Results 71 to 80 of about 2,415,366 (239)

The Effect of Dicloxacillin Administration on Pharmacokinetics of Narrow Therapeutic Window Drugs: Phenytoin and Warfarin

Clinical Pharmacology &Therapeutics, EarlyView.
Dicloxacillin is a penicillinase‐resistant beta‐lactam antibiotic and potent activator of the Pregnane X receptor (PXR), known to induce CYP2C9, CYP2C19, and CYP3A4 activity. Clinical data suggest it reduces anticoagulation in warfarin‐treated patients and increases the risk of thromboembolic events.
Chanan Shaul, Waseem Mujahed, Ibrahim Idries, Maor Wanounou, Meir Bialer, Yoseph Caraco   +5 more
wiley   +1 more source

Challenges for interpreting results of antimicrobial susceptibility testing for treating infections of foals with Rhodococcus equi

Equine Veterinary Journal, EarlyView.
Abstract Rhodococcus equi is a facultative intracellular pathogen and a major cause of pneumonia in foals worldwide. The standard treatment for affected foals is a combination of a macrolide with rifampicin. The widespread use of this combination has led to the emergence of multidrug‐resistant (MDR) strains of R. equi.
Marlane Geribone Seeger, Letícia Trevisan Gressler, Laura Huber, Sonsiray Alvarez‐Narvaez, Juliana Felipetto Cargnelutti, Angela Ilha Bordin, Sara D. Lawhon, Noah D. Cohen   +7 more
wiley   +1 more source

Prevalence, Risk Factors, and Treatment Outcomes of Isoniazid- and Rifampicin-Mono-Resistant Pulmonary Tuberculosis in Lima, Peru. [PDF]

PLoS ONE, 2016
BACKGROUND:Isoniazid and rifampicin are the two most efficacious first-line agents for tuberculosis (TB) treatment. We assessed the prevalence of isoniazid and rifampicin mono-resistance, associated risk factors, and the association of mono-resistance on
Leonela Villegas, Larissa Otero, Timothy R Sterling, Moises A Huaman, Patrick Van der Stuyft, Eduardo Gotuzzo, Carlos Seas   +6 more
doaj   +1 more source

Rifampicin-resistance, rpoB polymorphism and RNA polymerase genetic engineering [PDF]

, 2015
Following its introduction in 1967, rifampicin has become a mainstay of therapy in the treatment of tuberculosis, leprosy and many other widespread diseases.
PALUMBO, CARLA, ALIFANO, Pietro, PASANISI, DANIELA, TALA', ADELFIA   +3 more
core   +1 more source

Predicting outcomes in equine peritonitis: Multivariable analysis of admission and post‐admission data from a UK hospital population

Equine Veterinary Journal, EarlyView.
Abstract Background Peritonitis is life‐threatening, and limited information exists regarding outcomes and predictors of survival. Objectives To report short‐ and long‐term outcomes in horses diagnosed with peritonitis and identify factors associated with survival. Study Design Retrospective observational. Methods Data were obtained for horses admitted
E. K. Kopec, H. Carslake, D. C. Archer, B. Morris, A. Wilson   +4 more
wiley   +1 more source

Annona squamosa: Phytochemical Fingerprinting, Health‐Improving Traits, and Functional Applications

Food Chemistry International, EarlyView.
Annona squamosa (custard apple) is a nutrient‐rich fruit containing diverse bioactive phytochemicals (e.g., acetogenins, flavonoids, and alkaloids) that contribute to multiple health benefits, including antioxidant, antihyperlipidemic, and antimicrobial activities, highlighting its potential as a functional food and medicinal resource.
Mohamed Fawzy Ramadan, Jumanah Reda Kurdi, Manar Yahya Alzahrani, Asmaa Ibrahim Alshaikhi, Jumanah Samir Hazzazi   +4 more
wiley   +1 more source

Multidrug-resistant tuberculosis/rifampicin-resistant tuberculosis: Principles of management

Lung India, 2018
Multidrug-resistant tuberculosis (MDR-TB)/rifampicin-resistant TB (RR-TB) is human-made problem and emerging due to poor management of TB and is a threat to control of TB. Early suspicion and diagnosis are important. Culture and drug susceptibility testing are gold standards, but newer molecular methods help in rapid diagnosis.
Rajendra Prasad, Nikhil Gupta, Amitabh Banka   +2 more
openaire   +3 more sources

Characterization of rifampicin-resistant Mycobacterium tuberculosis in Taiwan [PDF]

Journal of Medical Microbiology, 2003
Sixty-three rifampicin-resistant (Rifr) isolates of Mycobacterium tuberculosis from Kaohsiung, Taiwan, were analysed for mutations in the core region (69 bp, codons 511–533) of the rpoB gene. Some 84.1 % (53/63) of the resistant isolates showed mutations in this region, especially in codons 531 (41.5 %), 526 (18.9 %), 516 (15.1 %) and 533 (7.5 %). Five
Hsing-Yu, Hwang, Chung-Yu, Chang, Lin-Li, Chang, Shui-Feng, Chang, Ya-Hui, Chang, Yi-Jing, Chen   +5 more
openaire   +2 more sources

Multivariate Analysis of Characteristics Associated with Rifampicin Mono-resistance.

, 2016
Multivariate Analysis of Characteristics Associated with Rifampicin Mono-resistance.
Patrick Van der Stuyft (154687), Leonela Villegas (2590909), Larissa Otero (308500), Timothy R. Sterling (148936), Eduardo Gotuzzo (20728), Carlos Seas (308510), Moises A. Huaman (2590906)   +6 more
core   +1 more source

KLF15 as a Metabolic Gatekeeper Linking Drug Metabolism, Toxicity, and Precision Therapeutics

iNew Medicine, EarlyView.
KLF15‐mediated metabolic preconditioning links metabolic state to drug disposition, therapeutic efficacy, and adverse effects, extending classical xenobiotic sensing toward precision pharmacology. ABSTRACT Krüppel‐like factor 15 (KLF15) is emerging as a metabolic‐state‐sensitive regulator of hepatic endobiotic and xenobiotic metabolism.
Shilin Li, Xue Li, Zhengding Su, Shuxin Han   +3 more
wiley   +1 more source