Results 111 to 120 of about 3,000 (187)

Enriched whole genome sequencing identified compensatory mutations in the RNA polymerase gene of rifampicin-resistant Mycobacterium leprae strains

Infection and Drug Resistance, 2018
Mallika Lavania,1 Itu Singh,1 Ravindra P Turankar,1 Anuj Kumar Gupta,2 Madhvi Ahuja,1 Vinay Pathak,1 Utpal Sengupta1 1Stanley Browne Laboratory, The Leprosy Mission Trust India, TLM Community Hospital Nand Nagari, 2Agilent Technologies India Pvt Ltd ...
Lavania M, Singh I, Turankar RP, Gupta AK, Ahuja M, Pathak V, Sengupta U   +6 more
doaj  

The bacterial phosphotransferase system-mediated rifampicin phosphorylation: ancestral links to rifampicin-inactivating enzyme

Frontiers in Microbiology
IntroductionThe bacterial phosphotransferase system (PTS) transports and phosphorylates sugars. Some PTS proteins share structural motifs with rifampicin phosphotransferases (RPHs), which inactivate rifampicin by phosphorylation.
Šárka Bobková, Michaela Plechatá, Tomáš Kovaľ, Hana Šanderová, Simona Blažková, Rüveyda Akçin, Zdeněk Kameník, Jan Dohnálek, Libor Krásný, Jana Wiedermannová   +9 more
doaj   +1 more source

Bard1‐Mediated Regulation of Hnrnpa2b1 Ubiquitination and Protein Stability Contributes to Neuronal Ferroptosis and Cognitive Dysfunction Following Ischemic Stroke

CNS Neuroscience &Therapeutics, Volume 32, Issue 8, August 2026.
Bard1‐mediated ubiquitination of Hnrnpa2b1 in mice with PSCI destabilizes Sptbn2, which prevents the membrane translocation of Slc7a11 and reduces cystine uptake. This disruption of antioxidant defense triggers ferroptosis in hippocampal neurons, highlighting a novel molecular pathway linking post‐stroke cognitive impairment to ferroptosis of ...
Tuming Li, Tianyi Rong, Zuoting Shen, Zhenyu Wei, Deyan Chen, Ping Zhong, Li Cao   +6 more
wiley   +1 more source

Multifaceted Roles of Chloroquines in Gastrointestinal Disorders and Beyond

Comprehensive Physiology, Volume 16, Issue 4, August 2026.
Chloroquine (CQ) and hydroxychloroquine (HCQ) modulate lysosomal activity and autophagy, suppressing gastrointestinal inflammation and reshaping pathogenic microbiota. These mechanisms alleviate inflammatory bowel disease, inhibit associated tumor growth, and provide benefits in certain autoimmune and viral conditions.
Sihyun Jeong, Eunsoo Kim, Yong Sung Kim, Eunok Im   +3 more
wiley   +1 more source

Preserved Spermatogenesis and Hormonal Function in Men Receiving a Pretomanid Regimen (BPaMZ) for Pulmonary Drug‐Resistant Tuberculosis

Clinical Pharmacology &Therapeutics, Volume 120, Issue 2, Page 501-509, August 2026.
Pretomanid is a component of the World Health Organization‐recommended treatment regimen for drug‐resistant tuberculosis in patients aged ≥ 14 years. While preclinical rodent studies identified testicular toxicity as a potential clinical liability at elevated doses, no corresponding effects were observed in nonhuman primates nor clinical hormone ...
Pauline Howell, Antonio Lombardi, William Brumskine, Lali Mikiashvili, Kim Boekelheide, Joanna Moreira, Alda Holsta, Matthew Betteridge, Lindsay Thompson, Angela Crook, Paul Bruinenberg, Maria Beumont, Eugene Sun, Francesca Conradie   +13 more
wiley   +1 more source

HflX mediates rifampicin resistance in Brucella by downregulating the expression of RNA polymerase-associated genes

Frontiers in Microbiology
Brucella species (Brucella spp.) are facultative intracellular zoonotic pathogens responsible for brucellosis, a disease causing substantial global public health and economic burdens.
Hao Geng, Hao Geng, Hao Geng, Mengzhu Qi, Mengzhu Qi, Mengzhu Qi, Mengru Su, Mengru Su, Mengru Su, Feijie Zhi, Feijie Zhi, Feijie Zhi, Yuefeng Chu, Yuefeng Chu, Yuefeng Chu   +14 more
doaj   +1 more source

Prevalence, Antimicrobial Resistance Profile, and Multidrug Resistance of Methicillin‐Resistant Staphylococcus aureus (MDR‐MRSA) in Clinical Isolates From Indonesian Healthcare Facility: A Cross‐Sectional Study

Health Science Reports, Volume 9, Issue 8, August 2026.
ABSTRACT Background and Aims Methicillin‐resistant Staphylococcus aureus (MRSA) is a significant pathogen associated with hospital‐acquired infections, with its global prevalence, including in Indonesia, steadily increasing. However, comprehensive data on MRSA prevalence and antimicrobial susceptibility within Indonesian hospital settings remain ...
Muhammad Evy Prastiyanto, Afifah Khairunnisa, Shiv Kumar Sah   +2 more
wiley   +1 more source

Integrated HIV and TB Services for the Management of Coinfection in West Africa: A Scoping Review of Strategies, Outcomes, Barriers and Enablers

Health Science Reports, Volume 9, Issue 8, August 2026.
ABSTRACT Background and Aim There is a concern about treatment outcomes for human immunodeficiency virus and tuberculosis infections in West Africa. This has led to a focus on the development of strategies for integrated care; however, data on the barriers and enablers of these strategies are limited.
Chris Mensah Nartey, Adwoa Kumiwa Asare Afrane, Benjamin Tagoe, Awo Afi Kwapong, Seth Kwabena Amponsah   +4 more
wiley   +1 more source

Long‐Acting Injectable Antiretroviral Therapies for HIV Treatment and Prevention: Clinical Pharmacology, Recent Advances and Future Opportunities

The Journal of Clinical Pharmacology, Volume 66, Issue 8, August 2026.
Abstract Long‐acting (LA) antiretroviral (ARV) medications represent a significant advancement in the HIV treatment and prevention field. LA ARVs help reduce daily pill burden and thus optimize adherence, which has translated into sustained virologic suppression in persons with HIV, prevention of HIV transmission among those at risk, and improved ...
Alexandra Dunbar, Natella Rakhmanina, Justin Unternaher, Peter L. Anderson, Kristina M. Brooks   +4 more
wiley   +1 more source

Household contact management for rifampicin-resistant tuberculosis

The Lancet Global Health, 2022
Anja Reuter, Ivy Apolisi, Johnny Daniels, Jennifer Furin, Helen Cox   +4 more
openaire   +3 more sources