Results 71 to 80 of about 3,000 (187)

Effect of the microbiome on pathogen susceptibility across four Drosophilidae species

Insect Science, EarlyView.
Four Drosophilidae species were used to investigate how variation in the host microbiome influences susceptibility to infection. Microbial composition and abundance differed among species and treatments. The effects of microbiome manipulation on host survival were both species‐ and pathogen‐specific.
Hongbo Sun, Ben Longdon, Ben Raymond
wiley   +1 more source

Molecular characterisation of rifampicin-resistant Mycobacterium tuberculosis strains from Malawi

African Journal of Laboratory Medicine, 2017
Background: Availability and access to the detection of resistance to anti-tuberculosis drug sremains a significant challenge in Malawi due to limited diagnostic services.
Tarsizio Chikaonda, Irene Ketseoglou, Nelson Nguluwe, Robert Krysiak, Isaac Thengolose, Felix Nyakwawa, Nora E. Rosenberg, Christopher Stanley, James Mpunga, Irving F. Hoffman, Maria A. Papathanasopoulos, Mina Hosseinipour, Lesley Scott, Wendy Stevens   +13 more
doaj   +1 more source

The Paediatric BCG Vaccine Century: From Historical Success to Future Innovations

Acta Paediatrica, EarlyView.
ABSTRACT Aim The tuberculosis (TB) vaccine, Bacille‐Calmette‐Guérin (BCG), protects infants against severe forms of primary TB. Yet, it does not protect against pulmonary reactivation TB in adults. Methods A literature review was conducted between 1st January and 28th February 2025 using PubMed, Google Scholar and reports of the World Health ...
Stefan H. E. Kaufmann
wiley   +1 more source

Prevalence and patterns of rifampicin and isoniazid resistance conferring mutations in Mycobacterium tuberculosis isolates from Uganda.

PLoS ONE, 2018
BackgroundAccurate diagnosis of tuberculosis, especially by using rapid molecular assays, can reduce transmission of drug resistant tuberculosis in communities.
Edgar Kigozi, George W Kasule, Kenneth Musisi, Deus Lukoye, Samuel Kyobe, Fred Ashaba Katabazi, Eddie M Wampande, Moses L Joloba, David Patrick Kateete   +8 more
doaj   +1 more source

Coupling of both a transactivation module and a double‐stranded DNA‐binding domain boosts Cas12i3 variant‐based cytosine and adenine editing in plants

Journal of Integrative Plant Biology, EarlyView.
Fusions of a transactivation module and a double‐stranded DNA‐binding domain produced effective Cas12i3 variant‐based cytosine and adenine base editors, with improved C‐to‐T and A‐to‐G base editing efficiency and expanded editing window. Generated herbicide‐resistant rice germplasm by using these base editors demonstrates their potential for precise ...
Chen Zhang, Jingying Li, Yucai Li, Lei Yan, Christina Seok Yien Yong, Shaoya Li, Yubing He, Lanqin Xia   +7 more
wiley   +1 more source

Next Generation Smart Implant Surfaces: Engineering Multifunctional Antimicrobial, Immunomodulatory and Regenerative Interfaces

Journal of Periodontal Research, EarlyView.
Natural‐inspired nano‐textured implant surfaces can be functionalised to modulate macrophage polarisation and local immune responses. This bioactive control promotes improved tissue integration and healing outcomes. ABSTRACT Dental implants rely on a stable and functional interface between the implant surface, surrounding tissues, and the oral ...
Roberto S. Pessoa, Lauren E. Steele, Mehvish Mumtaz, Denver P. Linklater, Neil M. O'Brien‐Simpson, Vladimir Baulin, Peter Kingshott, Roy Judge, Alastair J. Sloan, Elena P. Ivanova   +9 more
wiley   +1 more source

Prevalence and associated factors of rifampicin resistance pulmonary tuberculosis among HIV-positive patients in Bahir Dar, Northwest, Ethiopia

Scientific Reports
Tuberculosis (TB) remains a major public health problem and a leading cause of morbidity and mortality among people living with HIV, particularly in high-burden countries such as Ethiopia. TB control is severely compromised by rifampicin-resistant TB (RR-
Alemayehu Abate, Melkamnesh Azage, Abaineh Munshea   +2 more
doaj   +1 more source

Survey for secondary dapsone and rifampicin resistance in Cuba

Leprosy Review, 1993
A total of 1211 Cuban multibacillary leprosy patients treated for at least 5 years were clinically and bacteriologically examined. They were being treated according to a 2-phase monotherapy regimen with RMP first and DADDS afterwards. On skin-smear examination 50 patients were found positive, of which 9 showed a BI of 3+ or higher at any site.
A B, González, J L, Maestre, O, Hernández, Y, Columbié, N, Atrio, M, Martin, A M, Fernández, J, Rodríguez   +7 more
openaire   +2 more sources

The Synergy Between a Silver‐Ruthenium Antimicrobial and Aminoglycosides Is Based on Severe Macromolecular Damage

Molecular Microbiology, EarlyView.
AGXX enhances aminoglycoside activity against multidrug‐resistant pathogens such as uropathogenic Escherichia coli by increasing reactive oxygen species, causing protein aggregation and DNA damage. This effect is reduced by oxygen limitation or antioxidants. Polyphosphate protects cells from oxidative damage.
Emmanuel P. Oladokun, Gracious Y. Donkor, Julius K. Narh, Grady D. Jacobson, Cade Ward, Patrick O. Tawiah, Lisa K. Polzer, Kevin A. Edwards, Kyle A. Floyd, Jan‐Ulrik Dahl   +9 more
wiley   +1 more source

In vitro antimicrobial resistance properties of rifapentine and rifampicin are indistinguishable

Microbiology Spectrum
Tuberculosis (TB) is a major global health threat, with millions of new cases diagnosed annually. Rifampicin is a cornerstone drug in the current standard of care for TB treatment. Recently, rifapentine, an analog of rifampicin, has been considered as an
Valeria Barcelli, Bora Shin, Barry Boon Liang Choo, Sarah Leela Dorett, Pablo Bifani   +4 more
doaj   +1 more source