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BackgroundPakistan is among top five high burden countries for tuberculosis and drug resistant TB. Among rifampicin sensitive new pulmonary TB (PTB), prevalence of isoniazid resistance is 8.3% (95%CI: 7.0-10.7) and resistance to fluoroquinolone is higher
Sabira Tahseen +6 more
doaj +1 more source
Due to increasing rates of antimicrobial resistance (AMR) in Neisseria gonorrhoeae, alternative treatments should be considered. To assess rifampicin’s potential as a gonorrhea treatment, we used rpoB mutations to estimate rifampicin resistance in ...
Justine Schaeffer +11 more
doaj +1 more source
Background: A small proportion of false rifampicin resistant results have previously been reported using GeneXpert MTB/RIF version G4 on sputum samples; however, this has not been investigated for urine samples in HIV-associated tuberculosis (TB ...
Charlotte Schutz +6 more
doaj +1 more source
Genetic Transformation of Rifampicin Resistance in Lactobacillus acidophilus [PDF]
Lactobacillus acidophilus strain 100-33, originally isolated from swine faeces, was transformed to rifampicin resistance with DNA from spontaneous rifampicin-resistant mutants derived from it. Cells of the recipient strain were treated with lysozyme and mutanolysin, mixed with donor DNA and polyethylene glycol and grown on a regeneration medium ...
J H, Lin, D C, Savage
openaire +2 more sources
Diagnosis of rifampicin-resistant tuberculosis: Discordant results by diagnostic methods
The performance of the Xpert© MTB/RIF and MTBDRplus assays for the detection of rifampicin resistant Mycobacterium tuberculosis was compared to culture-based drug susceptibility testing in 30 specimens with rifampicin-resistant and rifampicin ...
Winnie Mwanza +8 more
doaj +1 more source
Rifampicin-resistant tuberculosis in Spain
Objective The aim of the study was to analyse the characteristics of rifampicin-resistant tuberculosis patients in Spain. Methods This was an ambispective observational study of a multicentre cohort of patients diagnosed between ...
José-María García-García +55 more
openaire +4 more sources
Chylothorax in a child with rifampicin-resistant tuberculosis
Chylothorax is rare in children. Only a few cases of tuberculosis (TB)-associated chylothorax have been reported. We present a child on standard four-drug TB treatment who presented with wheezing and a chylothorax. Bronchoscopy showed caseating lymph nodes, and rifampicin-resistant TB was identified from the bronchoalveolar lavage specimen.
McLaren, B +8 more
openaire +3 more sources
Daptomycin-reversible rifampicin resistance in vancomycin-resistant Enterococcus faecium [PDF]
In a previous study, we observed marked synergy between daptomycin and rifampicin against 73% of rifampicin-resistant, vancomycin-resistant Enterococcus faecium (VRE), with approximately 100-fold reductions in rifampicin MICs observed at one-eighth to one-fourth daptomycin MIC.
Kenneth H, Rand +2 more
openaire +2 more sources
rpoB mutations and their association with rifampicin resistance in clinical Staphylococcus epidermidis. [PDF]
Background: Staphylococcus epidermidis is a ubiquitous member of the healthy skin and mucous microbiota but is also an opportunistic pathogen responsible for various infections, often treated with antibiotics like rifampicin.
Edslev SM +9 more
europepmc +2 more sources
Virulence of Rifampicin-Resistant Mutants of Bacteria
1. ネズミチフス菌LT-2株および黄色ブドウ球菌209P株で,rifampicin (RFP)耐性の上昇は,ストレプトマイシン型を示した。2. ネズミチフス菌LT-2株におけるone-step RFP高度耐性菌の出現頻度は約10-8,黄色ブドウ球菌209P株では約10-7であつた。3. LT-2株に紫外線を照射するとRFP高度耐性菌の出現頻度は高くなるが,形質発現にかなりの時間を要するので,劣性変異と考えられる。4. LT-2株,209P株ともに,one-step RFP高度耐性菌は比較的高頻度にRFP耐性を失う。5.
WATANABE, Tsutomu +2 more
openaire +2 more sources

