Results 51 to 60 of about 157,428 (296)

The MarR-Type Repressor MhqR Confers Quinone and Antimicrobial Resistance in Staphylococcus aureus [PDF]

, 2019
Aims: Quinone compounds are electron carriers and have antimicrobial and toxic properties due to their mode of actions as electrophiles and oxidants.
Fritsch, Verena Nadin, Loi, Vu Van, Busche, Tobias, Sommer, Anna, Tedin, Karsten, Nürnberg, Dennis J., Kalinowski, Jörn, Bernhardt, Jörg, Fulde, Marcus, Antelmann, Haike   +9 more
core   +1 more source

Transposase‐Assisted Donor Tethering Boosts Large‐Fragment HDR in Plants

Advanced Science, EarlyView.
A transposase‐assisted donor tethering strategy is developed to enhance homology‐directed repair in plants. By recruiting donor DNA to double‐strand breaks and synergizing with repair pathway reprogramming and transcription‐coupled donor design, this system markedly improves large‐fragment targeted insertion efficiency, providing a robust platform for ...
Sha Wei, Kai Zhang, Shuke Deng, Jinjie Chen, Xiaomei Huang, Jingfei Guo, Yuqing Wu, Yingjie Guo, Zhen Liang   +8 more
wiley   +1 more source

Crystal violet decolorization assay for rapid detection of multidrug-resistant Mycobacterium tuberculosis isolates: A multicenter study

International Journal of Mycobacteriology, 2018
Background: Effective control of tuberculosis is achieved by early diagnosis and drug susceptibility testing for initiation of appropriate treatment.
Ahmet Yilmaz Coban, Gumral Alakbarova, Luqman Satti, Nadia Tayyab, Gohar Zaman, Nora Morcillo, Belen Imperiale, Ingrid Wainmayer, Norberto Simboli   +8 more
doaj   +1 more source

Comparison of oral propranolol, oral rifampicin, and intravitreal anti-VEGF in central serous chorioretinopathy

Indian Journal of Ophthalmology, 2023
Purpose: To compare the efficacy of oral propranolol, oral rifampicin, and intravitreal anti-VEGF therapies on resolution-time and visual outcome in patients with central serous chorioretinopathy (CSCR).
K Sandeep, Kavitha C Venugopal, Akshatha P Javagal, Pavana Acharya, S R Sreelekshmi, N Narendra, P K Nayana   +6 more
doaj   +1 more source

Adverse drug reactions in tuberculosis patients due to directly observed treatment strategy therapy: Experience at an outpatient clinic of a teaching hospital in the city of Imphal, Manipur, India

The Journal of Association of Chest Physicians, 2013
Background: As to the profile of adverse drug reactions (ADRs) due to directly observed treatment, short course (DOTS), there is no report available in patients receiving antituberculosis (anti-TB) chemotherapy in Manipur, India.
Kumarjit Sinha, Izora Trudy R Marak, W Asoka Singh   +2 more
doaj   +1 more source

Antisense PNA accumulates in Escherichia coli and mediates a long post-antibiotic effect [PDF]

, 2007
Antisense agents that target growth-essential genes display surprisingly potent bactericidal properties. In particular, peptide nucleic acid (PNA) and phosphorodiamidate morpholino oligomers linked to cationic carrier peptides are effective in time kill ...
Behmanesh, Mehrdad, Dryselius, Rikard, Faridani, Omid R, Ganyu, Anita, Goh, Shan, Good, Liam, Klok, Erik Jan, Nikravesh, Abbas, Sadeghizadeh, Majid, Zain, Rula   +9 more
core   +2 more sources

Oligomer-Targeting Prevention of Neurodegenerative Dementia by Intranasal Rifampicin and Resveratrol Combination – A Preclinical Study in Model Mice

Frontiers in Neuroscience, 2021
Amyloidogenic protein oligomers are thought to play an important role in the pathogenesis of neurodegenerative dementia, including Alzheimer’s disease, frontotemporal dementia, and dementia with Lewy bodies.
Tomohiro Umeda, Ayumi Sakai, Keiko Shigemori, Ayumi Yokota, Toru Kumagai, Takami Tomiyama, Takami Tomiyama   +6 more
doaj   +1 more source

Use of Dispersible Fixed-Dose Combinations in Chemotherapy of Drug Susceptible Tuberculosis: Results of the Observational Study

Туберкулез и болезни лёгких
The objective: to assess effectiveness, safety and pharmacoeconomic feasibility of using a dispersible fixed-dose combination (isoniazid 150 mg, rifampicin 150 mg, pyrazinamide 375 mg) in patients with respiratory tuberculosis and preserved ...
E. S. Nikitina, O. S. Ilyina, O. D. Baronova   +2 more
doaj   +1 more source

Population pharmacokinetics of levofloxacin in breastmilk in patients with rifampicin‐resistant tuberculosis

British Journal of Clinical Pharmacology, EarlyView.
Levofloxacin is a widely used antibiotic included in rifampicin‐resistant tuberculosis (RR‐TB) treatment. Data describing levofloxacin concentrations in breastmilk and infant exposure are limited. We analysed data from two South African studies of breastfeeding women receiving levofloxacin (750–1000 mg daily) for RR‐TB.
Sharon Sawe, Lufina Tsirizani, Buyisile Mkhize, Lubbe Wiesner, Gary Maartens, Francesca Conradie, Richard Court, Marian Loveday, Catriona Waitt, Paolo Denti   +9 more
wiley   +1 more source

Early Administration of Rifampicin Does Not Induce Increased Resistance in Septic Two-Stage Revision Knee and Hip Arthroplasty

Antibiotics
Background/Objectives: Periprosthetic joint infection (PJI) is a severe complication that follows arthroplasty and occurs in approximately 2% of all cases. One of several cornerstones of therapy is an optimized antibiotic regimen. Early administration of
Leonard Grünwald, Benedikt Paul Blersch, Bernd Fink   +2 more
doaj   +1 more source