Results 111 to 120 of about 97,638 (260)

Single strand conformation polymorphism profiles with biotinylated PCR products to detect mutations in rpoB gene of Mycobacterium tuberculosis [PDF]

, 1997
A fragment of the rpoB gene, including the region shown to be involved in rifampicin resistance, was amplified from 15 rifampicin-resistant and 6 rifampicin- sensitive clinical isolates of Mycobacterium tuberculosis by the polymerase chain reaction ...
McNerney, R, Narayanan, P R, Selvakumar, N, Wilson, S M   +3 more
core  

Rifampicin curing of plasmids in Escherichia coli K12−rifampicin resistant host

Journal of Pharmacy and Pharmacology, 1984
Abstract The in-vitro rifampicin curing of R-plasmids JR225, BN102, BN106 and F’-plasmid F’lac+/R386 in Escherichia coli K12 rifampicin-resistant host J62–2 is described. The minimum rifampicin curing concentration and the frequency of curing of plasmids from the rifampicin-resistant host cell J62–2 and the isogenic rifampicin-sensitive ...
openaire   +2 more sources

Reduced fecundity associated with Wolbachia infection in a Neotropical drosophilid Redução da fecundidade associada à infecção por Wolbachia em um drosofilídeo Neotropical

Ecological Entomology, EarlyView.
Using multiple infected and uninfected Drosophila sturtevanti lines, we investigated (i) the impact of Wolbachia on fecundity and (ii) its effects relative to antibiotic treatment. Based on over 1680 dissected ovaries, fecundity was similar between infected and uninfected flies.
Letícia Carlesso de Paula Sena, Marina Magalhães Moreira, Luísa de Paula Bouzada Dias, Jhonny José Magalhães Guedes, Karla Suemy Clemente Yotoko   +4 more
wiley   +1 more source

Susceptibility Profiles of Mycobacterium ulcerans Isolates to Streptomycin and Rifampicin in Two Districts of the Eastern Region of Ghana

International Journal of Microbiology, 2016
Background. Drug resistance is a major challenge in antibiotic chemotherapy. Assessing resistance profiles of pathogens constitutes an essential surveillance tool in the epidemiology and control of infectious diseases, including Buruli ulcer (BU) disease.
Enid Owusu, Mercy Jemima Newman, Nana Konama Kotey, Amos Akumwena, Elizabeth Bannerman   +4 more
doaj   +1 more source

Review of multidrug-resistant and extensively drug-resistant TB: global perspectives with a focus on sub-Saharan Africa [PDF]

, 2010
Tuberculosis (TB) remains a global emergency and is responsible for 1.7 million deaths annually. Widespread global misuse of isoniazid and rifampicin over three decades has resulted in emergence of the ominous spread of multidrug-resistant TB (MDR-TB ...
Abdool Karim, Amor, Balabanova, Caminero, Centers for Disease Control and Prevention, Chan, Chiang, Chiang, Chiang, Churchyard, Dheda, Dravniece, Dubrovina, Elliott, Espinal, Espinal, Espinal, Flament-Saillour, Gandhi, Gandhi, Gandhi, Goble, Grobusch, Habeenzu, Hoek, Holtz, Holtz, Iseman, Johnson, Kehinde, Kim, Kingkaew, Korenromp, Kranzer, Lalloo, Laserson, Lienhardt, Ma, Martin, Matteelli, Meskel, Migliori, Migliori, Migliori, Migliori, Migliori, Moore, Motus, O’Donnell, Pablos-Méndez, Pai, Park, Pietzka, Pillay, Quy, Saravia, Schaaf, Schaaf, Shah, Somocurcio, Sonnenberg, Sotgiu, Torun, Umubyeyi, Wallis, WHO, WHO, WHO and IUATLD, Wright, Wright, Zumla   +70 more
core   +1 more source

Hierarchical analysis of unsuccessful tuberculosis treatment among people living with HIV in Brazil using nationwide surveillance data

HIV Medicine, EarlyView.
Abstract Introduction People with tuberculosis‐HIV coinfection face multiple barriers to effective treatment, including social vulnerability, stigma and limited access to healthcare. This study examined factors associated with loss to follow‐up and death among individuals with tuberculosis‐HIV in Brazil.
Lucas Vinícius de Lima, Gabriel Pavinati, Francisco Beraldi‐Magalhães, Rubia Laine de Paula Andrade‐Gonçalves, Aline Aparecida Monroe, Marcela Demitto Furtado, Rosana Rosseto de Oliveira, Daniele Maria Pelissari, Kleydson Bonfim Andrade Alves, Gabriela Tavares Magnabosco   +9 more
wiley   +1 more source

Undetected rifampicin-resistant tuberculosis associated with rpoB I491F and V170F mutations in Botswana: Diagnostic implications

Journal of Global Antimicrobial Resistance
Background: Undetected rifampicin resistance is a threat to global tuberculosis (TB) control efforts by delaying effective treatment. In different studies, non-canonical rpoB mutations outside the rifampicin resistance-determining region have been ...
Tuelo Mogashoa, Justice T. Ngom, Johannes Loubser, Kedumetse Seru, Tuduetso Molefi, One Stephen, Rosemary M. Musonda, Simani Gaseitsiwe, Robin M. Warren, Anzaan Dippenaar, Elizabeth M. Streicher, Sikhulile Moyo   +11 more
doaj   +1 more source

Targeting the hard to reach: Challenges and novel strategies in the treatment of intracellular bacterial infections: Targeting intracellular bacteria [PDF]

, 2016
Infectious diseases continue to threaten human and animal health and welfare globally, impacting millions of lives and causing substantial economic loss. The use of antibacterials has been only partially successful in reducing disease impact.
Good, L, Kamaruzzaman, N F, Kendall, S L
core   +1 more source

Coupling of both a transactivation module and a double‐stranded DNA‐binding domain boosts Cas12i3 variant‐based cytosine and adenine editing in plants

Journal of Integrative Plant Biology, EarlyView.
Fusions of a transactivation module and a double‐stranded DNA‐binding domain produced effective Cas12i3 variant‐based cytosine and adenine base editors, with improved C‐to‐T and A‐to‐G base editing efficiency and expanded editing window. Generated herbicide‐resistant rice germplasm by using these base editors demonstrates their potential for precise ...
Chen Zhang, Jingying Li, Yucai Li, Lei Yan, Christina Seok Yien Yong, Shaoya Li, Yubing He, Lanqin Xia   +7 more
wiley   +1 more source

Rapid Identification of Drug-Resistant Strains of Mycobacterium leprae through qPCR High-Resolution Melt Analysis (HRMA): A High-Throughput and Effective Screening Method

Indian Dermatology Online Journal
Background: Rapid detection of drug-resistant Mycobacterium leprae is essential for effective treatment. Real-time polymerase chain reaction high-resolution melt (qPCR–HRM) analysis is a promising tool for this purpose.
Rahul Sharma, Itu Singh, Saurabh Gupta
doaj   +1 more source