Results 101 to 110 of about 2,415,366 (239)

Pathogenesis of hidradenitis suppurativa: From susceptibility to chronicity

Journal of the European Academy of Dermatology and Venereology, EarlyView.
This review describes hidradenitis suppurativa as a heterogeneous disorder in which genetic susceptibility, epithelial dysfunction, environmental exposures, immune activation and microbial ecology converge differently across patients and disease stages.
Kelsey R. van Straalen, Nisha S. Chandran, Jean M. Fletcher, Evangelos J. Giamarellos‐Bourboulis, Elia Rosi, Gregor B. E. Jemec   +5 more
wiley   +1 more source

Bedaquiline Resistance and Molecular Characterization of Rifampicin-Resistant Mycobacterium Tuberculosis Isolates in Zhejiang, China

, 2023
Enyu Tong,1,* Ying Zhou,1,* Zhengwei Liu,2 Yelei Zhu,2 Mingwu Zhang,2 Kunyang Wu,2 Junhang Pan,2 Jianmin Jiang1– 3 1School of Public Health, Hangzhou Normal University, Hangzhou, 311100, People’s Republic of China; 2Tuberculosis Control ...
Wu K, Jiang J, Liu Z, Pan J, Zhu Y, Zhang M, Zhou Y, Tong E   +7 more
core  

Next Generation Smart Implant Surfaces: Engineering Multifunctional Antimicrobial, Immunomodulatory and Regenerative Interfaces

Journal of Periodontal Research, EarlyView.
Natural‐inspired nano‐textured implant surfaces can be functionalised to modulate macrophage polarisation and local immune responses. This bioactive control promotes improved tissue integration and healing outcomes. ABSTRACT Dental implants rely on a stable and functional interface between the implant surface, surrounding tissues, and the oral ...
Roberto S. Pessoa, Lauren E. Steele, Mehvish Mumtaz, Denver P. Linklater, Neil M. O'Brien‐Simpson, Vladimir Baulin, Peter Kingshott, Roy Judge, Alastair J. Sloan, Elena P. Ivanova   +9 more
wiley   +1 more source

The Hna Phage Defence Protein: A DNA‐Stimulated Helicase With Cryptic Nuclease Activity

Molecular Microbiology, EarlyView.
The Hna (Helicase‐nuclease Abi) phage defence system consists of a single protein and provides defence through abortive infection. We show that Hna's abortive infection response can be recreated in a heterologous host upon expression of phage single‐stranded DNA binding protein (SSB) and present a characterization of Hna's biochemical activity.
Leah M. Sather, Maryam Zamani, Sara N. Andres, Turlough M. Finan   +3 more
wiley   +1 more source

Significant rifampicin resistance mutations identified in the present analysis are located within the rifampicin resistance-determining region (RRDR) of the rpoB gene.

Significant rifampicin resistance mutations identified in the present analysis are located within the rifampicin resistance-determining region (RRDR) of the rpoB gene.
George Priya Doss C (8653101), Athira Thankamani (24376012), Biji C L (24376015)   +2 more
core   +1 more source

Elevated CO2 drives nonlinear trait responses and reshapes growth‐virulence trade‐offs in a plant pathogen

New Phytologist, EarlyView.
Temporal variation in carbon dioxide concentration within the crop canopy and in the atmosphere. Summary Atmospheric CO2 is rising at unprecedented rates. While its physiological effects on plants are well‐documented, the direct evolutionary impact on plant pathogens remains unknown. We investigated how CO2 interacts with other abiotic factors to shape
Li‐Na Yang, Hao Liu, Meng Xie, Zhiguo Fang, Yangmei Wang, Jiasui Zhan   +5 more
wiley   +1 more source

Leaf Structure and Hormonal Balance Modulate Host‐Specificity and Pathogenicity of Botrytis cinerea

Plant, Cell &Environment, EarlyView.
ABSTRACT Botrytis cinerea, a highly successful necrotrophic fungal plant pathogen, demonstrates a remarkably broad host range, yet the precise factors governing its host specificity and its ability to coexist non‐pathogenically with plants remain unclear. This study systematically assessed host preference in a series of B. cinerea agricultural isolates,
Gautam Anand, Chen Benoni, Meirav Leibman‐Markus, Rupali Gupta, Iftah Marash, Loida Tejada, Tali Dolgov, Dalia Rav‐David, Ondřej Plíhal, Ondřej Novák, Maya Kleiman, Yigal Elad, Maya Bar   +12 more
wiley   +1 more source

Epistasis buffers the fitness effects of rifampicin- resistance mutations in Pseudomonas aeruginosa.

, 2011
Epistatic interactions between resistance mutations in antibiotic-free environments potentially play a crucial role in the spread of resistance in pathogen populations by determining the fitness cost associated with resistance.
Alex R. Hall, R. Craig MacLean
core   +1 more source

BvCaM7 Participates in Sugar Beet (Beta vulgaris L.) Resistance to CLS (Cercospora Leaf Spot) by Activating BvPAL via BvMYB108 and Is Accompanied by Calcium Dynamics

Plant, Cell &Environment, EarlyView.
ABSTRACT CLS (Cercospora leaf spot) is a major constraint in sugar beet (Beta vulgaris L.) cultivation, yet the functions of CaM/CML family members in CLS resistance are unclear. This study identified the CaM/CML family in sugar beet and focused on BvCaM7, which was significantly upregulated under CLS. Calcium measurements revealed differential calcium
Meilin He, Hongyong Lou, Guangzhou Ding, Chunlei Zhao   +3 more
wiley   +1 more source

Susceptibility Profiles of Mycobacterium ulcerans Isolates to Streptomycin and Rifampicin in Two Districts of the Eastern Region of Ghana

International Journal of Microbiology, 2016
Background. Drug resistance is a major challenge in antibiotic chemotherapy. Assessing resistance profiles of pathogens constitutes an essential surveillance tool in the epidemiology and control of infectious diseases, including Buruli ulcer (BU) disease.
Enid Owusu, Mercy Jemima Newman, Nana Konama Kotey, Amos Akumwena, Elizabeth Bannerman   +4 more
doaj   +1 more source