Results 21 to 30 of about 2,415,366 (239)

Navigating a Path to Rifampicin Resistance in Tuberculosis. [PDF]

mBio, 2023
For model bacteria, genetic drug resistance usually arises from antibiotic-tolerant subpopulations, but whether this is true for the globally important pathogen Mycobacterium tuberculosis —the cause of tuberculosis—is not known. Here, we discuss a recent article by Sebastian et al. (J. Sebastian, A.
Agarwal S, Javid B.
europepmc   +6 more sources

Rifampicin resistance in tuberculosis outbreak, London, England [PDF]

, 2005
Mycobacterium tuberculosis isolates cultured from 6 patients associated with an isoniazid-resistant M. tuberculosis outbreak acquired rifampicin resistance. The rpoB gene sequence showed that resistance was associated with rare mutations in each isolate.
Shorten, R J, McHugh, TD, Claxton, A P, Claxton, AP, Mary Jo Knobloch, Gillespie, S H, Claire Jenkins, Stephen H. Gillespie, Shorten, RJ, McHugh, T D, Edward A. Belongia, Richard E. Besser, Timothy D. McHugh, Robert J. Shorten, Burney A. Kieke, Carolyn Janette, Gillespie, SH, Jeffrey P. Davis, Jenkins, C, Alleyna P. Claxton, Gillespie, S H ; id_orcid   +20 more
core   +3 more sources

Prevalence of rifampicin resistant pulmonary tuberculosis using geneXpert assay in Ethiopia, a systematic review and meta-analysis

Heliyon, 2023
Background: Drug-resistant tuberculosis continues to be a global public health threat. Ethiopia is one of the high-burden countries for tuberculosis and multi-drug resistant tuberculosis.
Maritu Demelash, Endalkachew Nibret, Tamirat Hailegebriel, Zebasil Minichil, Daniel Mekonnen   +4 more
doaj   +1 more source

GeneXpert MTB/RIF Ultra performance to detect uncommon rpoB mutations in Mycobacterium tuberculosis

BMC Research Notes, 2023
Objective To investigate the performance of GeneXpert MTB/RIF Ultra to accurately detect rifampicin resistance for less common rpoB mutations that potentially confer phenotypic resistance, we tested 28 such Mycobacterium tuberculosis cultures with Xpert ...
Leen Rigouts, Jelle Keysers, Reenaers Rabab, Kristina Fissette, Armand van Deun, Bouke Catherine de Jong   +5 more
doaj   +1 more source

Prevalence and drivers of false-positive rifampicin-resistant Xpert MTB/RIF results: a prospective observational study in Rwanda

The Lancet Microbe, 2020
Summary: Background: The Xpert MTB/RIF (Xpert) assay is used globally to rapidly diagnose tuberculosis and resistance to rifampicin. We investigated the frequency and predictors of false-positive findings of rifampicin resistance with Xpert. Methods: We
Jean Claude Semuto Ngabonziza, MSc, Tom Decroo, PhD, Patrick Migambi, MSc, Yves Mucyo Habimana, MD, Armand Van Deun, PhD, Conor J Meehan, PhD, Gabriela Torrea, PhD, Faridath Massou, PharmD, Willem Bram de Rijk, BS, Bertin Ushizimpumu, BS, Esdras Belamo Niyigena, BS, Emil Ivan, PhD, Jules Mugabo Semahore, MD, Jean Baptiste Mazarati, PhD, Corinne Simone Merle, PhD, Philip Supply, PhD, Dissou Affolabi, ProfPhD, Leen Rigouts, PhD, Bouke Catherine de Jong, ProfPhD   +18 more
doaj   +1 more source

Open wounds and rifampicin therapy are associated with rifampicin resistance among staphylococcal vascular graft/endograft infections [PDF]

, 2021
Background Optimal timing for rifampicin combination therapy in patients with staphylococcal vascular graft/endograft infection (S-VGEI) is unknown.
Zimmermann, Alexander, Zbinden, Reinhard, Leung, Yau Kei Stefan, Rancic, Zoran, Hasse, Barbara, Eberhard, Nadia, Zinkernagel, Annelies S; https://orcid.org/, Brugger, Silvio D; https://orcid.org/, Mestres, Carlos A, Ledergerber, Bruno, Alexia Anagnostopoulos, Dieter O Mayer, Zoran Rancic, Barbara Hasse (PI), Lars Husmann, Alexander Zimmermann, Reinhard Zbinden, Bruno Ledergerber, Silvio D Brugger, Barbara Hasse, Carlos A Mestres, null null, Annelies S Zinkernagel, Yau Kei Stefan Leung, Nadia Eberhard   +24 more
core   +1 more source

Selective Pressure by Rifampicin Modulates Mutation Rates and Evolutionary Trajectories of Mycobacterial Genomes

Microbiology Spectrum, 2023
Resistance to the frontline antibiotic rifampicin constitutes a challenge to the treatment and control of tuberculosis. Here, we analyzed the mutational landscape of Mycobacterium smegmatis during long-term evolution with increasing concentrations of ...
E. Cebrián-Sastre, A. Chiner-Oms, R. Torres-Pérez, I. Comas, J. C. Oliveros, J. Blázquez, A. Castañeda-García   +6 more
doaj   +1 more source

Increased rate of enteric bacteria as cause of periprosthetic joint infections in patients with liver cirrhosis

BMC Infectious Diseases, 2022
Introduction Periprosthetic joint infections (PJI) are a major complication in joint-arthroplasty. Rifampicin is often used as an additional agent to treat PJI, because it penetrates bacterial biofilms.
Uta S. Koepf, Sebastian Scheidt, Gunnar T. R. Hischebeth, Christian P. Strassburg, Dieter C. Wirtz, Thomas M. Randau, Philipp Lutz   +6 more
doaj   +1 more source

Resistance to rifampicin: a review [PDF]

The Journal of Antibiotics, 2014
Resistance to rifampicin (RIF) is a broad subject covering not just the mechanism of clinical resistance, nearly always due to a genetic change in the β subunit of bacterial RNA polymerase (RNAP), but also how studies of resistant polymerases have helped us understand the structure of the enzyme, the intricacies of the transcription process and its ...
openaire   +2 more sources

Low-cost rapid detection of rifampicin resistant tuberculosis using bacteriophage in Kampala, Uganda. [PDF]

, 2007
BACKGROUND: Resistance to anti-tuberculosis drugs is a serious public health problem. Multi-drug resistant tuberculosis (MDR-TB), defined as resistance to at least rifampicin and isoniazid, has been reported in all regions of the world.
Traore, Hamidou, Hamidou Traore, Jones-Lopez, Edward C, McNerney, Ruth, Eisenach Kathleen D, Joloba, Moses L, Jones-Lopez Edward C, Roy D Mugerwa, Smith, Peter G, Mugerwa, Roy D, Ogwang Sam, Smith Peter G, Moses L Joloba, Mallard, Kim, Kathleen D Eisenach, Jerrold J Ellner, Ellner, Jerrold J, Eisenach, Kathleen D, Ogwang, Sam, Mugerwa Roy D, Kayes, Susan, McNerney Ruth, Edward C Jones-Lopez, Kalpana Narayan, Ruth McNerney, Peter G Smith, Sam Ogwang, Susan Kayes, Joloba Moses L, Narayan, Kalpana, Francis Mumbowa, Narayan Kalpana, Ellner Jerrold J, Mumbowa, Francis, Kayes Susan, Kim Mallard, Traore Hamidou, Mumbowa Francis, Mallard Kim   +38 more
core   +1 more source