Tuberculosis Preventive Therapy in the 2R2 Randomized Controlled Trial. [PDF]

J Infect Dis
Gafar F, Svensson EM, Yunivita V, Fregonese F, Fisher D, Fox GJ, Nguyen TA, Nguyen BH, Johnston J, Long R, Valiquette C, Aarnoutse RE, Ruslami R, Menzies D.   +13 more
europepmc   +1 more source

Real-time bioluminescence imaging of mycobacteria with Akaluc: a novel method for monitoring drug efficacy. [PDF]

Sci Rep
Islam MS, Takeishi A, Tateishi Y, Nishiyama A, Ozeki Y, Yoshida Y, Shaban AK, Annoura T, Iwano S, Fukuhara T, Matsumoto S.   +10 more
europepmc   +1 more source