Results 161 to 170 of about 97,638 (260)

Quality by Design‐Based Development of a Robust LC Method for Simultaneous Estimation of Process‐ and Degradation‐Related Impurities in Rifapentine Drug Product for the Treatment of Active and Latent Tuberculosis

Biomedical Chromatography, Volume 40, Issue 5, May 2026.
ABSTRACT A precise, robust, and stability‐indicating liquid chromatographic (LC) method coupled with a photodiode array (PDA) detector was developed and validated for the quantitative estimation of rifapentine, an essential therapeutic agent for both active and latent tuberculosis (TB).
Siva Prasad Korikana, Sreenivasa Rao Battula, Naresh Konduru, Aravind Kurnool, Divya Kumar Vemuri, Venkata Lakshamana Sagar Dantinapalli   +5 more
wiley   +1 more source

Destroyed Lung Syndrome—A Devastating and Neglected Consequence of Pulmonary Tuberculosis: Case Series From a Low‐Resource Setting in Ghana

Clinical Case Reports, Volume 14, Issue 4, April 2026.
Post‐pulmonary TB destroyed lung syndrome. ABSTRACT Tuberculous destroyed lung syndrome is a devastating and often neglected sequela of pulmonary tuberculosis. It has significant adverse effects on the quality of life of affected patients. This case series aims to raise awareness among clinicians and to emphasize the need for multifaceted preventive ...
Prosper Adjei, Kingsley Owusu Manu, Samuel Kyeremeh Adjei, Theophilus Nyamekye Yeboah, Bridget Maame Kweenuwa Ansah, Daniel Kwabena Asare, Fatimata Musah, Safura Alhassan   +7 more
wiley   +1 more source

Prosthetic joint infections [PDF]

, 2013
Objectives: To review the available literature on prosthetic joint infections and provide recommendations on management particularly the importance of identifying the causative organism and starting the most appropriate antimicrobial therapy.
Fsadni, Claudia, Fsadni, Peter
core  

Isoniazid-resistant, rifampicin-susceptible tuberculosis in India [PDF]

The Lancet Respiratory Medicine, 2018
Saurabh, Mittal, Pawan, Tiwari, Karan, Madan, Gopi Chand, Khilnani, Anant, Mohan, Vijay, Hadda   +5 more
openaire   +2 more sources

Risk of Acute Kidney Injury Associated With Nephrotoxic Burden in Hospitalized Patients: A Scoping Review

Clinical Pharmacology &Therapeutics, Volume 119, Issue 4, Page 891-904, April 2026.
Limited evidence exists synthesizing the risk of acute kidney injury (AKI) associated with the concomitant administration of multiple nephrotoxic drugs, and even less examining the concept of nephrotoxic burden. The objective of this scoping review was to (1) identify definitions of nephrotoxic burden; (2) methods used to quantify (use of calculations)
Wafa Alatawi, Jessica L. Wallace, Dhakrit Rungkitwattanakul, Britney A. Stottlemyer, Tiffany L. Tran, Melanie Manis Reida, Sandra L. Kane‐Gill   +6 more
wiley   +1 more source

Patterns of compensatory mutations in rpoA/B/C genes of multidrug resistant M. tuberculosis in Uganda.

PLoS ONE
Mutations in rpoB, a gene that encodes the bacterial RNA polymerase (RNAP) beta-subunit, can cause high-level resistance to rifampicin. Approximately 95% of rifampicin-resistant Mycobacterium tuberculosis clinical isolates harbour mutations in an 81-base
David Patrick Kateete, Shakira Namakula, Edgar Kigozi, Fred A Katabazi, George William Kasule, Kenneth Musisi, Edward Wampande, Deus Lukoye, Moses L Joloba   +8 more
doaj   +1 more source

The Potential of Bioinformatics in Revolutionizing Disease Diagnosis in Sub‐Saharan Africa: A Narrative Review

Health Science Reports, Volume 9, Issue 4, April 2026.
ABSTRACT Background and Aim Despite its role in healthcare delivery and accessibility, the potential of bioinformatics to transform disease diagnosis in SSA remains unknown. This narrative review aims to assess the current status of bioinformatics initiatives in SSA and evaluate the role of bioinformatics in transforming diagnosis of major diseases in ...
Wilfred Ofosu, Fleischer C. N. Kotey, Alex Odoom, Onyansaniba K. Ntim, Eric S. Donkor   +4 more
wiley   +1 more source

Hematological Profiles of Pulmonary Tuberculosis and Multi‐Drug‐Resistant Tuberculosis Patients at Debre Tabor Comprehensive Specialized Hospital, North‐Central Ethiopia: A Comparative Cross‐Sectional Study

Health Science Reports, Volume 9, Issue 4, April 2026.
ABSTRACT Background and Aims Tuberculosis is a major infectious disease that affects hematological profiles. However, limited data assess changes in hematological profiles among patients with pulmonary and multidrug‐resistant tuberculosis. Therefore, this study aimed to compare the hematological profiles of pulmonary and multidrug‐resistant ...
Ayenew Berhan, Bekele Sharew, Andargachew Almaw, Shewaneh Damtie, Biruk Legese, Mulat Erkihun, Ayenew Assefa, Birhanemaskal Malkamu, Getu Abeje, Birhanu Getie, Yenealem Solomon   +10 more
wiley   +1 more source

Nasal Carriage Rate of Biofilm Producing Methicillin Resistant Staphylococcus aureus and Its Associated Factors Among Health Care Workers at Hospital of Central Ethiopia

MicrobiologyOpen, Volume 15, Issue 2, April 2026.
ABSTRACT Not susceptible to methicillin Staphylococcus aureus (MRSA), is a potentially harmful bacteria that is resistant to the most important antimicrobial agents. Because MRSA is so resistant to many antibiotics, it can cause illnesses by forming biofilms.
Wubeshet Mathewos, Abera Kumalo, Takele Teklu, Tigistu Demisse, Muluneh Temesgen, Tariku Chinasho   +5 more
wiley   +1 more source

Unmasking rifampicin mono-resistance in tuberculosis patients in Cross River State, Nigeria

Discover Public Health
Background Rifampicin resistance has been assumed to be synonymous with multi-drug resistant tuberculosis (MDR-TB), but this approach could be exposing tuberculosis (TB) patients with rifampicin mono-resistance to unduly long and toxic treatment regimens.
Ernest Afu Ochang, Ubong Aniefiok Udoh, Akaninyene Asuquo Otu, Atana Uket Ewa, Chibuke Ibe, David A. J. Moore   +5 more
doaj   +1 more source