Results 11 to 20 of about 2,415,366 (239)

Pyrazinamide resistance in rifampicin discordant tuberculosis.

PLoS ONE, 2022
IntroductionMycobacterium tuberculosis strains with phenotypically susceptible rpoB mutations (rifampicin discordant) have emerged following implementation of rapid molecular drug resistance testing for tuberculosis. Whilst rifampicin resistance is known
Nomonde Ritta Mvelase, Ravesh Singh, Khine Swe Swe-Han, Koleka Patience Mlisana   +3 more
doaj   +4 more sources

Mutations outside the rifampicin resistance-determining region associated with rifampicin resistance in Mycobacterium tuberculosis [PDF]

Journal of Antimicrobial Chemotherapy, 2011
Ninety-six percent of rifampicin resistance in Mycobacterium tuberculosis was shown to be associated with mutations inside the 81 bp rifampicin resistance-determining region (RRDR) located in the centre of the rpoB gene. The detection of rifampicin resistance by targeting the RRDR failed to match with a resistant phenotype in 4% of all cases. Our study
Lau, TCK, Siu, GKH, Zhang, Y, Lau, RWT, Ho, PL, Yew, WW, Tsui, SKW, Cheng, VCC, Yuen, KY, Yam, WC   +9 more
openaire   +5 more sources

Inactivation of a New Potassium Channel Increases Rifampicin Resistance and Induces Collateral Sensitivity to Hydrophilic Antibiotics in Mycobacterium smegmatis

Antibiotics, 2022
Rifampicin is a critical first-line antibiotic for treating mycobacterial infections such as tuberculosis, one of the most serious infectious diseases worldwide.
Thi Thuy Do, Jerónimo Rodríguez-Beltran, Esmeralda Cebrián-Sastre, Alexandro Rodríguez-Rojas, Alfredo Castañeda-García, Jesús Blázquez   +5 more
doaj   +3 more sources

Cell membrane components of Brucella melitensis play important roles in the resistance of low-level rifampicin.

PLoS Neglected Tropical Diseases, 2020
Brucella spp. are facultative intracellular pathogens that can persistently colonize host cells and cause the zoonosis- brucellosis. The WHO recommended a treatment for brucellosis that involves a combination of doxycycline, rifampicin, or streptomycin ...
Xiaowen Yang, Tonglei Wu, Wenxiao Liu, Guozhong Tian, Hongyan Zhao, Dongri Piao, Hai Jiang, Qingmin Wu   +7 more
doaj   +2 more sources

Impact of rpoB gene mutations and Rifampicin-resistance levels on treatment outcomes in Rifampicin-resistant tuberculosis. [PDF]

BMC Infect Dis
Although many studies have examined the connection between mutations in the rpoB gene and drug resistance, the impact of common mutations on treatment outcomes for RR-TB is not yet fully understood.This study explores the relationship between rpoB gene mutations and drug-resistant phenotypes, assesses their role in predicting RR-TB prognosis, and ...
Jose Vadakunnel M, Nehru VJ, Brammacharry U, Ramachandra V, Palavesam S, Muthukumar A, Mani BR, R SS, Pradhabane G, Vn AD, Subramani S, Muthaiah M, Soundappan G.   +12 more
europepmc   +6 more sources

Rifampicin-induced transcriptome response in rifampicin-resistant Mycobacterium tuberculosis

Tuberculosis, 2013
Tuberculosis (TB) is still a major life-threatening infectious disease, within which especially the rise of multidrug resistant TB (MDR-TB) is currently worrying. This study focuses on mechanisms of development of rifampicin resistance, since rifampicin seems to play an important role in the development of MDR-TB.
de Knegt, G.J., Bruning, O., ten Kate, M.T., de Jong, M., van Belkum, A., Endtz, H.P., Breit, T.M., Bakker-Woudenberg, I.A.J.M., de Steenwinkel, J.E.M.   +8 more
openaire   +6 more sources

Resistance of Mycobacterium tuberculosis strains to Rifampicin: A systematic review and meta-analysis

Heliyon, 2019
Introduction: Antitubercular drug resistance strain is a horrifying barrier to effective TB treatment and prevention. The present study aimed to determine the prevalence and geographical distribution of rifampicin-resistance M. tuberculosis (MTB) strains.
Seifu Gizaw Feyisa, Ahmed Abdulahi Abdurahman, Worku Jimma, Eshetu Ejeta Chaka, Jalil Kardan-Yamchi, Hossein Kazemian   +5 more
doaj   +2 more sources

Prevalence and patterns of rifampicin and isoniazid resistance conferring mutations in Mycobacterium tuberculosis isolates from Uganda.

PLoS ONE, 2018
BackgroundAccurate diagnosis of tuberculosis, especially by using rapid molecular assays, can reduce transmission of drug resistant tuberculosis in communities.
Edgar Kigozi, George W Kasule, Kenneth Musisi, Deus Lukoye, Samuel Kyobe, Fred Ashaba Katabazi, Eddie M Wampande, Moses L Joloba, David Patrick Kateete   +8 more
doaj   +2 more sources

Serine/threonine protein kinase mediates rifampicin resistance in Brucella melitensis through interacting with ribosomal protein RpsD and affecting antioxidant capacity [PDF]

mSystems
Brucellosis, a zoonotic disease, has re-emerged in both humans and animals, causing significant economic losses globally. Recently, an increasing number of rifampicin-resistant Brucella strains have been isolated worldwide without detectable mutations in
Yaqin Yuan, Wenqing Ning, Junjie Chen, Jiquan Li, Tianqi Xue, Cuihong An, Lingling Mao, Guangzhi Zhang, Shizhong Zhou, Jiabo Ding, Xiaowen Yang, Jianqiang Ye   +11 more
doaj   +2 more sources

Rifampicin Resistance by Xpert MTB/RIF Assay in Pulmonary Tuberculosis- Is there a Need for Confirmation by Retesting? [PDF]

Journal of Clinical and Diagnostic Research, 2022
Introduction: Xpert Mycobacterium tuberculosis/Resistance to Rifampicin (MTB/RIF) assay detects MTB Complex (MTBC) and rifampicin resistance simultaneously. In high prevalence countries like India, detection of rifampicin resistance in sputum specimen of
Swapna Rajesh Kanade, Swati Vijay, Gita Nataraj   +2 more
doaj   +1 more source