Results 11 to 20 of about 191,709 (318)

High-dose rifampicin in tuberculosis: Experiences from a Dutch tuberculosis centre.

PLoS ONE, 2019
BackgroundRecent evidence suggests that higher rifampicin doses may improve tuberculosis (TB) treatment outcome.MethodsIn this observational cohort study we evaluated all TB patients who were treated with high-dose rifampicin (> 10 mg/kg daily) in our ...
Charlotte Seijger, Wouter Hoefsloot, Inge Bergsma-de Guchteneire, Lindsey Te Brake, Jakko van Ingen, Saskia Kuipers, Reinout van Crevel, Rob Aarnoutse, Martin Boeree, Cecile Magis-Escurra   +9 more
doaj   +2 more sources

Oligomer-Targeting Prevention of Neurodegenerative Dementia by Intranasal Rifampicin and Resveratrol Combination – A Preclinical Study in Model Mice

Frontiers in Neuroscience, 2021
Amyloidogenic protein oligomers are thought to play an important role in the pathogenesis of neurodegenerative dementia, including Alzheimer’s disease, frontotemporal dementia, and dementia with Lewy bodies.
Tomohiro Umeda, Ayumi Sakai, Keiko Shigemori, Ayumi Yokota, Toru Kumagai, Takami Tomiyama, Takami Tomiyama   +6 more
doaj   +2 more sources

Green synthesis of copper oxide nanoparticles and its efficiency in degradation of rifampicin antibiotic

Scientific Reports, 2023
In recent ages, green nanotechnology has gained attraction in the synthesis of metallic nanoparticles due to their cost-effectiveness, simple preparation steps, and environmentally-friendly. In the present study, copper oxide nanoparticles (CuO NPs) were
D. Nzilu, E. Madivoli, D. Makhanu, S. Wanakai, Gideon Kirui Kiprono, P. Kareru   +5 more
semanticscholar   +1 more source

Xpert MTB/RIF Ultra and Xpert MTB/RIF assays for extrapulmonary tuberculosis and rifampicin resistance in adults

Cochrane Database of Systematic Reviews, 2021
Background Xpert MTB/RIF Ultra (Xpert Ultra) and Xpert MTB/RIF are World Health Organization (WHO)‐recommended rapid nucleic acid amplification tests (NAATs) widely used for simultaneous detection of Mycobacterium tuberculosis complex and rifampicin ...
Mikashmi Kohli, Ian Schiller, N. Dendukuri, M. Yao, K. Dheda, C. Denkinger, S. Schumacher, K. Steingart   +7 more
semanticscholar   +1 more source

Xpert Ultra versus Xpert MTB/RIF for pulmonary tuberculosis and rifampicin resistance in adults with presumptive pulmonary tuberculosis

Cochrane Database of Systematic Reviews, 2021
Background Xpert MTB/RIF and Xpert MTB/RIF Ultra (Xpert Ultra) are World Health Organization (WHO)‐recommended rapid tests that simultaneously detect tuberculosis and rifampicin resistance in people with signs and symptoms of tuberculosis.
Jerry S Zifodya, J. Kreniske, Ian Schiller, Mikashmi Kohli, N. Dendukuri, S. Schumacher, E. Ochodo, F. Haraka, A. Zwerling, M. Pai, K. Steingart, D. Horne   +11 more
semanticscholar   +1 more source

JMM profile: rifampicin: a broad-spectrum antibiotic.

Journal of Medical Microbiology, 2022
Rifampicin (also known as rifampin) inhibits RNA synthesis, and is used to treat tuberculosis, leprosy, staphylococcal infections and legionnaires’ disease.
K. Hardie, S. Fenn
semanticscholar   +1 more source

Involvement of endoplasmic reticulum stress in rifampicin-induced liver injury

Frontiers in Pharmacology, 2022
Rifampicin is a first-line antituberculosis drug. Hepatocyte toxicity caused by rifampicin is a significant clinical problem. However, the specific mechanism by which rifampicin causes liver injury is still poorly understood.
Wanqing Hou, Bernard Nsengimana, Chuyun Yan, B. Nashan, Shuxin Han   +4 more
semanticscholar   +1 more source

A review of formulations and preclinical studies of inhaled rifampicin for its clinical translation

Drug Delivery and Translational Research, 2022
Inhaled drug delivery is a promising approach to achieving high lung drug concentrations to facilitate efficient treatment of tuberculosis (TB) and to reduce the overall duration of treatment. Rifampicin is a good candidate for delivery via the pulmonary
Prakash Khadka, J. Dummer, P. Hill, R. Katare, Shyamal C. Das   +4 more
semanticscholar   +1 more source

Outcome of Debridement, Antibiotics, and Implant Retention for Staphylococcal Hip and Knee Prosthetic Joint Infections, Focused on Rifampicin Use: A Systematic Review and Meta-Analysis

Open Forum Infectious Diseases, 2021
The treatment of staphylococcal prosthetic joint infection (PJI) with debridement, antibiotics, and retention of the implant (DAIR) often results in failure. An important evidence gap concerns the treatment with rifampicin for PJI.
H. Scheper, Maxime Gerritsen, B. Pijls, Suzanne Van Asten, Leo Visser, M. D. de Boer   +5 more
semanticscholar   +1 more source

High-Dose Oral and Intravenous Rifampicin for the Treatment of Tuberculous Meningitis in Predominantly Human Immunodeficiency Virus (HIV)-Positive Ugandan Adults: A Phase II Open-Label Randomized Controlled Trial

Clinical Infectious Diseases, 2021
Background High-dose rifampicin may improve outcomes of tuberculous meningitis (TBM). Little safety or pharmacokinetic (PK) data exist on high-dose rifampicin in human immunodeficiency virus (HIV) coinfection, and no cerebrospinal fluid (CSF) PK data ...
F. Cresswell, D. Meya, E. Kagimu, D. Grint, L. T. Te Brake, J. Kasibante, E. Martyn, M. Rutakingirwa, C. Quinn, M. Okirwoth, L. Tugume, Kenneth Ssembambulidde, A. Musubire, A. Bangdiwala, Allan Buzibye, C. Muzoora, E. Svensson, R. Aarnoutse, D. Boulware, A. Elliott   +19 more
semanticscholar   +1 more source